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Gene: CEP19 |
Gene summary for CEP19 |
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Gene information | Species | Human | Gene symbol | CEP19 | Gene ID | 84984 |
Gene name | centrosomal protein 19 | |
Gene Alias | C3orf34 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q96LK0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84984 | CEP19 | LZE4T | Human | Esophagus | ESCC | 3.78e-08 | 2.57e-01 | 0.0811 |
84984 | CEP19 | LZE7T | Human | Esophagus | ESCC | 3.90e-02 | 1.73e-01 | 0.0667 |
84984 | CEP19 | LZE8T | Human | Esophagus | ESCC | 1.10e-02 | 1.29e-01 | 0.067 |
84984 | CEP19 | LZE21D1 | Human | Esophagus | HGIN | 2.75e-06 | 5.10e-01 | 0.0632 |
84984 | CEP19 | P1T-E | Human | Esophagus | ESCC | 1.64e-05 | 3.78e-01 | 0.0875 |
84984 | CEP19 | P2T-E | Human | Esophagus | ESCC | 9.74e-22 | 4.12e-01 | 0.1177 |
84984 | CEP19 | P4T-E | Human | Esophagus | ESCC | 1.17e-15 | 3.65e-01 | 0.1323 |
84984 | CEP19 | P5T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.96e-01 | 0.1327 |
84984 | CEP19 | P9T-E | Human | Esophagus | ESCC | 6.89e-11 | 3.04e-01 | 0.1131 |
84984 | CEP19 | P10T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.76e-01 | 0.116 |
84984 | CEP19 | P12T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.39e-01 | 0.1122 |
84984 | CEP19 | P15T-E | Human | Esophagus | ESCC | 1.32e-06 | 2.15e-01 | 0.1149 |
84984 | CEP19 | P16T-E | Human | Esophagus | ESCC | 4.16e-22 | 4.61e-01 | 0.1153 |
84984 | CEP19 | P20T-E | Human | Esophagus | ESCC | 4.38e-08 | 1.92e-01 | 0.1124 |
84984 | CEP19 | P21T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.08e-01 | 0.1617 |
84984 | CEP19 | P22T-E | Human | Esophagus | ESCC | 1.35e-23 | 4.47e-01 | 0.1236 |
84984 | CEP19 | P23T-E | Human | Esophagus | ESCC | 7.44e-14 | 4.27e-01 | 0.108 |
84984 | CEP19 | P24T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.05e-01 | 0.1287 |
84984 | CEP19 | P26T-E | Human | Esophagus | ESCC | 2.39e-24 | 4.50e-01 | 0.1276 |
84984 | CEP19 | P27T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.48e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19055086 | Esophagus | ESCC | protein localization to microtubule organizing center | 28/8552 | 35/18723 | 3.40e-05 | 2.78e-04 | 28 |
GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
GO:00715396 | Esophagus | ESCC | protein localization to centrosome | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:00467856 | Esophagus | ESCC | microtubule polymerization | 55/8552 | 83/18723 | 1.21e-04 | 8.31e-04 | 55 |
GO:00070205 | Esophagus | ESCC | microtubule nucleation | 27/8552 | 35/18723 | 1.48e-04 | 9.88e-04 | 27 |
GO:00512587 | Liver | NAFLD | protein polymerization | 49/1882 | 297/18723 | 3.54e-04 | 5.36e-03 | 49 |
GO:00715394 | Liver | NAFLD | protein localization to centrosome | 10/1882 | 33/18723 | 1.09e-03 | 1.27e-02 | 10 |
GO:19055084 | Liver | NAFLD | protein localization to microtubule organizing center | 10/1882 | 35/18723 | 1.79e-03 | 1.85e-02 | 10 |
GO:00726983 | Liver | NAFLD | protein localization to microtubule cytoskeleton | 12/1882 | 54/18723 | 6.44e-03 | 4.69e-02 | 12 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:005125822 | Liver | HCC | protein polymerization | 182/7958 | 297/18723 | 4.17e-11 | 1.58e-09 | 182 |
GO:014001411 | Liver | HCC | mitotic nuclear division | 174/7958 | 287/18723 | 3.74e-10 | 1.23e-08 | 174 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:005165021 | Liver | HCC | establishment of vesicle localization | 103/7958 | 161/18723 | 2.94e-08 | 6.69e-07 | 103 |
GO:000705211 | Liver | HCC | mitotic spindle organization | 80/7958 | 120/18723 | 7.43e-08 | 1.50e-06 | 80 |
GO:190285011 | Liver | HCC | microtubule cytoskeleton organization involved in mitosis | 93/7958 | 147/18723 | 2.91e-07 | 5.09e-06 | 93 |
GO:00481991 | Liver | HCC | vesicle targeting, to, from or within Golgi | 20/7958 | 21/18723 | 4.57e-07 | 7.50e-06 | 20 |
GO:005164821 | Liver | HCC | vesicle localization | 107/7958 | 177/18723 | 1.05e-06 | 1.57e-05 | 107 |
GO:005122511 | Liver | HCC | spindle assembly | 75/7958 | 117/18723 | 1.92e-06 | 2.67e-05 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP19 | SNV | Missense_Mutation | c.264N>C | p.Gln88His | p.Q88H | Q96LK0 | protein_coding | tolerated(0.55) | benign(0.055) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CEP19 | SNV | Missense_Mutation | c.470G>T | p.Cys157Phe | p.C157F | Q96LK0 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-E9-A1NF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
CEP19 | SNV | Missense_Mutation | rs201883289 | c.245G>C | p.Arg82Pro | p.R82P | Q96LK0 | protein_coding | deleterious(0.01) | possibly_damaging(0.737) | TCGA-IR-A3LB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CEP19 | SNV | Missense_Mutation | novel | c.122N>A | p.Arg41Gln | p.R41Q | Q96LK0 | protein_coding | deleterious(0.04) | probably_damaging(0.962) | TCGA-AA-3526-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CEP19 | SNV | Missense_Mutation | c.101G>T | p.Arg34Leu | p.R34L | Q96LK0 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CEP19 | SNV | Missense_Mutation | c.418N>A | p.Phe140Ile | p.F140I | Q96LK0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CEP19 | SNV | Missense_Mutation | novel | c.44N>T | p.Arg15Met | p.R15M | Q96LK0 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CEP19 | SNV | Missense_Mutation | novel | c.467C>A | p.Ser156Tyr | p.S156Y | Q96LK0 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CEP19 | SNV | Missense_Mutation | novel | c.271G>A | p.Ala91Thr | p.A91T | Q96LK0 | protein_coding | tolerated(0.53) | benign(0.007) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CEP19 | SNV | Missense_Mutation | rs374921346 | c.107G>A | p.Arg36His | p.R36H | Q96LK0 | protein_coding | tolerated(0.1) | possibly_damaging(0.574) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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