![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FADS1 |
Gene summary for FADS1 |
![]() |
Gene information | Species | Human | Gene symbol | FADS1 | Gene ID | 3992 |
Gene name | fatty acid desaturase 1 | |
Gene Alias | D5D | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | A0A0A0MR51 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3992 | FADS1 | LZE2T | Human | Esophagus | ESCC | 6.80e-08 | 1.27e+00 | 0.082 |
3992 | FADS1 | LZE4T | Human | Esophagus | ESCC | 8.09e-09 | 3.91e-01 | 0.0811 |
3992 | FADS1 | LZE7T | Human | Esophagus | ESCC | 2.42e-06 | 5.85e-01 | 0.0667 |
3992 | FADS1 | LZE24T | Human | Esophagus | ESCC | 2.62e-10 | 3.29e-01 | 0.0596 |
3992 | FADS1 | P2T-E | Human | Esophagus | ESCC | 9.86e-34 | 5.50e-01 | 0.1177 |
3992 | FADS1 | P4T-E | Human | Esophagus | ESCC | 2.92e-49 | 1.13e+00 | 0.1323 |
3992 | FADS1 | P5T-E | Human | Esophagus | ESCC | 5.22e-43 | 9.18e-01 | 0.1327 |
3992 | FADS1 | P8T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.13e-01 | 0.0889 |
3992 | FADS1 | P9T-E | Human | Esophagus | ESCC | 1.53e-10 | 3.25e-01 | 0.1131 |
3992 | FADS1 | P10T-E | Human | Esophagus | ESCC | 2.65e-49 | 9.57e-01 | 0.116 |
3992 | FADS1 | P11T-E | Human | Esophagus | ESCC | 6.77e-15 | 6.99e-01 | 0.1426 |
3992 | FADS1 | P12T-E | Human | Esophagus | ESCC | 1.00e-24 | 4.91e-01 | 0.1122 |
3992 | FADS1 | P15T-E | Human | Esophagus | ESCC | 9.03e-08 | 1.96e-01 | 0.1149 |
3992 | FADS1 | P16T-E | Human | Esophagus | ESCC | 3.03e-18 | 4.68e-01 | 0.1153 |
3992 | FADS1 | P19T-E | Human | Esophagus | ESCC | 5.31e-14 | 1.09e+00 | 0.1662 |
3992 | FADS1 | P21T-E | Human | Esophagus | ESCC | 4.48e-05 | 1.95e-01 | 0.1617 |
3992 | FADS1 | P22T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.62e-01 | 0.1236 |
3992 | FADS1 | P23T-E | Human | Esophagus | ESCC | 4.63e-06 | 4.61e-01 | 0.108 |
3992 | FADS1 | P24T-E | Human | Esophagus | ESCC | 2.93e-15 | 3.85e-01 | 0.1287 |
3992 | FADS1 | P26T-E | Human | Esophagus | ESCC | 1.61e-32 | 6.44e-01 | 0.1276 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071496210 | Thyroid | ATC | cellular response to external stimulus | 165/6293 | 320/18723 | 2.01e-11 | 7.23e-10 | 165 |
GO:003166927 | Thyroid | ATC | cellular response to nutrient levels | 112/6293 | 215/18723 | 1.57e-08 | 3.20e-07 | 112 |
GO:003166827 | Thyroid | ATC | cellular response to extracellular stimulus | 125/6293 | 246/18723 | 1.65e-08 | 3.31e-07 | 125 |
GO:004259424 | Thyroid | ATC | response to starvation | 103/6293 | 197/18723 | 4.59e-08 | 8.31e-07 | 103 |
GO:000926724 | Thyroid | ATC | cellular response to starvation | 85/6293 | 156/18723 | 6.14e-08 | 1.09e-06 | 85 |
GO:0031667210 | Thyroid | ATC | response to nutrient levels | 212/6293 | 474/18723 | 2.37e-07 | 3.70e-06 | 212 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa012124 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa010402 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012125 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa010403 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012128 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa0121213 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FADS1 | SNV | Missense_Mutation | novel | c.1068G>A | p.Met356Ile | p.M356I | protein_coding | tolerated(0.33) | possibly_damaging(0.833) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |
FADS1 | SNV | Missense_Mutation | novel | c.1495N>A | p.Leu499Ile | p.L499I | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FADS1 | insertion | In_Frame_Ins | novel | c.1165_1166insCTGTCTGCCCCCATTTTGTCCCTGCAGCTC | p.Asn389delinsThrValCysProHisPheValProAlaAlaHis | p.N389delinsTVCPHFVPAAH | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
FADS1 | SNV | Missense_Mutation | c.1408N>C | p.Glu470Gln | p.E470Q | protein_coding | tolerated(0.53) | benign(0.034) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
FADS1 | SNV | Missense_Mutation | novel | c.200N>G | p.Thr67Ser | p.T67S | protein_coding | tolerated(0.76) | benign(0.019) | TCGA-CM-6166-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FADS1 | SNV | Missense_Mutation | novel | c.478N>T | p.Thr160Ser | p.T160S | protein_coding | tolerated(0.56) | benign(0.044) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FADS1 | insertion | Frame_Shift_Ins | novel | c.198_199insGTGAAGT | p.Thr67ValfsTer34 | p.T67Vfs*34 | protein_coding | TCGA-CM-6166-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
FADS1 | SNV | Missense_Mutation | rs375723539 | c.662C>T | p.Ala221Val | p.A221V | protein_coding | tolerated(0.16) | benign(0.112) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FADS1 | SNV | Missense_Mutation | novel | c.1492N>C | p.Tyr498His | p.Y498H | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
FADS1 | SNV | Missense_Mutation | c.885N>A | p.Phe295Leu | p.F295L | protein_coding | tolerated(0.41) | benign(0.036) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |