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Gene: COX8A |
Gene summary for COX8A |
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Gene information | Species | Human | Gene symbol | COX8A | Gene ID | 1351 |
Gene name | cytochrome c oxidase subunit 8A | |
Gene Alias | COX | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P10176 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1351 | COX8A | GSM4909287 | Human | Breast | IDC | 1.98e-02 | 1.83e-01 | 0.2057 |
1351 | COX8A | GSM4909289 | Human | Breast | IDC | 1.21e-02 | 4.33e-01 | 0.1064 |
1351 | COX8A | GSM4909290 | Human | Breast | IDC | 6.24e-03 | 2.91e-01 | 0.2096 |
1351 | COX8A | GSM4909291 | Human | Breast | IDC | 1.15e-35 | 7.20e-01 | 0.1753 |
1351 | COX8A | GSM4909294 | Human | Breast | IDC | 1.13e-09 | 2.95e-02 | 0.2022 |
1351 | COX8A | GSM4909295 | Human | Breast | IDC | 1.08e-02 | 2.60e-01 | 0.0898 |
1351 | COX8A | GSM4909296 | Human | Breast | IDC | 3.35e-39 | 5.39e-01 | 0.1524 |
1351 | COX8A | GSM4909297 | Human | Breast | IDC | 1.75e-24 | -8.78e-02 | 0.1517 |
1351 | COX8A | GSM4909298 | Human | Breast | IDC | 4.64e-08 | 3.92e-01 | 0.1551 |
1351 | COX8A | GSM4909301 | Human | Breast | IDC | 2.09e-31 | 5.82e-01 | 0.1577 |
1351 | COX8A | GSM4909302 | Human | Breast | IDC | 3.36e-11 | 2.92e-01 | 0.1545 |
1351 | COX8A | GSM4909306 | Human | Breast | IDC | 3.48e-04 | 3.80e-01 | 0.1564 |
1351 | COX8A | GSM4909307 | Human | Breast | IDC | 4.65e-16 | 4.79e-01 | 0.1569 |
1351 | COX8A | GSM4909308 | Human | Breast | IDC | 2.34e-16 | 4.64e-01 | 0.158 |
1351 | COX8A | GSM4909309 | Human | Breast | IDC | 3.38e-08 | 1.31e-01 | 0.0483 |
1351 | COX8A | GSM4909311 | Human | Breast | IDC | 4.98e-51 | -5.42e-02 | 0.1534 |
1351 | COX8A | GSM4909312 | Human | Breast | IDC | 4.90e-16 | 1.49e-01 | 0.1552 |
1351 | COX8A | GSM4909313 | Human | Breast | IDC | 3.56e-03 | -2.62e-02 | 0.0391 |
1351 | COX8A | GSM4909315 | Human | Breast | IDC | 2.81e-10 | 3.26e-01 | 0.21 |
1351 | COX8A | GSM4909316 | Human | Breast | IDC | 5.47e-13 | 4.67e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004533314 | Cervix | HSIL_HPV | cellular respiration | 23/737 | 230/18723 | 4.13e-05 | 1.09e-03 | 23 |
GO:000612313 | Cervix | HSIL_HPV | mitochondrial electron transport, cytochrome c to oxygen | 6/737 | 21/18723 | 1.19e-04 | 2.42e-03 | 6 |
GO:002290014 | Cervix | HSIL_HPV | electron transport chain | 18/737 | 175/18723 | 1.93e-04 | 3.56e-03 | 18 |
GO:001598014 | Cervix | HSIL_HPV | energy derivation by oxidation of organic compounds | 24/737 | 318/18723 | 1.84e-03 | 1.96e-02 | 24 |
GO:000609114 | Cervix | HSIL_HPV | generation of precursor metabolites and energy | 32/737 | 490/18723 | 3.69e-03 | 3.27e-02 | 32 |
GO:004603425 | Cervix | N_HPV | ATP metabolic process | 40/534 | 277/18723 | 2.37e-17 | 5.40e-14 | 40 |
GO:000611924 | Cervix | N_HPV | oxidative phosphorylation | 24/534 | 141/18723 | 1.74e-12 | 2.64e-09 | 24 |
GO:000906024 | Cervix | N_HPV | aerobic respiration | 24/534 | 189/18723 | 9.57e-10 | 4.84e-07 | 24 |
GO:004277324 | Cervix | N_HPV | ATP synthesis coupled electron transport | 17/534 | 95/18723 | 1.39e-09 | 5.76e-07 | 17 |
GO:004277524 | Cervix | N_HPV | mitochondrial ATP synthesis coupled electron transport | 17/534 | 95/18723 | 1.39e-09 | 5.76e-07 | 17 |
GO:000609124 | Cervix | N_HPV | generation of precursor metabolites and energy | 40/534 | 490/18723 | 2.59e-09 | 7.88e-07 | 40 |
GO:001964624 | Cervix | N_HPV | aerobic electron transport chain | 16/534 | 87/18723 | 2.80e-09 | 7.98e-07 | 16 |
GO:004533324 | Cervix | N_HPV | cellular respiration | 25/534 | 230/18723 | 1.10e-08 | 1.85e-06 | 25 |
GO:002290424 | Cervix | N_HPV | respiratory electron transport chain | 17/534 | 114/18723 | 2.45e-08 | 3.18e-06 | 17 |
GO:002290024 | Cervix | N_HPV | electron transport chain | 21/534 | 175/18723 | 2.95e-08 | 3.63e-06 | 21 |
GO:001598024 | Cervix | N_HPV | energy derivation by oxidation of organic compounds | 25/534 | 318/18723 | 5.15e-06 | 1.89e-04 | 25 |
GO:190260023 | Cervix | N_HPV | proton transmembrane transport | 16/534 | 157/18723 | 1.11e-05 | 3.76e-04 | 16 |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0009060 | Colorectum | AD | aerobic respiration | 108/3918 | 189/18723 | 9.14e-28 | 1.43e-24 | 108 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0493216 | Breast | Precancer | Non-alcoholic fatty liver disease | 48/684 | 155/8465 | 6.16e-17 | 1.50e-15 | 1.15e-15 | 48 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0493217 | Breast | Precancer | Non-alcoholic fatty liver disease | 48/684 | 155/8465 | 6.16e-17 | 1.50e-15 | 1.15e-15 | 48 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0501623 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0019023 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0501023 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0501423 | Breast | IDC | Amyotrophic lateral sclerosis | 102/867 | 364/8465 | 1.29e-22 | 5.22e-21 | 3.91e-21 | 102 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COX8A | SNV | Missense_Mutation | c.36N>C | p.Leu12Phe | p.L12F | P10176 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
COX8A | SNV | Missense_Mutation | c.20T>C | p.Leu7Pro | p.L7P | P10176 | protein_coding | tolerated(0.34) | possibly_damaging(0.694) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COX8A | SNV | Missense_Mutation | rs550927126 | c.124N>A | p.Val42Ile | p.V42I | P10176 | protein_coding | tolerated(1) | benign(0.005) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
COX8A | SNV | Missense_Mutation | novel | c.202N>T | p.Pro68Ser | p.P68S | P10176 | protein_coding | deleterious(0.03) | benign(0.054) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
COX8A | SNV | Missense_Mutation | c.145N>A | p.Val49Met | p.V49M | P10176 | protein_coding | deleterious(0.01) | possibly_damaging(0.557) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
COX8A | SNV | Missense_Mutation | novel | c.169N>A | p.Trp57Arg | p.W57R | P10176 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-85-8049-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
COX8A | SNV | Missense_Mutation | novel | c.161C>T | p.Pro54Leu | p.P54L | P10176 | protein_coding | deleterious(0.04) | benign(0.291) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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