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Gene: GPR68 |
Gene summary for GPR68 |
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Gene information | Species | Human | Gene symbol | GPR68 | Gene ID | 8111 |
Gene name | G protein-coupled receptor 68 | |
Gene Alias | AI2A6 | |
Cytomap | 14q32.11 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A1A5B2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8111 | GPR68 | P11T-E | Human | Esophagus | ESCC | 1.16e-09 | 4.29e-01 | 0.1426 |
8111 | GPR68 | P21T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.12e-01 | 0.1617 |
8111 | GPR68 | P32T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.57e-01 | 0.1666 |
8111 | GPR68 | P37T-E | Human | Esophagus | ESCC | 5.34e-06 | 2.26e-01 | 0.1371 |
8111 | GPR68 | P52T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.56e-01 | 0.1555 |
8111 | GPR68 | P62T-E | Human | Esophagus | ESCC | 8.23e-07 | 2.18e-01 | 0.1302 |
8111 | GPR68 | P89T-E | Human | Esophagus | ESCC | 9.70e-15 | 8.95e-01 | 0.1752 |
8111 | GPR68 | P91T-E | Human | Esophagus | ESCC | 3.88e-10 | 8.25e-01 | 0.1828 |
8111 | GPR68 | P130T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.33e-02 | 0.1676 |
8111 | GPR68 | C04 | Human | Oral cavity | OSCC | 2.16e-06 | 4.55e-01 | 0.2633 |
8111 | GPR68 | C21 | Human | Oral cavity | OSCC | 1.33e-20 | 6.33e-01 | 0.2678 |
8111 | GPR68 | C30 | Human | Oral cavity | OSCC | 1.18e-37 | 1.87e+00 | 0.3055 |
8111 | GPR68 | C43 | Human | Oral cavity | OSCC | 1.19e-07 | 2.51e-01 | 0.1704 |
8111 | GPR68 | C51 | Human | Oral cavity | OSCC | 7.11e-08 | 4.95e-01 | 0.2674 |
8111 | GPR68 | C06 | Human | Oral cavity | OSCC | 5.57e-12 | 1.39e+00 | 0.2699 |
8111 | GPR68 | LP15 | Human | Oral cavity | LP | 3.77e-04 | 9.30e-01 | 0.2174 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00987513 | Oral cavity | OSCC | bone cell development | 21/7305 | 34/18723 | 6.02e-03 | 2.28e-02 | 21 |
GO:19021075 | Oral cavity | OSCC | positive regulation of leukocyte differentiation | 77/7305 | 157/18723 | 6.55e-03 | 2.43e-02 | 77 |
GO:19037085 | Oral cavity | OSCC | positive regulation of hemopoiesis | 77/7305 | 157/18723 | 6.55e-03 | 2.43e-02 | 77 |
GO:00615153 | Oral cavity | OSCC | myeloid cell development | 38/7305 | 71/18723 | 9.12e-03 | 3.27e-02 | 38 |
GO:00303164 | Oral cavity | OSCC | osteoclast differentiation | 48/7305 | 94/18723 | 1.16e-02 | 3.92e-02 | 48 |
GO:00357744 | Oral cavity | OSCC | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 21/7305 | 36/18723 | 1.46e-02 | 4.76e-02 | 21 |
GO:1904951110 | Oral cavity | LP | positive regulation of establishment of protein localization | 132/4623 | 319/18723 | 3.06e-11 | 2.00e-09 | 132 |
GO:0051222110 | Oral cavity | LP | positive regulation of protein transport | 123/4623 | 303/18723 | 6.05e-10 | 2.96e-08 | 123 |
GO:007121417 | Oral cavity | LP | cellular response to abiotic stimulus | 121/4623 | 331/18723 | 8.45e-07 | 2.20e-05 | 121 |
GO:010400417 | Oral cavity | LP | cellular response to environmental stimulus | 121/4623 | 331/18723 | 8.45e-07 | 2.20e-05 | 121 |
GO:0030099110 | Oral cavity | LP | myeloid cell differentiation | 130/4623 | 381/18723 | 1.94e-05 | 3.27e-04 | 130 |
GO:000257315 | Oral cavity | LP | myeloid leukocyte differentiation | 71/4623 | 208/18723 | 1.35e-03 | 1.08e-02 | 71 |
GO:001072014 | Oral cavity | LP | positive regulation of cell development | 93/4623 | 298/18723 | 6.07e-03 | 3.60e-02 | 93 |
GO:000268315 | Oral cavity | LP | negative regulation of immune system process | 130/4623 | 434/18723 | 6.70e-03 | 3.90e-02 | 130 |
GO:190370619 | Oral cavity | LP | regulation of hemopoiesis | 111/4623 | 367/18723 | 8.48e-03 | 4.60e-02 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR68 | SNV | Missense_Mutation | novel | c.904N>A | p.Gly302Arg | p.G302R | Q15743 | protein_coding | tolerated(0.75) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPR68 | SNV | Missense_Mutation | novel | c.110N>T | p.Pro37Leu | p.P37L | Q15743 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DS-A7WH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPR68 | SNV | Missense_Mutation | novel | c.157N>T | p.Arg53Trp | p.R53W | Q15743 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
GPR68 | SNV | Missense_Mutation | c.191C>T | p.Thr64Met | p.T64M | Q15743 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AY-A54L-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GPR68 | SNV | Missense_Mutation | c.896G>A | p.Arg299His | p.R299H | Q15743 | protein_coding | deleterious(0.03) | probably_damaging(0.935) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GPR68 | SNV | Missense_Mutation | rs149975079 | c.547N>T | p.Arg183Cys | p.R183C | Q15743 | protein_coding | tolerated(0.14) | probably_damaging(0.947) | TCGA-CK-4950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folfox | SD |
GPR68 | SNV | Missense_Mutation | c.664C>T | p.Arg222Cys | p.R222C | Q15743 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPR68 | SNV | Missense_Mutation | c.1039N>A | p.Ala347Thr | p.A347T | Q15743 | protein_coding | tolerated_low_confidence(0.45) | benign(0) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GPR68 | SNV | Missense_Mutation | novel | c.415G>A | p.Val139Ile | p.V139I | Q15743 | protein_coding | tolerated(0.23) | benign(0.035) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR68 | SNV | Missense_Mutation | novel | c.238N>C | p.Tyr80His | p.Y80H | Q15743 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 404859017 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 178102508 | LORAZEPAM | |
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 404859018 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 404859019 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 374883820 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 385612200 |
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