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Gene: EIF2S3 |
Gene summary for EIF2S3 |
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Gene information | Species | Human | Gene symbol | EIF2S3 | Gene ID | 1968 |
Gene name | eukaryotic translation initiation factor 2 subunit gamma | |
Gene Alias | EIF2 | |
Cytomap | Xp22.11 | |
Gene Type | protein-coding | GO ID | GO:0001731 | UniProtAcc | P41091 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1968 | EIF2S3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.44e-10 | 6.61e-01 | -0.0811 |
1968 | EIF2S3 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.87e-02 | 4.19e-01 | -0.1088 |
1968 | EIF2S3 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.47e-15 | 5.65e-01 | -0.1954 |
1968 | EIF2S3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.28e-06 | 4.67e-01 | -0.059 |
1968 | EIF2S3 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.30e-04 | 3.76e-01 | 0.096 |
1968 | EIF2S3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.74e-02 | 5.18e-01 | 0.0131 |
1968 | EIF2S3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.92e-20 | 7.72e-01 | 0.294 |
1968 | EIF2S3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.44e-03 | 8.94e-01 | 0.3487 |
1968 | EIF2S3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.35e-20 | 1.23e+00 | 0.281 |
1968 | EIF2S3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.57e-18 | 8.45e-01 | 0.3859 |
1968 | EIF2S3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.79e-02 | 4.67e-01 | 0.2585 |
1968 | EIF2S3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.31e-04 | 3.39e-01 | 0.3005 |
1968 | EIF2S3 | A015-C-203 | Human | Colorectum | FAP | 8.02e-04 | -1.06e-01 | -0.1294 |
1968 | EIF2S3 | A002-C-114 | Human | Colorectum | FAP | 2.42e-02 | -1.59e-01 | -0.1561 |
1968 | EIF2S3 | A015-C-104 | Human | Colorectum | FAP | 1.87e-04 | -1.04e-01 | -0.1899 |
1968 | EIF2S3 | A002-C-116 | Human | Colorectum | FAP | 2.37e-06 | -1.39e-01 | -0.0452 |
1968 | EIF2S3 | AEH-subject1 | Human | Endometrium | AEH | 2.63e-07 | -3.28e-01 | -0.3059 |
1968 | EIF2S3 | AEH-subject2 | Human | Endometrium | AEH | 1.53e-10 | -2.62e-01 | -0.2525 |
1968 | EIF2S3 | AEH-subject3 | Human | Endometrium | AEH | 7.34e-06 | -2.47e-01 | -0.2576 |
1968 | EIF2S3 | AEH-subject4 | Human | Endometrium | AEH | 2.31e-04 | -9.44e-02 | -0.2657 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:002261317 | Endometrium | EEC | ribonucleoprotein complex biogenesis | 108/2168 | 463/18723 | 4.60e-13 | 9.86e-11 | 108 |
GO:007182617 | Endometrium | EEC | ribonucleoprotein complex subunit organization | 65/2168 | 227/18723 | 1.91e-12 | 3.58e-10 | 65 |
GO:002261817 | Endometrium | EEC | ribonucleoprotein complex assembly | 63/2168 | 220/18723 | 4.16e-12 | 7.56e-10 | 63 |
GO:000641315 | Endometrium | EEC | translational initiation | 42/2168 | 118/18723 | 7.65e-12 | 1.24e-09 | 42 |
GO:000218315 | Endometrium | EEC | cytoplasmic translational initiation | 18/2168 | 34/18723 | 4.60e-09 | 3.14e-07 | 18 |
GO:000641717 | Endometrium | EEC | regulation of translation | 94/2168 | 468/18723 | 5.37e-08 | 2.88e-06 | 94 |
GO:004572716 | Endometrium | EEC | positive regulation of translation | 38/2168 | 136/18723 | 1.47e-07 | 6.89e-06 | 38 |
GO:003425016 | Endometrium | EEC | positive regulation of cellular amide metabolic process | 42/2168 | 162/18723 | 3.24e-07 | 1.32e-05 | 42 |
GO:000173112 | Endometrium | EEC | formation of translation preinitiation complex | 5/2168 | 11/18723 | 5.24e-03 | 3.26e-02 | 5 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
GO:0045727111 | Esophagus | ESCC | positive regulation of translation | 107/8552 | 136/18723 | 2.79e-15 | 1.68e-13 | 107 |
GO:0034250111 | Esophagus | ESCC | positive regulation of cellular amide metabolic process | 123/8552 | 162/18723 | 3.32e-15 | 1.93e-13 | 123 |
GO:0002183110 | Esophagus | ESCC | cytoplasmic translational initiation | 32/8552 | 34/18723 | 2.18e-09 | 4.94e-08 | 32 |
GO:00017319 | Esophagus | ESCC | formation of translation preinitiation complex | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF2S3 | SNV | Missense_Mutation | c.760C>A | p.Pro254Thr | p.P254T | P41091 | protein_coding | deleterious(0) | possibly_damaging(0.606) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | |
EIF2S3 | SNV | Missense_Mutation | c.757G>A | p.Glu253Lys | p.E253K | P41091 | protein_coding | tolerated(0.21) | benign(0) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
EIF2S3 | SNV | Missense_Mutation | c.1108N>A | p.Glu370Lys | p.E370K | P41091 | protein_coding | tolerated(0.09) | benign(0.019) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
EIF2S3 | SNV | Missense_Mutation | novel | c.521N>C | p.Leu174Pro | p.L174P | P41091 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF2S3 | SNV | Missense_Mutation | c.1189N>G | p.Lys397Glu | p.K397E | P41091 | protein_coding | deleterious(0.03) | possibly_damaging(0.772) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
EIF2S3 | SNV | Missense_Mutation | c.728T>C | p.Ile243Thr | p.I243T | P41091 | protein_coding | deleterious(0) | benign(0.182) | TCGA-AG-3885-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
EIF2S3 | SNV | Missense_Mutation | novel | c.1190A>G | p.Lys397Arg | p.K397R | P41091 | protein_coding | deleterious(0.05) | benign(0.151) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EIF2S3 | SNV | Missense_Mutation | c.1003N>A | p.Gly335Ser | p.G335S | P41091 | protein_coding | deleterious(0.05) | possibly_damaging(0.641) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EIF2S3 | insertion | Frame_Shift_Ins | novel | c.1321dupA | p.Ile441AsnfsTer4 | p.I441Nfs*4 | P41091 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EIF2S3 | SNV | Missense_Mutation | novel | c.311C>T | p.Ser104Phe | p.S104F | P41091 | protein_coding | deleterious(0.04) | possibly_damaging(0.786) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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