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Gene: HAX1 |
Gene summary for HAX1 |
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Gene information | Species | Human | Gene symbol | HAX1 | Gene ID | 10456 |
Gene name | HCLS1 associated protein X-1 | |
Gene Alias | HCLSBP1 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000422 | UniProtAcc | A0A0S2Z565 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10456 | HAX1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.86e-02 | 1.95e-01 | -0.1808 |
10456 | HAX1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.75e-04 | 3.95e-01 | 0.0216 |
10456 | HAX1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.41e-09 | 3.95e-01 | -0.0811 |
10456 | HAX1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.86e-03 | 1.52e-01 | -0.1088 |
10456 | HAX1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.07e-15 | 3.54e-01 | -0.1954 |
10456 | HAX1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.32e-04 | 4.87e-01 | -0.2196 |
10456 | HAX1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.97e-05 | 2.42e-01 | -0.1207 |
10456 | HAX1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.79e-04 | 3.13e-01 | -0.1526 |
10456 | HAX1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.31e-18 | 4.11e-01 | -0.1464 |
10456 | HAX1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.52e-05 | 2.25e-01 | -0.1001 |
10456 | HAX1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.72e-16 | 5.37e-01 | -0.059 |
10456 | HAX1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.08e-05 | 3.76e-01 | -0.1706 |
10456 | HAX1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.54e-03 | 3.95e-01 | -0.1462 |
10456 | HAX1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.68e-06 | 3.01e-01 | -0.0842 |
10456 | HAX1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.24e-02 | 2.85e-01 | -0.00410000000000005 |
10456 | HAX1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.05e-02 | 2.59e-01 | -0.0179 |
10456 | HAX1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.13e-16 | 4.31e-01 | 0.096 |
10456 | HAX1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.69e-03 | 3.43e-01 | 0.0446 |
10456 | HAX1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.55e-05 | 2.12e-01 | 0.0338 |
10456 | HAX1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.81e-11 | 3.15e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00331571 | Colorectum | SER | regulation of intracellular protein transport | 68/2897 | 229/18723 | 3.41e-08 | 2.30e-06 | 68 |
GO:00108211 | Colorectum | SER | regulation of mitochondrion organization | 48/2897 | 144/18723 | 7.51e-08 | 4.70e-06 | 48 |
GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
GO:19031461 | Colorectum | SER | regulation of autophagy of mitochondrion | 17/2897 | 33/18723 | 1.53e-06 | 6.86e-05 | 17 |
GO:00004221 | Colorectum | SER | autophagy of mitochondrion | 29/2897 | 81/18723 | 5.61e-06 | 2.01e-04 | 29 |
GO:00617261 | Colorectum | SER | mitochondrion disassembly | 29/2897 | 81/18723 | 5.61e-06 | 2.01e-04 | 29 |
GO:00726551 | Colorectum | SER | establishment of protein localization to mitochondrion | 38/2897 | 120/18723 | 6.60e-06 | 2.33e-04 | 38 |
GO:19030081 | Colorectum | SER | organelle disassembly | 36/2897 | 114/18723 | 1.22e-05 | 3.89e-04 | 36 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:00066261 | Colorectum | SER | protein targeting to mitochondrion | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
GO:00105061 | Colorectum | SER | regulation of autophagy | 74/2897 | 317/18723 | 1.39e-04 | 2.77e-03 | 74 |
GO:19037471 | Colorectum | SER | regulation of establishment of protein localization to mitochondrion | 18/2897 | 50/18723 | 3.00e-04 | 4.90e-03 | 18 |
GO:00315321 | Colorectum | SER | actin cytoskeleton reorganization | 30/2897 | 107/18723 | 6.38e-04 | 8.64e-03 | 30 |
GO:19035331 | Colorectum | SER | regulation of protein targeting | 24/2897 | 81/18723 | 9.20e-04 | 1.11e-02 | 24 |
GO:19032141 | Colorectum | SER | regulation of protein targeting to mitochondrion | 15/2897 | 44/18723 | 1.77e-03 | 1.82e-02 | 15 |
GO:00300991 | Colorectum | SER | myeloid cell differentiation | 80/2897 | 381/18723 | 2.28e-03 | 2.18e-02 | 80 |
GO:00480171 | Colorectum | SER | inositol lipid-mediated signaling | 42/2897 | 182/18723 | 4.36e-03 | 3.49e-02 | 42 |
GO:00480151 | Colorectum | SER | phosphatidylinositol-mediated signaling | 41/2897 | 178/18723 | 4.97e-03 | 3.86e-02 | 41 |
GO:00181051 | Colorectum | SER | peptidyl-serine phosphorylation | 66/2897 | 315/18723 | 5.47e-03 | 4.06e-02 | 66 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HAX1 | SNV | Missense_Mutation | novel | c.511N>A | p.Asp171Asn | p.D171N | O00165 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
HAX1 | SNV | Missense_Mutation | novel | c.775C>G | p.Pro259Ala | p.P259A | O00165 | protein_coding | deleterious(0.04) | possibly_damaging(0.561) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HAX1 | insertion | Nonsense_Mutation | novel | c.492_493insACTATGGAAATTCTAATTCCCTCCCAGTCCAGCTAGCATACAA | p.Pro165ThrfsTer12 | p.P165Tfs*12 | O00165 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
HAX1 | insertion | Frame_Shift_Ins | novel | c.173dupC | p.Glu59Ter | p.E59* | O00165 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HAX1 | SNV | Missense_Mutation | c.64N>T | p.Pro22Ser | p.P22S | O00165 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
HAX1 | SNV | Missense_Mutation | rs769438062 | c.196N>G | p.Ser66Gly | p.S66G | O00165 | protein_coding | tolerated(0.13) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
HAX1 | SNV | Missense_Mutation | c.827N>C | p.Phe276Ser | p.F276S | O00165 | protein_coding | deleterious(0.04) | benign(0.094) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HAX1 | SNV | Missense_Mutation | novel | c.259N>T | p.Asp87Tyr | p.D87Y | O00165 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HAX1 | SNV | Missense_Mutation | novel | c.560T>C | p.Leu187Pro | p.L187P | O00165 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3IA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HAX1 | SNV | Missense_Mutation | c.289N>A | p.Ala97Thr | p.A97T | O00165 | protein_coding | tolerated(0.28) | possibly_damaging(0.651) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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