Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DTNBP1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DTNBP1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DTNBP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DTNBP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00990033 | Colorectum | CRC | vesicle-mediated transport in synapse | 45/2078 | 200/18723 | 2.67e-06 | 1.25e-04 | 45 |
GO:00516484 | Colorectum | CRC | vesicle localization | 41/2078 | 177/18723 | 3.39e-06 | 1.50e-04 | 41 |
GO:00163584 | Colorectum | CRC | dendrite development | 50/2078 | 243/18723 | 1.13e-05 | 3.67e-04 | 50 |
GO:00433935 | Colorectum | CRC | regulation of protein binding | 42/2078 | 196/18723 | 2.01e-05 | 5.90e-04 | 42 |
GO:00995181 | Colorectum | CRC | vesicle cytoskeletal trafficking | 21/2078 | 73/18723 | 2.87e-05 | 7.61e-04 | 21 |
GO:00160504 | Colorectum | CRC | vesicle organization | 57/2078 | 300/18723 | 3.36e-05 | 8.57e-04 | 57 |
GO:00995042 | Colorectum | CRC | synaptic vesicle cycle | 39/2078 | 181/18723 | 3.43e-05 | 8.71e-04 | 39 |
GO:00719004 | Colorectum | CRC | regulation of protein serine/threonine kinase activity | 65/2078 | 359/18723 | 4.67e-05 | 1.10e-03 | 65 |
GO:00488132 | Colorectum | CRC | dendrite morphogenesis | 32/2078 | 146/18723 | 1.19e-04 | 2.33e-03 | 32 |
GO:00508785 | Colorectum | CRC | regulation of body fluid levels | 65/2078 | 379/18723 | 2.38e-04 | 3.96e-03 | 65 |
GO:00513485 | Colorectum | CRC | negative regulation of transferase activity | 48/2078 | 268/18723 | 5.56e-04 | 7.70e-03 | 48 |
GO:00434051 | Colorectum | CRC | regulation of MAP kinase activity | 34/2078 | 177/18723 | 9.84e-04 | 1.18e-02 | 34 |
GO:00064694 | Colorectum | CRC | negative regulation of protein kinase activity | 39/2078 | 212/18723 | 1.04e-03 | 1.22e-02 | 39 |
GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
GO:0010970 | Colorectum | CRC | transport along microtubule | 30/2078 | 155/18723 | 1.67e-03 | 1.73e-02 | 30 |
GO:00230611 | Colorectum | CRC | signal release | 72/2078 | 463/18723 | 1.95e-03 | 1.96e-02 | 72 |
GO:00723842 | Colorectum | CRC | organelle transport along microtubule | 19/2078 | 85/18723 | 2.12e-03 | 2.09e-02 | 19 |
GO:19035323 | Colorectum | CRC | positive regulation of secretion by cell | 47/2078 | 282/18723 | 2.91e-03 | 2.64e-02 | 47 |
GO:00080881 | Colorectum | CRC | axo-dendritic transport | 17/2078 | 75/18723 | 3.04e-03 | 2.71e-02 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DTNBP1 | SNV | Missense_Mutation | novel | c.469A>G | p.Asn157Asp | p.N157D | Q96EV8 | protein_coding | tolerated(0.35) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DTNBP1 | deletion | Frame_Shift_Del | novel | c.597delN | p.Phe199LeufsTer27 | p.F199Lfs*27 | Q96EV8 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DTNBP1 | SNV | Missense_Mutation | rs75704383 | c.532N>A | p.Ala178Thr | p.A178T | Q96EV8 | protein_coding | tolerated(0.52) | benign(0.005) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DTNBP1 | SNV | Missense_Mutation | | c.955N>C | p.Val319Leu | p.V319L | Q96EV8 | protein_coding | deleterious(0) | benign(0.187) | TCGA-NH-A8F7-06 | Colorectum | NA | NA | NA | NA | NA | NA | NA |
DTNBP1 | SNV | Missense_Mutation | novel | c.400N>T | p.His134Tyr | p.H134Y | Q96EV8 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DTNBP1 | SNV | Missense_Mutation | novel | c.1046N>A | p.Ser349Asn | p.S349N | Q96EV8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.986) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DTNBP1 | SNV | Missense_Mutation | rs774300249 | c.325G>A | p.Ala109Thr | p.A109T | Q96EV8 | protein_coding | tolerated(0.35) | benign(0.215) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
DTNBP1 | SNV | Missense_Mutation | rs781381233 | c.887C>T | p.Pro296Leu | p.P296L | Q96EV8 | protein_coding | tolerated(0.18) | benign(0.183) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DTNBP1 | SNV | Missense_Mutation | novel | c.788N>G | p.Asn263Ser | p.N263S | Q96EV8 | protein_coding | tolerated(0.5) | benign(0.07) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DTNBP1 | SNV | Missense_Mutation | | c.295G>A | p.Glu99Lys | p.E99K | Q96EV8 | protein_coding | tolerated(0.05) | benign(0.053) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |