Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CTSE_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CTSE_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CTSE_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CTSE_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CTSE_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00198844 | Stomach | WIM | antigen processing and presentation of exogenous antigen | 7/426 | 47/18723 | 8.61e-05 | 2.40e-03 | 7 |
GO:00024784 | Stomach | WIM | antigen processing and presentation of exogenous peptide antigen | 6/426 | 38/18723 | 1.99e-04 | 4.62e-03 | 6 |
GO:00198864 | Stomach | WIM | antigen processing and presentation of exogenous peptide antigen via MHC class II | 4/426 | 30/18723 | 4.53e-03 | 4.16e-02 | 4 |
GO:00480025 | Stomach | SIM | antigen processing and presentation of peptide antigen | 15/708 | 62/18723 | 7.10e-09 | 9.57e-07 | 15 |
GO:00198825 | Stomach | SIM | antigen processing and presentation | 18/708 | 106/18723 | 8.62e-08 | 7.97e-06 | 18 |
GO:00024785 | Stomach | SIM | antigen processing and presentation of exogenous peptide antigen | 11/708 | 38/18723 | 9.90e-08 | 8.64e-06 | 11 |
GO:00198845 | Stomach | SIM | antigen processing and presentation of exogenous antigen | 12/708 | 47/18723 | 1.21e-07 | 9.98e-06 | 12 |
GO:00024954 | Stomach | SIM | antigen processing and presentation of peptide antigen via MHC class II | 10/708 | 34/18723 | 3.23e-07 | 2.21e-05 | 10 |
GO:00025044 | Stomach | SIM | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 10/708 | 36/18723 | 5.84e-07 | 3.58e-05 | 10 |
GO:00198865 | Stomach | SIM | antigen processing and presentation of exogenous peptide antigen via MHC class II | 9/708 | 30/18723 | 1.05e-06 | 5.84e-05 | 9 |
GO:005160431 | Stomach | SIM | protein maturation | 21/708 | 294/18723 | 4.11e-03 | 3.70e-02 | 21 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSE | SNV | Missense_Mutation | rs782358758 | c.628G>C | p.Val210Leu | p.V210L | P14091 | protein_coding | tolerated(0.15) | probably_damaging(0.968) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
CTSE | SNV | Missense_Mutation | novel | c.813C>A | p.Phe271Leu | p.F271L | P14091 | protein_coding | tolerated(0.54) | possibly_damaging(0.859) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CTSE | insertion | Frame_Shift_Ins | novel | c.360_361insATTAATATATGTTATATAATATATAATATATT | p.Gln121IlefsTer49 | p.Q121Ifs*49 | P14091 | protein_coding | | | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD |
CTSE | insertion | Nonsense_Mutation | novel | c.814_815insCAGCCCTACCCCTAAGCCTCTATTAACTCCTTCCCAAA | p.Cys272SerfsTer9 | p.C272Sfs*9 | P14091 | protein_coding | | | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
CTSE | SNV | Missense_Mutation | | c.646T>C | p.Ser216Pro | p.S216P | P14091 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-EA-A3HT-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
CTSE | SNV | Missense_Mutation | novel | c.934N>C | p.Val312Leu | p.V312L | P14091 | protein_coding | tolerated(0.07) | benign(0.085) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CTSE | SNV | Missense_Mutation | | c.55G>A | p.Gly19Arg | p.G19R | P14091 | protein_coding | tolerated(0.48) | benign(0.031) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CTSE | SNV | Missense_Mutation | novel | c.451N>A | p.Asp151Asn | p.D151N | P14091 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CTSE | deletion | Frame_Shift_Del | novel | c.1021delN | p.Leu341TyrfsTer71 | p.L341Yfs*71 | P14091 | protein_coding | | | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CTSE | SNV | Missense_Mutation | novel | c.638N>T | p.Pro213Leu | p.P213L | P14091 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |