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Gene: CORO1B |
Gene summary for CORO1B |
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Gene information | Species | Human | Gene symbol | CORO1B | Gene ID | 57175 |
Gene name | coronin 1B | |
Gene Alias | CORONIN-2 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R5K1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57175 | CORO1B | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.20e-04 | 1.56e-01 | 0.0155 |
57175 | CORO1B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.81e-27 | 7.47e-01 | -0.1808 |
57175 | CORO1B | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.14e-03 | 3.47e-01 | 0.0216 |
57175 | CORO1B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.82e-08 | 3.50e-01 | -0.0811 |
57175 | CORO1B | HTA11_78_2000001011 | Human | Colorectum | AD | 5.30e-17 | 4.25e-01 | -0.1088 |
57175 | CORO1B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-25 | 5.73e-01 | -0.1954 |
57175 | CORO1B | HTA11_411_2000001011 | Human | Colorectum | SER | 9.97e-09 | 9.35e-01 | -0.2602 |
57175 | CORO1B | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.33e-08 | 6.64e-01 | -0.2196 |
57175 | CORO1B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.68e-08 | 3.28e-01 | -0.1207 |
57175 | CORO1B | HTA11_83_2000001011 | Human | Colorectum | SER | 1.29e-04 | 3.17e-01 | -0.1526 |
57175 | CORO1B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.48e-22 | 4.60e-01 | -0.1464 |
57175 | CORO1B | HTA11_866_2000001011 | Human | Colorectum | AD | 3.84e-03 | 1.79e-01 | -0.1001 |
57175 | CORO1B | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.53e-16 | 4.57e-01 | -0.059 |
57175 | CORO1B | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.44e-10 | 5.26e-01 | -0.2061 |
57175 | CORO1B | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.08e-03 | 2.94e-01 | -0.1462 |
57175 | CORO1B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.50e-06 | 3.60e-01 | -0.0842 |
57175 | CORO1B | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-03 | 1.75e-01 | 0.096 |
57175 | CORO1B | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.90e-03 | 4.85e-01 | 0.0451 |
57175 | CORO1B | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.22e-06 | 3.97e-01 | 0.0528 |
57175 | CORO1B | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.27e-08 | 3.95e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19029041 | Colorectum | SER | negative regulation of supramolecular fiber organization | 50/2897 | 167/18723 | 1.63e-06 | 7.23e-05 | 50 |
GO:00615721 | Colorectum | SER | actin filament bundle organization | 48/2897 | 161/18723 | 2.97e-06 | 1.19e-04 | 48 |
GO:00450101 | Colorectum | SER | actin nucleation | 22/2897 | 52/18723 | 3.25e-06 | 1.28e-04 | 22 |
GO:00514941 | Colorectum | SER | negative regulation of cytoskeleton organization | 48/2897 | 163/18723 | 4.34e-06 | 1.63e-04 | 48 |
GO:00510171 | Colorectum | SER | actin filament bundle assembly | 46/2897 | 157/18723 | 7.88e-06 | 2.69e-04 | 46 |
GO:00343141 | Colorectum | SER | Arp2/3 complex-mediated actin nucleation | 17/2897 | 39/18723 | 2.64e-05 | 7.21e-04 | 17 |
GO:00420601 | Colorectum | SER | wound healing | 97/2897 | 422/18723 | 2.69e-05 | 7.30e-04 | 97 |
GO:00016671 | Colorectum | SER | ameboidal-type cell migration | 105/2897 | 475/18723 | 6.97e-05 | 1.59e-03 | 105 |
GO:00901321 | Colorectum | SER | epithelium migration | 82/2897 | 360/18723 | 1.50e-04 | 2.93e-03 | 82 |
GO:00106311 | Colorectum | SER | epithelial cell migration | 81/2897 | 357/18723 | 1.87e-04 | 3.44e-03 | 81 |
GO:00901301 | Colorectum | SER | tissue migration | 82/2897 | 365/18723 | 2.40e-04 | 4.12e-03 | 82 |
GO:00511251 | Colorectum | SER | regulation of actin nucleation | 13/2897 | 30/18723 | 2.52e-04 | 4.23e-03 | 13 |
GO:19027431 | Colorectum | SER | regulation of lamellipodium organization | 19/2897 | 54/18723 | 2.90e-04 | 4.74e-03 | 19 |
GO:19027451 | Colorectum | SER | positive regulation of lamellipodium organization | 14/2897 | 37/18723 | 7.80e-04 | 9.87e-03 | 14 |
GO:00313461 | Colorectum | SER | positive regulation of cell projection organization | 75/2897 | 353/18723 | 2.22e-03 | 2.14e-02 | 75 |
GO:00435421 | Colorectum | SER | endothelial cell migration | 61/2897 | 279/18723 | 2.76e-03 | 2.47e-02 | 61 |
GO:00975811 | Colorectum | SER | lamellipodium organization | 24/2897 | 90/18723 | 4.33e-03 | 3.47e-02 | 24 |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00325352 | Colorectum | MSS | regulation of cellular component size | 127/3467 | 383/18723 | 3.44e-12 | 5.79e-10 | 127 |
GO:00329702 | Colorectum | MSS | regulation of actin filament-based process | 128/3467 | 397/18723 | 2.47e-11 | 3.49e-09 | 128 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CORO1B | SNV | Missense_Mutation | c.1385N>A | p.Ala462Asp | p.A462D | Q9BR76 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD | |
CORO1B | SNV | Missense_Mutation | rs757671047 | c.209N>A | p.Arg70His | p.R70H | Q9BR76 | protein_coding | deleterious(0.02) | possibly_damaging(0.684) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | c.619N>T | p.Arg207Trp | p.R207W | Q9BR76 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
CORO1B | SNV | Missense_Mutation | rs767771419 | c.1003G>A | p.Ala335Thr | p.A335T | Q9BR76 | protein_coding | tolerated(0.07) | benign(0.281) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | rs772528176 | c.1148N>A | p.Arg383Gln | p.R383Q | Q9BR76 | protein_coding | tolerated(0.39) | benign(0) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | rs769428845 | c.286N>A | p.Glu96Lys | p.E96K | Q9BR76 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CORO1B | SNV | Missense_Mutation | c.517N>G | p.Ser173Gly | p.S173G | Q9BR76 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-AH-6897-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CORO1B | insertion | In_Frame_Ins | novel | c.562_563insTCAGCTGGAACCACAATG | p.Val182_Asn187dup | p.V182_N187dup | Q9BR76 | protein_coding | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | ||
CORO1B | SNV | Missense_Mutation | novel | c.81N>T | p.Glu27Asp | p.E27D | Q9BR76 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | novel | c.236N>A | p.Cys79Tyr | p.C79Y | Q9BR76 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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