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Gene: GDA |
Gene summary for GDA |
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Gene information | Species | Human | Gene symbol | GDA | Gene ID | 9615 |
Gene name | guanine deaminase | |
Gene Alias | CYPIN | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000255 | UniProtAcc | Q9Y2T3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9615 | GDA | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.29e-09 | 8.87e-01 | -0.1808 |
9615 | GDA | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.58e-03 | 2.69e-01 | -0.0811 |
9615 | GDA | HTA11_78_2000001011 | Human | Colorectum | AD | 6.31e-04 | 3.51e-01 | -0.1088 |
9615 | GDA | HTA11_347_2000001011 | Human | Colorectum | AD | 6.06e-04 | 4.83e-01 | -0.1954 |
9615 | GDA | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.70e-02 | 8.18e-01 | -0.2196 |
9615 | GDA | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.34e-03 | 4.75e-01 | -0.059 |
9615 | GDA | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.59e-05 | 1.43e+00 | 0.3487 |
9615 | GDA | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.13e-02 | 2.27e-01 | 0.281 |
9615 | GDA | CRC-1-8810 | Human | Colorectum | CRC | 7.56e-05 | 3.50e-01 | 0.6257 |
9615 | GDA | AEH-subject1 | Human | Endometrium | AEH | 3.00e-11 | 5.37e-01 | -0.3059 |
9615 | GDA | AEH-subject2 | Human | Endometrium | AEH | 9.63e-22 | 7.05e-01 | -0.2525 |
9615 | GDA | AEH-subject3 | Human | Endometrium | AEH | 4.70e-02 | 2.50e-01 | -0.2576 |
9615 | GDA | AEH-subject4 | Human | Endometrium | AEH | 6.96e-08 | 4.00e-01 | -0.2657 |
9615 | GDA | AEH-subject5 | Human | Endometrium | AEH | 4.57e-11 | 6.02e-01 | -0.2953 |
9615 | GDA | EEC-subject2 | Human | Endometrium | EEC | 3.15e-25 | 7.45e-01 | -0.2607 |
9615 | GDA | EEC-subject5 | Human | Endometrium | EEC | 5.10e-13 | 5.55e-01 | -0.249 |
9615 | GDA | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.17e-02 | 1.92e-01 | -0.1934 |
9615 | GDA | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.00e-11 | 4.51e-01 | -0.1917 |
9615 | GDA | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.10e-10 | 4.95e-01 | -0.1916 |
9615 | GDA | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.01e-13 | 4.31e-01 | -0.1269 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00467003 | Colorectum | MSI-H | heterocycle catabolic process | 50/1319 | 445/18723 | 7.21e-04 | 1.37e-02 | 50 |
GO:00091173 | Colorectum | MSI-H | nucleotide metabolic process | 53/1319 | 489/18723 | 1.16e-03 | 1.92e-02 | 53 |
GO:0006144 | Colorectum | MSI-H | purine nucleobase metabolic process | 6/1319 | 19/18723 | 1.48e-03 | 2.23e-02 | 6 |
GO:0009394 | Colorectum | MSI-H | 2'-deoxyribonucleotide metabolic process | 9/1319 | 40/18723 | 1.55e-03 | 2.33e-02 | 9 |
GO:00067533 | Colorectum | MSI-H | nucleoside phosphate metabolic process | 53/1319 | 497/18723 | 1.66e-03 | 2.45e-02 | 53 |
GO:00061633 | Colorectum | MSI-H | purine nucleotide metabolic process | 44/1319 | 396/18723 | 1.81e-03 | 2.61e-02 | 44 |
GO:00194393 | Colorectum | MSI-H | aromatic compound catabolic process | 50/1319 | 467/18723 | 2.04e-03 | 2.85e-02 | 50 |
GO:00091611 | Colorectum | MSI-H | ribonucleoside monophosphate metabolic process | 11/1319 | 58/18723 | 2.15e-03 | 2.92e-02 | 11 |
GO:0019692 | Colorectum | MSI-H | deoxyribose phosphate metabolic process | 9/1319 | 42/18723 | 2.22e-03 | 3.00e-02 | 9 |
GO:00725213 | Colorectum | MSI-H | purine-containing compound metabolic process | 45/1319 | 416/18723 | 2.73e-03 | 3.53e-02 | 45 |
GO:0009262 | Colorectum | MSI-H | deoxyribonucleotide metabolic process | 9/1319 | 44/18723 | 3.12e-03 | 3.89e-02 | 9 |
GO:19013613 | Colorectum | MSI-H | organic cyclic compound catabolic process | 51/1319 | 495/18723 | 4.07e-03 | 4.67e-02 | 51 |
GO:00091503 | Colorectum | MSI-H | purine ribonucleotide metabolic process | 40/1319 | 368/18723 | 4.19e-03 | 4.73e-02 | 40 |
GO:0009162 | Colorectum | MSI-H | deoxyribonucleoside monophosphate metabolic process | 6/1319 | 23/18723 | 4.31e-03 | 4.85e-02 | 6 |
GO:00091505 | Colorectum | CRC | purine ribonucleotide metabolic process | 74/2078 | 368/18723 | 2.58e-07 | 2.38e-05 | 74 |
GO:00061635 | Colorectum | CRC | purine nucleotide metabolic process | 78/2078 | 396/18723 | 2.98e-07 | 2.59e-05 | 78 |
GO:00092594 | Colorectum | CRC | ribonucleotide metabolic process | 75/2078 | 385/18723 | 7.83e-07 | 5.04e-05 | 75 |
GO:00725215 | Colorectum | CRC | purine-containing compound metabolic process | 79/2078 | 416/18723 | 1.15e-06 | 6.75e-05 | 79 |
GO:00196934 | Colorectum | CRC | ribose phosphate metabolic process | 75/2078 | 396/18723 | 2.36e-06 | 1.13e-04 | 75 |
GO:00346555 | Colorectum | CRC | nucleobase-containing compound catabolic process | 73/2078 | 407/18723 | 2.28e-05 | 6.57e-04 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GDA | SNV | Missense_Mutation | novel | c.311N>G | p.Thr104Ser | p.T104S | Q9Y2T3 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
GDA | SNV | Missense_Mutation | c.666N>C | p.Leu222Phe | p.L222F | Q9Y2T3 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GDA | SNV | Missense_Mutation | novel | c.448N>C | p.Ser150Pro | p.S150P | Q9Y2T3 | protein_coding | deleterious(0.02) | possibly_damaging(0.749) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GDA | SNV | Missense_Mutation | c.352N>A | p.Asp118Asn | p.D118N | Q9Y2T3 | protein_coding | tolerated(0.11) | benign(0.006) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
GDA | SNV | Missense_Mutation | rs748443792 | c.895N>A | p.Ala299Thr | p.A299T | Q9Y2T3 | protein_coding | tolerated(0.19) | possibly_damaging(0.446) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GDA | SNV | Missense_Mutation | c.574G>A | p.Glu192Lys | p.E192K | Q9Y2T3 | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GDA | SNV | Missense_Mutation | c.361N>A | p.Glu121Lys | p.E121K | Q9Y2T3 | protein_coding | tolerated(0.39) | benign(0.023) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GDA | SNV | Missense_Mutation | c.148N>G | p.Gln50Glu | p.Q50E | Q9Y2T3 | protein_coding | tolerated(0.37) | benign(0) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GDA | SNV | Missense_Mutation | c.738N>G | p.Asp246Glu | p.D246E | Q9Y2T3 | protein_coding | tolerated(0.69) | benign(0) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GDA | SNV | Missense_Mutation | c.74C>A | p.Pro25His | p.P25H | Q9Y2T3 | protein_coding | tolerated(0.22) | benign(0.029) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9615 | GDA | ENZYME | NSC-7861 | 7-METHYLXANTHINE | 20716488 | |
9615 | GDA | ENZYME | 8-AZAGUANINE | 8-AZAGUANINE | 7384171 | |
9615 | GDA | ENZYME | THIOGUANINE | THIOGUANINE | 7384171 |
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