![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DEGS1 |
Gene summary for DEGS1 |
![]() |
Gene information | Species | Human | Gene symbol | DEGS1 | Gene ID | 8560 |
Gene name | delta 4-desaturase, sphingolipid 1 | |
Gene Alias | DEGS | |
Cytomap | 1q42.11 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A024R3P1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8560 | DEGS1 | LZE4T | Human | Esophagus | ESCC | 7.88e-21 | 9.54e-01 | 0.0811 |
8560 | DEGS1 | LZE7T | Human | Esophagus | ESCC | 1.08e-06 | 7.94e-01 | 0.0667 |
8560 | DEGS1 | LZE8T | Human | Esophagus | ESCC | 6.08e-06 | -9.21e-02 | 0.067 |
8560 | DEGS1 | LZE24T | Human | Esophagus | ESCC | 6.61e-04 | 3.33e-01 | 0.0596 |
8560 | DEGS1 | LZE6T | Human | Esophagus | ESCC | 2.38e-02 | 5.00e-01 | 0.0845 |
8560 | DEGS1 | P1T-E | Human | Esophagus | ESCC | 4.00e-03 | 5.50e-01 | 0.0875 |
8560 | DEGS1 | P2T-E | Human | Esophagus | ESCC | 1.04e-45 | 1.06e+00 | 0.1177 |
8560 | DEGS1 | P4T-E | Human | Esophagus | ESCC | 4.34e-36 | 1.17e+00 | 0.1323 |
8560 | DEGS1 | P5T-E | Human | Esophagus | ESCC | 2.35e-24 | 7.76e-01 | 0.1327 |
8560 | DEGS1 | P8T-E | Human | Esophagus | ESCC | 1.48e-21 | 2.65e-01 | 0.0889 |
8560 | DEGS1 | P9T-E | Human | Esophagus | ESCC | 1.09e-29 | 8.53e-01 | 0.1131 |
8560 | DEGS1 | P10T-E | Human | Esophagus | ESCC | 1.23e-58 | 1.29e+00 | 0.116 |
8560 | DEGS1 | P11T-E | Human | Esophagus | ESCC | 1.00e-28 | 1.58e+00 | 0.1426 |
8560 | DEGS1 | P12T-E | Human | Esophagus | ESCC | 1.42e-45 | 1.10e+00 | 0.1122 |
8560 | DEGS1 | P15T-E | Human | Esophagus | ESCC | 2.19e-33 | 1.07e+00 | 0.1149 |
8560 | DEGS1 | P16T-E | Human | Esophagus | ESCC | 3.91e-34 | 8.25e-01 | 0.1153 |
8560 | DEGS1 | P17T-E | Human | Esophagus | ESCC | 3.76e-07 | 3.56e-01 | 0.1278 |
8560 | DEGS1 | P19T-E | Human | Esophagus | ESCC | 9.12e-15 | 1.49e+00 | 0.1662 |
8560 | DEGS1 | P20T-E | Human | Esophagus | ESCC | 1.11e-57 | 1.50e+00 | 0.1124 |
8560 | DEGS1 | P21T-E | Human | Esophagus | ESCC | 1.03e-55 | 1.67e+00 | 0.1617 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425526 | Thyroid | ATC | myelination | 62/6293 | 134/18723 | 1.54e-03 | 7.84e-03 | 62 |
GO:00072726 | Thyroid | ATC | ensheathment of neurons | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
GO:00083666 | Thyroid | ATC | axon ensheathment | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0407116 | Esophagus | ESCC | Sphingolipid signaling pathway | 85/4205 | 121/8465 | 3.04e-06 | 1.73e-05 | 8.84e-06 | 85 |
hsa006003 | Esophagus | ESCC | Sphingolipid metabolism | 36/4205 | 53/8465 | 5.41e-03 | 1.36e-02 | 6.99e-03 | 36 |
hsa0407117 | Esophagus | ESCC | Sphingolipid signaling pathway | 85/4205 | 121/8465 | 3.04e-06 | 1.73e-05 | 8.84e-06 | 85 |
hsa0060012 | Esophagus | ESCC | Sphingolipid metabolism | 36/4205 | 53/8465 | 5.41e-03 | 1.36e-02 | 6.99e-03 | 36 |
hsa040718 | Liver | HCC | Sphingolipid signaling pathway | 72/4020 | 121/8465 | 5.01e-03 | 1.47e-02 | 8.18e-03 | 72 |
hsa00600 | Liver | HCC | Sphingolipid metabolism | 34/4020 | 53/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 34 |
hsa0407111 | Liver | HCC | Sphingolipid signaling pathway | 72/4020 | 121/8465 | 5.01e-03 | 1.47e-02 | 8.18e-03 | 72 |
hsa006001 | Liver | HCC | Sphingolipid metabolism | 34/4020 | 53/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 34 |
hsa0407114 | Oral cavity | OSCC | Sphingolipid signaling pathway | 82/3704 | 121/8465 | 6.97e-08 | 5.08e-07 | 2.58e-07 | 82 |
hsa006002 | Oral cavity | OSCC | Sphingolipid metabolism | 33/3704 | 53/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 33 |
hsa0407115 | Oral cavity | OSCC | Sphingolipid signaling pathway | 82/3704 | 121/8465 | 6.97e-08 | 5.08e-07 | 2.58e-07 | 82 |
hsa0060011 | Oral cavity | OSCC | Sphingolipid metabolism | 33/3704 | 53/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 33 |
hsa0407122 | Oral cavity | LP | Sphingolipid signaling pathway | 48/2418 | 121/8465 | 5.30e-03 | 2.15e-02 | 1.39e-02 | 48 |
hsa0407132 | Oral cavity | LP | Sphingolipid signaling pathway | 48/2418 | 121/8465 | 5.30e-03 | 2.15e-02 | 1.39e-02 | 48 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEGS1 | SNV | Missense_Mutation | c.147G>A | p.Met49Ile | p.M49I | O15121 | protein_coding | tolerated(0.41) | benign(0) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
DEGS1 | SNV | Missense_Mutation | c.266N>G | p.His89Arg | p.H89R | O15121 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DEGS1 | SNV | Missense_Mutation | novel | c.842C>T | p.Ala281Val | p.A281V | O15121 | protein_coding | deleterious(0) | possibly_damaging(0.579) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DEGS1 | SNV | Missense_Mutation | novel | c.820C>T | p.Pro274Ser | p.P274S | O15121 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
DEGS1 | SNV | Missense_Mutation | c.86N>G | p.Lys29Arg | p.K29R | O15121 | protein_coding | deleterious(0.03) | probably_damaging(0.967) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
DEGS1 | deletion | Frame_Shift_Del | novel | c.885delA | p.Val296TyrfsTer6 | p.V296Yfs*6 | O15121 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
DEGS1 | SNV | Missense_Mutation | novel | c.214G>T | p.Gly72Trp | p.G72W | O15121 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DEGS1 | SNV | Missense_Mutation | c.775C>T | p.His259Tyr | p.H259Y | O15121 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DEGS1 | insertion | Frame_Shift_Ins | rs771660755 | c.916_917insACAC | p.Ile306AsnfsTer35 | p.I306Nfs*35 | O15121 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
DEGS1 | insertion | In_Frame_Ins | novel | c.917_918insGAG | p.Ile306delinsMetArg | p.I306delinsMR | O15121 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8560 | DEGS1 | ENZYME | inhibitor | 252827536 | ||
8560 | DEGS1 | ENZYME | inhibitor | 178102663 |
Page: 1 |