![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CHPT1 |
Gene summary for CHPT1 |
![]() |
Gene information | Species | Human | Gene symbol | CHPT1 | Gene ID | 56994 |
Gene name | choline phosphotransferase 1 | |
Gene Alias | CPT | |
Cytomap | 12q23.2 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q8WUD6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56994 | CHPT1 | GSM4909282 | Human | Breast | IDC | 3.44e-11 | 4.08e-01 | -0.0288 |
56994 | CHPT1 | GSM4909285 | Human | Breast | IDC | 1.34e-04 | -2.58e-01 | 0.21 |
56994 | CHPT1 | GSM4909290 | Human | Breast | IDC | 1.40e-08 | -4.18e-01 | 0.2096 |
56994 | CHPT1 | GSM4909291 | Human | Breast | IDC | 1.05e-14 | -5.27e-01 | 0.1753 |
56994 | CHPT1 | GSM4909292 | Human | Breast | IDC | 8.14e-04 | -5.63e-01 | 0.1236 |
56994 | CHPT1 | GSM4909293 | Human | Breast | IDC | 8.71e-20 | 5.62e-01 | 0.1581 |
56994 | CHPT1 | GSM4909294 | Human | Breast | IDC | 1.43e-08 | -4.04e-01 | 0.2022 |
56994 | CHPT1 | GSM4909296 | Human | Breast | IDC | 1.24e-06 | -3.69e-01 | 0.1524 |
56994 | CHPT1 | GSM4909297 | Human | Breast | IDC | 1.60e-12 | -4.00e-01 | 0.1517 |
56994 | CHPT1 | GSM4909301 | Human | Breast | IDC | 6.15e-10 | -3.92e-01 | 0.1577 |
56994 | CHPT1 | GSM4909304 | Human | Breast | IDC | 1.53e-35 | 6.68e-01 | 0.1636 |
56994 | CHPT1 | GSM4909307 | Human | Breast | IDC | 2.37e-07 | -4.21e-01 | 0.1569 |
56994 | CHPT1 | GSM4909308 | Human | Breast | IDC | 2.98e-11 | -4.16e-01 | 0.158 |
56994 | CHPT1 | GSM4909309 | Human | Breast | IDC | 1.18e-03 | -2.70e-01 | 0.0483 |
56994 | CHPT1 | GSM4909311 | Human | Breast | IDC | 2.93e-24 | -4.29e-01 | 0.1534 |
56994 | CHPT1 | GSM4909312 | Human | Breast | IDC | 2.23e-07 | -3.50e-01 | 0.1552 |
56994 | CHPT1 | GSM4909315 | Human | Breast | IDC | 1.36e-20 | -5.34e-01 | 0.21 |
56994 | CHPT1 | GSM4909316 | Human | Breast | IDC | 2.71e-08 | -5.41e-01 | 0.21 |
56994 | CHPT1 | GSM4909317 | Human | Breast | IDC | 1.15e-11 | -4.36e-01 | 0.1355 |
56994 | CHPT1 | GSM4909319 | Human | Breast | IDC | 2.69e-29 | -4.56e-01 | 0.1563 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:001604912 | Lung | AIS | cell growth | 83/1849 | 482/18723 | 3.26e-07 | 2.79e-05 | 83 |
GO:000155812 | Lung | AIS | regulation of cell growth | 62/1849 | 414/18723 | 5.85e-04 | 9.03e-03 | 62 |
GO:00464701 | Lung | AIS | phosphatidylcholine metabolic process | 15/1849 | 74/18723 | 5.25e-03 | 4.49e-02 | 15 |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:000155816 | Oral cavity | OSCC | regulation of cell growth | 228/7305 | 414/18723 | 1.74e-11 | 6.09e-10 | 228 |
GO:00086543 | Oral cavity | OSCC | phospholipid biosynthetic process | 130/7305 | 253/18723 | 3.96e-05 | 3.46e-04 | 130 |
GO:00464743 | Oral cavity | OSCC | glycerophospholipid biosynthetic process | 102/7305 | 211/18723 | 3.50e-03 | 1.48e-02 | 102 |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
GO:001604918 | Oral cavity | LP | cell growth | 155/4623 | 482/18723 | 1.08e-04 | 1.31e-03 | 155 |
GO:000155817 | Oral cavity | LP | regulation of cell growth | 134/4623 | 414/18723 | 2.25e-04 | 2.41e-03 | 134 |
GO:0008611 | Oral cavity | LP | ether lipid biosynthetic process | 7/4623 | 11/18723 | 7.01e-03 | 3.96e-02 | 7 |
GO:0046504 | Oral cavity | LP | glycerol ether biosynthetic process | 7/4623 | 11/18723 | 7.01e-03 | 3.96e-02 | 7 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05231 | Colorectum | MSS | Choline metabolism in cancer | 34/1875 | 98/8465 | 2.90e-03 | 1.39e-02 | 8.50e-03 | 34 |
hsa052311 | Colorectum | MSS | Choline metabolism in cancer | 34/1875 | 98/8465 | 2.90e-03 | 1.39e-02 | 8.50e-03 | 34 |
hsa052319 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa0523114 | Esophagus | ESCC | Choline metabolism in cancer | 61/4205 | 98/8465 | 7.97e-03 | 1.92e-02 | 9.84e-03 | 61 |
hsa052316 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0523111 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0523121 | Lung | AIS | Choline metabolism in cancer | 23/961 | 98/8465 | 4.87e-04 | 4.39e-03 | 2.81e-03 | 23 |
hsa0523131 | Lung | AIS | Choline metabolism in cancer | 23/961 | 98/8465 | 4.87e-04 | 4.39e-03 | 2.81e-03 | 23 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHPT1 | SNV | Missense_Mutation | c.874N>C | p.Lys292Gln | p.K292Q | Q8WUD6 | protein_coding | tolerated(0.23) | benign(0.058) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
CHPT1 | SNV | Missense_Mutation | c.677N>G | p.Ile226Ser | p.I226S | Q8WUD6 | protein_coding | tolerated(0.13) | benign(0.017) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CHPT1 | SNV | Missense_Mutation | c.1000C>G | p.Leu334Val | p.L334V | Q8WUD6 | protein_coding | deleterious(0.01) | possibly_damaging(0.844) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CHPT1 | SNV | Missense_Mutation | c.356G>A | p.Arg119Lys | p.R119K | Q8WUD6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA3W-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CHPT1 | SNV | Missense_Mutation | novel | c.1040N>G | p.Glu347Gly | p.E347G | Q8WUD6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CHPT1 | SNV | Missense_Mutation | novel | c.1165N>A | p.Ala389Thr | p.A389T | Q8WUD6 | protein_coding | tolerated(0.13) | benign(0.035) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHPT1 | SNV | Missense_Mutation | novel | c.956N>G | p.Lys319Arg | p.K319R | Q8WUD6 | protein_coding | tolerated(0.15) | possibly_damaging(0.523) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHPT1 | insertion | Frame_Shift_Ins | rs781571380 | c.485dupT | p.Cys163LeufsTer31 | p.C163Lfs*31 | Q8WUD6 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CHPT1 | SNV | Missense_Mutation | novel | c.908G>A | p.Cys303Tyr | p.C303Y | Q8WUD6 | protein_coding | deleterious(0.02) | benign(0.065) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHPT1 | SNV | Missense_Mutation | novel | c.389N>A | p.Leu130His | p.L130H | Q8WUD6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
56994 | CHPT1 | NA | lamivudine | LAMIVUDINE |
Page: 1 |