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Gene: CTHRC1 |
Gene summary for CTHRC1 |
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Gene information | Species | Human | Gene symbol | CTHRC1 | Gene ID | 115908 |
Gene name | collagen triple helix repeat containing 1 | |
Gene Alias | CTHRC1 | |
Cytomap | 8q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q96CG8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115908 | CTHRC1 | GSM4909281 | Human | Breast | IDC | 2.39e-56 | 9.28e-01 | 0.21 |
115908 | CTHRC1 | GSM4909282 | Human | Breast | IDC | 7.07e-41 | 7.22e-01 | -0.0288 |
115908 | CTHRC1 | GSM4909285 | Human | Breast | IDC | 5.61e-07 | 2.31e-01 | 0.21 |
115908 | CTHRC1 | GSM4909286 | Human | Breast | IDC | 5.87e-35 | 5.66e-01 | 0.1081 |
115908 | CTHRC1 | GSM4909287 | Human | Breast | IDC | 3.41e-16 | 4.42e-01 | 0.2057 |
115908 | CTHRC1 | GSM4909290 | Human | Breast | IDC | 3.64e-39 | 8.20e-01 | 0.2096 |
115908 | CTHRC1 | GSM4909302 | Human | Breast | IDC | 6.88e-11 | 3.79e-01 | 0.1545 |
115908 | CTHRC1 | GSM4909306 | Human | Breast | IDC | 1.97e-47 | 8.06e-01 | 0.1564 |
115908 | CTHRC1 | GSM4909319 | Human | Breast | IDC | 1.02e-16 | 7.08e-01 | 0.1563 |
115908 | CTHRC1 | Tumor | Human | Cervix | CC | 1.79e-63 | 9.69e-01 | 0.1241 |
115908 | CTHRC1 | sample3 | Human | Cervix | CC | 9.17e-47 | 7.69e-01 | 0.1387 |
115908 | CTHRC1 | T3 | Human | Cervix | CC | 4.94e-47 | 7.66e-01 | 0.1389 |
115908 | CTHRC1 | LZE5T | Human | Esophagus | ESCC | 7.29e-06 | 5.02e-01 | 0.0514 |
115908 | CTHRC1 | LZE24T | Human | Esophagus | ESCC | 1.08e-03 | 1.08e-01 | 0.0596 |
115908 | CTHRC1 | LZE21T | Human | Esophagus | ESCC | 1.41e-04 | 5.53e-01 | 0.0655 |
115908 | CTHRC1 | P2T-E | Human | Esophagus | ESCC | 1.30e-23 | 5.53e-01 | 0.1177 |
115908 | CTHRC1 | P4T-E | Human | Esophagus | ESCC | 2.57e-18 | 2.13e+00 | 0.1323 |
115908 | CTHRC1 | P5T-E | Human | Esophagus | ESCC | 2.59e-07 | 1.61e+00 | 0.1327 |
115908 | CTHRC1 | P8T-E | Human | Esophagus | ESCC | 4.54e-41 | 9.14e-01 | 0.0889 |
115908 | CTHRC1 | P9T-E | Human | Esophagus | ESCC | 3.70e-21 | 2.20e+00 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00901753 | Esophagus | ESCC | regulation of establishment of planar polarity | 37/8552 | 56/18723 | 1.65e-03 | 7.65e-03 | 37 |
GO:00301788 | Esophagus | ESCC | negative regulation of Wnt signaling pathway | 97/8552 | 170/18723 | 1.81e-03 | 8.31e-03 | 97 |
GO:00456675 | Esophagus | ESCC | regulation of osteoblast differentiation | 77/8552 | 132/18723 | 2.28e-03 | 1.00e-02 | 77 |
GO:00017361 | Esophagus | ESCC | establishment of planar polarity | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:00071641 | Esophagus | ESCC | establishment of tissue polarity | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:00355671 | Esophagus | ESCC | non-canonical Wnt signaling pathway | 45/8552 | 72/18723 | 2.97e-03 | 1.24e-02 | 45 |
GO:00456695 | Esophagus | ESCC | positive regulation of osteoblast differentiation | 43/8552 | 69/18723 | 3.93e-03 | 1.59e-02 | 43 |
GO:00900905 | Esophagus | ESCC | negative regulation of canonical Wnt signaling pathway | 78/8552 | 137/18723 | 5.17e-03 | 1.95e-02 | 78 |
GO:0042249 | Esophagus | ESCC | establishment of planar polarity of embryonic epithelium | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
GO:20000274 | Esophagus | ESCC | regulation of animal organ morphogenesis | 71/8552 | 125/18723 | 7.97e-03 | 2.84e-02 | 71 |
GO:0090177 | Esophagus | ESCC | establishment of planar polarity involved in neural tube closure | 10/8552 | 12/18723 | 8.94e-03 | 3.12e-02 | 10 |
GO:005109812 | Liver | Cirrhotic | regulation of binding | 148/4634 | 363/18723 | 9.14e-12 | 5.97e-10 | 148 |
GO:004339312 | Liver | Cirrhotic | regulation of protein binding | 83/4634 | 196/18723 | 4.44e-08 | 1.42e-06 | 83 |
GO:005109912 | Liver | Cirrhotic | positive regulation of binding | 74/4634 | 173/18723 | 1.44e-07 | 3.87e-06 | 74 |
GO:003209211 | Liver | Cirrhotic | positive regulation of protein binding | 41/4634 | 85/18723 | 2.28e-06 | 4.19e-05 | 41 |
GO:001605511 | Liver | Cirrhotic | Wnt signaling pathway | 150/4634 | 444/18723 | 9.75e-06 | 1.42e-04 | 150 |
GO:019873811 | Liver | Cirrhotic | cell-cell signaling by wnt | 150/4634 | 446/18723 | 1.28e-05 | 1.80e-04 | 150 |
GO:003011111 | Liver | Cirrhotic | regulation of Wnt signaling pathway | 112/4634 | 328/18723 | 7.57e-05 | 8.40e-04 | 112 |
GO:00016495 | Liver | Cirrhotic | osteoblast differentiation | 80/4634 | 229/18723 | 3.39e-04 | 2.91e-03 | 80 |
GO:006082811 | Liver | Cirrhotic | regulation of canonical Wnt signaling pathway | 86/4634 | 253/18723 | 5.70e-04 | 4.46e-03 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTHRC1 | insertion | Nonsense_Mutation | novel | c.472_473insCAGTAAATATTTTTTGAATGCAAAAACAAGAGGAAATATATAAATTG | p.Tyr158SerfsTer6 | p.Y158Sfs*6 | Q96CG8 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CTHRC1 | insertion | Nonsense_Mutation | novel | c.492_493insTAAAAACAGGGA | p.Ala164_Glu165insTer | p.A164_E165ins* | Q96CG8 | protein_coding | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CTHRC1 | SNV | Missense_Mutation | novel | c.584N>T | p.Ser195Phe | p.S195F | Q96CG8 | protein_coding | deleterious(0.01) | possibly_damaging(0.459) | TCGA-VS-A9UM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CTHRC1 | SNV | Missense_Mutation | rs767759004 | c.704N>A | p.Arg235His | p.R235H | Q96CG8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CTHRC1 | SNV | Missense_Mutation | rs374084026 | c.371C>T | p.Ala124Val | p.A124V | Q96CG8 | protein_coding | tolerated(0.61) | benign(0.122) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CTHRC1 | SNV | Missense_Mutation | rs141428810 | c.577C>T | p.Arg193Cys | p.R193C | Q96CG8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CTHRC1 | SNV | Missense_Mutation | rs767061518 | c.248N>A | p.Arg83Gln | p.R83Q | Q96CG8 | protein_coding | tolerated(0.05) | possibly_damaging(0.777) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CTHRC1 | SNV | Missense_Mutation | rs36115601 | c.578N>A | p.Arg193His | p.R193H | Q96CG8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CTHRC1 | SNV | Missense_Mutation | novel | c.449N>A | p.Arg150Lys | p.R150K | Q96CG8 | protein_coding | tolerated(1) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CTHRC1 | SNV | Missense_Mutation | novel | c.520N>T | p.Ala174Ser | p.A174S | Q96CG8 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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