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Gene: CDC6 |
Gene summary for CDC6 |
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Gene information | Species | Human | Gene symbol | CDC6 | Gene ID | 990 |
Gene name | cell division cycle 6 | |
Gene Alias | CDC18L | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0A024R1S2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
990 | CDC6 | LZE6T | Human | Esophagus | ESCC | 7.44e-03 | 1.94e-01 | 0.0845 |
990 | CDC6 | P2T-E | Human | Esophagus | ESCC | 4.64e-07 | 3.67e-01 | 0.1177 |
990 | CDC6 | P4T-E | Human | Esophagus | ESCC | 8.08e-06 | 2.76e-01 | 0.1323 |
990 | CDC6 | P5T-E | Human | Esophagus | ESCC | 1.15e-17 | 3.77e-01 | 0.1327 |
990 | CDC6 | P16T-E | Human | Esophagus | ESCC | 4.56e-06 | 2.54e-01 | 0.1153 |
990 | CDC6 | P17T-E | Human | Esophagus | ESCC | 4.22e-02 | 3.63e-01 | 0.1278 |
990 | CDC6 | P21T-E | Human | Esophagus | ESCC | 6.75e-05 | 2.33e-01 | 0.1617 |
990 | CDC6 | P22T-E | Human | Esophagus | ESCC | 2.93e-03 | 1.35e-01 | 0.1236 |
990 | CDC6 | P23T-E | Human | Esophagus | ESCC | 1.74e-02 | 2.05e-01 | 0.108 |
990 | CDC6 | P24T-E | Human | Esophagus | ESCC | 1.32e-04 | 2.01e-01 | 0.1287 |
990 | CDC6 | P27T-E | Human | Esophagus | ESCC | 6.22e-04 | 1.50e-01 | 0.1055 |
990 | CDC6 | P28T-E | Human | Esophagus | ESCC | 4.38e-07 | 2.61e-01 | 0.1149 |
990 | CDC6 | P31T-E | Human | Esophagus | ESCC | 1.77e-13 | 4.69e-01 | 0.1251 |
990 | CDC6 | P32T-E | Human | Esophagus | ESCC | 7.53e-12 | 3.82e-01 | 0.1666 |
990 | CDC6 | P36T-E | Human | Esophagus | ESCC | 3.01e-06 | 3.89e-01 | 0.1187 |
990 | CDC6 | P37T-E | Human | Esophagus | ESCC | 1.60e-09 | 3.51e-01 | 0.1371 |
990 | CDC6 | P38T-E | Human | Esophagus | ESCC | 3.86e-05 | 3.09e-01 | 0.127 |
990 | CDC6 | P39T-E | Human | Esophagus | ESCC | 2.76e-03 | 1.56e-01 | 0.0894 |
990 | CDC6 | P47T-E | Human | Esophagus | ESCC | 2.17e-02 | 3.16e-02 | 0.1067 |
990 | CDC6 | P52T-E | Human | Esophagus | ESCC | 1.02e-20 | 5.25e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00109721 | Esophagus | ESCC | negative regulation of G2/M transition of mitotic cell cycle | 41/8552 | 60/18723 | 3.25e-04 | 1.91e-03 | 41 |
GO:19027501 | Esophagus | ESCC | negative regulation of cell cycle G2/M phase transition | 42/8552 | 62/18723 | 3.69e-04 | 2.14e-03 | 42 |
GO:00448181 | Esophagus | ESCC | mitotic G2/M transition checkpoint | 32/8552 | 46/18723 | 9.01e-04 | 4.61e-03 | 32 |
GO:00324653 | Esophagus | ESCC | regulation of cytokinesis | 57/8552 | 92/18723 | 1.20e-03 | 5.88e-03 | 57 |
GO:200004513 | Esophagus | ESCC | regulation of G1/S transition of mitotic cell cycle | 82/8552 | 142/18723 | 2.49e-03 | 1.08e-02 | 82 |
GO:00519842 | Esophagus | ESCC | positive regulation of chromosome segregation | 12/8552 | 14/18723 | 2.51e-03 | 1.08e-02 | 12 |
GO:00481464 | Esophagus | ESCC | positive regulation of fibroblast proliferation | 32/8552 | 48/18723 | 2.70e-03 | 1.14e-02 | 32 |
GO:190280613 | Esophagus | ESCC | regulation of cell cycle G1/S phase transition | 95/8552 | 168/18723 | 2.91e-03 | 1.22e-02 | 95 |
GO:00513025 | Esophagus | ESCC | regulation of cell division | 97/8552 | 177/18723 | 8.93e-03 | 3.12e-02 | 97 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:005122511 | Liver | HCC | spindle assembly | 75/7958 | 117/18723 | 1.92e-06 | 2.67e-05 | 75 |
GO:01400145 | Oral cavity | OSCC | mitotic nuclear division | 191/7305 | 287/18723 | 1.99e-21 | 3.70e-19 | 191 |
GO:00447728 | Oral cavity | OSCC | mitotic cell cycle phase transition | 255/7305 | 424/18723 | 5.29e-19 | 6.98e-17 | 255 |
GO:00073469 | Oral cavity | OSCC | regulation of mitotic cell cycle | 266/7305 | 457/18723 | 3.87e-17 | 3.41e-15 | 266 |
GO:00000702 | Oral cavity | OSCC | mitotic sister chromatid segregation | 118/7305 | 168/18723 | 1.89e-16 | 1.48e-14 | 118 |
GO:00008193 | Oral cavity | OSCC | sister chromatid segregation | 135/7305 | 202/18723 | 8.88e-16 | 6.52e-14 | 135 |
GO:00070592 | Oral cavity | OSCC | chromosome segregation | 206/7305 | 346/18723 | 5.82e-15 | 3.76e-13 | 206 |
GO:00330448 | Oral cavity | OSCC | regulation of chromosome organization | 123/7305 | 187/18723 | 9.87e-14 | 5.17e-12 | 123 |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC6 | SNV | Missense_Mutation | c.1324N>C | p.Asp442His | p.D442H | Q99741 | protein_coding | tolerated(0.19) | benign(0.231) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
CDC6 | SNV | Missense_Mutation | c.1639N>C | p.Asp547His | p.D547H | Q99741 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
CDC6 | insertion | Frame_Shift_Ins | novel | c.512_513insCCAA | p.Leu172GlnfsTer57 | p.L172Qfs*57 | Q99741 | protein_coding | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | ||
CDC6 | insertion | Nonsense_Mutation | novel | c.514_515insCTGGCTAATT | p.Leu172ProfsTer3 | p.L172Pfs*3 | Q99741 | protein_coding | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | ||
CDC6 | SNV | Missense_Mutation | novel | c.1576G>A | p.Glu526Lys | p.E526K | Q99741 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CDC6 | SNV | Missense_Mutation | c.1566G>C | p.Lys522Asn | p.K522N | Q99741 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
CDC6 | SNV | Missense_Mutation | rs757198932 | c.511N>T | p.Arg171Trp | p.R171W | Q99741 | protein_coding | deleterious(0) | possibly_damaging(0.513) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDC6 | SNV | Missense_Mutation | novel | c.386N>G | p.Glu129Gly | p.E129G | Q99741 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CDC6 | SNV | Missense_Mutation | novel | c.1404N>T | p.Leu468Phe | p.L468F | Q99741 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC6 | SNV | Missense_Mutation | c.529N>T | p.Arg177Trp | p.R177W | Q99741 | protein_coding | deleterious(0) | benign(0.068) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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