Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CIDEB_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CIDEB_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CIDEB_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CIDEB_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0052547110 | Oral cavity | LP | regulation of peptidase activity | 177/4623 | 461/18723 | 3.01e-11 | 2.00e-09 | 177 |
GO:005160416 | Oral cavity | LP | protein maturation | 122/4623 | 294/18723 | 1.37e-10 | 7.72e-09 | 122 |
GO:0052548110 | Oral cavity | LP | regulation of endopeptidase activity | 164/4623 | 432/18723 | 4.33e-10 | 2.20e-08 | 164 |
GO:0010952110 | Oral cavity | LP | positive regulation of peptidase activity | 88/4623 | 197/18723 | 6.52e-10 | 3.14e-08 | 88 |
GO:000863019 | Oral cavity | LP | intrinsic apoptotic signaling pathway in response to DNA damage | 51/4623 | 99/18723 | 8.01e-09 | 3.20e-07 | 51 |
GO:0010950110 | Oral cavity | LP | positive regulation of endopeptidase activity | 79/4623 | 179/18723 | 9.34e-09 | 3.62e-07 | 79 |
GO:001082118 | Oral cavity | LP | regulation of mitochondrion organization | 65/4623 | 144/18723 | 6.61e-08 | 2.24e-06 | 65 |
GO:000183617 | Oral cavity | LP | release of cytochrome c from mitochondria | 34/4623 | 59/18723 | 6.91e-08 | 2.33e-06 | 34 |
GO:000863719 | Oral cavity | LP | apoptotic mitochondrial changes | 51/4623 | 107/18723 | 2.07e-07 | 6.33e-06 | 51 |
GO:0031667110 | Oral cavity | LP | response to nutrient levels | 165/4623 | 474/18723 | 3.87e-07 | 1.12e-05 | 165 |
GO:200105619 | Oral cavity | LP | positive regulation of cysteine-type endopeptidase activity | 64/4623 | 148/18723 | 5.60e-07 | 1.51e-05 | 64 |
GO:009019913 | Oral cavity | LP | regulation of release of cytochrome c from mitochondria | 26/4623 | 48/18723 | 1.13e-05 | 2.04e-04 | 26 |
GO:001082214 | Oral cavity | LP | positive regulation of mitochondrion organization | 35/4623 | 74/18723 | 1.99e-05 | 3.34e-04 | 35 |
GO:001648513 | Oral cavity | LP | protein processing | 83/4623 | 225/18723 | 2.87e-05 | 4.52e-04 | 83 |
GO:009020011 | Oral cavity | LP | positive regulation of release of cytochrome c from mitochondria | 17/4623 | 28/18723 | 5.47e-05 | 7.57e-04 | 17 |
GO:00972021 | Oral cavity | LP | activation of cysteine-type endopeptidase activity | 11/4623 | 16/18723 | 2.52e-04 | 2.63e-03 | 11 |
GO:00316383 | Oral cavity | LP | zymogen activation | 26/4623 | 60/18723 | 1.19e-03 | 9.62e-03 | 26 |
GO:00525476 | Stomach | GC | regulation of peptidase activity | 67/1159 | 461/18723 | 5.35e-11 | 1.10e-08 | 67 |
GO:00525486 | Stomach | GC | regulation of endopeptidase activity | 63/1159 | 432/18723 | 1.76e-10 | 2.82e-08 | 63 |
GO:00971936 | Stomach | GC | intrinsic apoptotic signaling pathway | 43/1159 | 288/18723 | 7.09e-08 | 4.62e-06 | 43 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CIDEB | insertion | Frame_Shift_Ins | novel | c.233_234insATGGAGTGCTAACCCTGGTGCTAGA | p.Glu79TrpfsTer17 | p.E79Wfs*17 | Q9UHD4 | protein_coding | | | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD |
CIDEB | SNV | Missense_Mutation | novel | c.369N>C | p.Glu123Asp | p.E123D | Q9UHD4 | protein_coding | tolerated(0.34) | benign(0.005) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CIDEB | SNV | Missense_Mutation | | c.482N>G | p.Ser161Cys | p.S161C | Q9UHD4 | protein_coding | deleterious(0) | possibly_damaging(0.75) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CIDEB | SNV | Missense_Mutation | | c.208N>T | p.Asn70Tyr | p.N70Y | Q9UHD4 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CIDEB | SNV | Missense_Mutation | novel | c.639N>T | p.Lys213Asn | p.K213N | Q9UHD4 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
CIDEB | SNV | Missense_Mutation | | c.66N>C | p.Glu22Asp | p.E22D | Q9UHD4 | protein_coding | tolerated(0.44) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CIDEB | SNV | Missense_Mutation | rs146066890 | c.644N>A | p.Arg215His | p.R215H | Q9UHD4 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CIDEB | SNV | Missense_Mutation | rs368449983 | c.539G>A | p.Arg180His | p.R180H | Q9UHD4 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CIDEB | SNV | Missense_Mutation | novel | c.436N>T | p.Leu146Phe | p.L146F | Q9UHD4 | protein_coding | tolerated(0.89) | possibly_damaging(0.548) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CIDEB | SNV | Missense_Mutation | novel | c.400N>C | p.Phe134Leu | p.F134L | Q9UHD4 | protein_coding | tolerated(0.17) | benign(0) | TCGA-FV-A3R3-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |