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Gene: EI24 |
Gene summary for EI24 |
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Gene information | Species | Human | Gene symbol | EI24 | Gene ID | 9538 |
Gene name | EI24 autophagy associated transmembrane protein | |
Gene Alias | EPG4 | |
Cytomap | 11q24.2 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | O14681 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9538 | EI24 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.29e-08 | 2.79e-01 | 0.0155 |
9538 | EI24 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.89e-10 | 4.93e-01 | -0.1808 |
9538 | EI24 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.00e-14 | 7.90e-01 | -0.0811 |
9538 | EI24 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.68e-17 | 8.11e-01 | -0.1088 |
9538 | EI24 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.25e-37 | 8.38e-01 | -0.1954 |
9538 | EI24 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.94e-07 | 8.00e-01 | -0.2602 |
9538 | EI24 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.07e-05 | 4.98e-01 | -0.1526 |
9538 | EI24 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.12e-09 | 3.52e-01 | -0.1464 |
9538 | EI24 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.12e-04 | 2.49e-01 | -0.1001 |
9538 | EI24 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.78e-20 | 7.37e-01 | -0.059 |
9538 | EI24 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.96e-03 | 5.50e-01 | -0.1706 |
9538 | EI24 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.60e-06 | 5.24e-01 | -0.2061 |
9538 | EI24 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.94e-02 | 4.10e-01 | -0.1462 |
9538 | EI24 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.96e-04 | 4.51e-01 | -0.0842 |
9538 | EI24 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.76e-12 | 6.79e-01 | -0.0179 |
9538 | EI24 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.70e-14 | 4.61e-01 | 0.096 |
9538 | EI24 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.36e-04 | 5.67e-01 | 0.0446 |
9538 | EI24 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.81e-02 | 3.99e-01 | 0.0528 |
9538 | EI24 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.28e-08 | 7.58e-01 | 0.0131 |
9538 | EI24 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.10e-06 | 5.77e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623623 | Thyroid | ATC | macroautophagy | 169/6293 | 291/18723 | 6.56e-18 | 7.69e-16 | 169 |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:000155826 | Thyroid | ATC | regulation of cell growth | 201/6293 | 414/18723 | 1.57e-10 | 4.76e-09 | 201 |
GO:004592622 | Thyroid | ATC | negative regulation of growth | 115/6293 | 249/18723 | 2.34e-05 | 2.06e-04 | 115 |
GO:003030813 | Thyroid | ATC | negative regulation of cell growth | 90/6293 | 188/18723 | 3.35e-05 | 2.78e-04 | 90 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411524 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa0411534 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa041156 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa0411511 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa041159 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411514 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411523 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
hsa0411533 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
hsa041158 | Prostate | BPH | p53 signaling pathway | 30/1718 | 74/8465 | 5.15e-05 | 3.40e-04 | 2.10e-04 | 30 |
hsa0411513 | Prostate | BPH | p53 signaling pathway | 30/1718 | 74/8465 | 5.15e-05 | 3.40e-04 | 2.10e-04 | 30 |
hsa0411522 | Prostate | Tumor | p53 signaling pathway | 29/1791 | 74/8465 | 2.99e-04 | 1.65e-03 | 1.02e-03 | 29 |
hsa0411532 | Prostate | Tumor | p53 signaling pathway | 29/1791 | 74/8465 | 2.99e-04 | 1.65e-03 | 1.02e-03 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EI24 | SNV | Missense_Mutation | c.299N>C | p.Val100Ala | p.V100A | O14681 | protein_coding | tolerated(0.09) | benign(0) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
EI24 | insertion | Frame_Shift_Ins | novel | c.1015_1016insTC | p.Gly339ValfsTer51 | p.G339Vfs*51 | O14681 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
EI24 | insertion | Nonsense_Mutation | novel | c.1016_1017insGCCCTGAGCAGCTCTACTTCTGCAGAGAAGTTCCCT | p.Gly339_His340insProTerAlaAlaLeuLeuLeuGlnArgSerSerLeu | p.G339_H340insP*AALLLQRSSL | O14681 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
EI24 | SNV | Missense_Mutation | c.296N>T | p.Ser99Leu | p.S99L | O14681 | protein_coding | tolerated(0.65) | benign(0.01) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EI24 | SNV | Missense_Mutation | c.360N>A | p.Phe120Leu | p.F120L | O14681 | protein_coding | tolerated(0.97) | probably_damaging(0.966) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EI24 | SNV | Missense_Mutation | rs534625909 | c.347C>T | p.Ser116Leu | p.S116L | O14681 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EI24 | SNV | Missense_Mutation | c.272G>A | p.Arg91Gln | p.R91Q | O14681 | protein_coding | tolerated(0.31) | benign(0.005) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EI24 | SNV | Missense_Mutation | c.394N>A | p.Leu132Ile | p.L132I | O14681 | protein_coding | tolerated(0.06) | probably_damaging(0.982) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
EI24 | SNV | Missense_Mutation | novel | c.241G>T | p.Val81Leu | p.V81L | O14681 | protein_coding | tolerated(0.07) | probably_damaging(0.987) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
EI24 | SNV | Missense_Mutation | novel | c.851G>A | p.Gly284Asp | p.G284D | O14681 | protein_coding | tolerated(0.29) | benign(0.035) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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