GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009719320 | Oral cavity | OSCC | intrinsic apoptotic signaling pathway | 202/7305 | 288/18723 | 4.64e-27 | 1.73e-24 | 202 |
GO:004586220 | Oral cavity | OSCC | positive regulation of proteolysis | 236/7305 | 372/18723 | 6.53e-22 | 1.38e-19 | 236 |
GO:00447728 | Oral cavity | OSCC | mitotic cell cycle phase transition | 255/7305 | 424/18723 | 5.29e-19 | 6.98e-17 | 255 |
GO:00073469 | Oral cavity | OSCC | regulation of mitotic cell cycle | 266/7305 | 457/18723 | 3.87e-17 | 3.41e-15 | 266 |
GO:200011620 | Oral cavity | OSCC | regulation of cysteine-type endopeptidase activity | 152/7305 | 235/18723 | 1.14e-15 | 8.13e-14 | 152 |
GO:004328120 | Oral cavity | OSCC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 137/7305 | 209/18723 | 5.94e-15 | 3.80e-13 | 137 |
GO:009719120 | Oral cavity | OSCC | extrinsic apoptotic signaling pathway | 142/7305 | 219/18723 | 7.34e-15 | 4.55e-13 | 142 |
GO:200123510 | Oral cavity | OSCC | positive regulation of apoptotic signaling pathway | 92/7305 | 126/18723 | 8.45e-15 | 5.19e-13 | 92 |
GO:005254720 | Oral cavity | OSCC | regulation of peptidase activity | 255/7305 | 461/18723 | 5.78e-13 | 2.75e-11 | 255 |
GO:007149620 | Oral cavity | OSCC | cellular response to external stimulus | 186/7305 | 320/18723 | 2.56e-12 | 1.05e-10 | 186 |
GO:007233120 | Oral cavity | OSCC | signal transduction by p53 class mediator | 107/7305 | 163/18723 | 4.75e-12 | 1.83e-10 | 107 |
GO:000756818 | Oral cavity | OSCC | aging | 194/7305 | 339/18723 | 6.18e-12 | 2.33e-10 | 194 |
GO:000863018 | Oral cavity | OSCC | intrinsic apoptotic signaling pathway in response to DNA damage | 72/7305 | 99/18723 | 9.50e-12 | 3.50e-10 | 72 |
GO:001095220 | Oral cavity | OSCC | positive regulation of peptidase activity | 123/7305 | 197/18723 | 2.12e-11 | 7.21e-10 | 123 |
GO:19019905 | Oral cavity | OSCC | regulation of mitotic cell cycle phase transition | 173/7305 | 299/18723 | 2.49e-11 | 8.35e-10 | 173 |
GO:007099720 | Oral cavity | OSCC | neuron death | 202/7305 | 361/18723 | 3.75e-11 | 1.23e-09 | 202 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:005254820 | Oral cavity | OSCC | regulation of endopeptidase activity | 235/7305 | 432/18723 | 4.35e-11 | 1.40e-09 | 235 |
GO:007121416 | Oral cavity | OSCC | cellular response to abiotic stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
GO:010400416 | Oral cavity | OSCC | cellular response to environmental stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CASP2 | SNV | Missense_Mutation | | c.23N>T | p.Ser8Phe | p.S8F | P42575 | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CASP2 | SNV | Missense_Mutation | novel | c.905N>G | p.Asn302Ser | p.N302S | P42575 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-A2-A4RY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR |
CASP2 | insertion | In_Frame_Ins | novel | c.553_554insAAACACACTTCCAGCTGGTGAGTTTTTGCATAA | p.Leu190_Ala191insValSerPheCysIleLysThrHisPheGlnLeu | p.L190_A191insVSFCIKTHFQL | P42575 | protein_coding | | | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
CASP2 | SNV | Missense_Mutation | | c.249N>C | p.Gln83His | p.Q83H | P42575 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-IR-A3LF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CASP2 | SNV | Missense_Mutation | rs139233385 | c.794N>A | p.Arg265Gln | p.R265Q | P42575 | protein_coding | tolerated(0.28) | benign(0.011) | TCGA-VS-A9U5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CASP2 | insertion | Frame_Shift_Ins | novel | c.3_4insGCGGC | p.Pro4ArgfsTer16 | p.P4Rfs*16 | P42575 | protein_coding | | | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
CASP2 | SNV | Missense_Mutation | rs756201685 | c.907N>A | p.Ala303Thr | p.A303T | P42575 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CASP2 | SNV | Missense_Mutation | rs144817015 | c.464N>A | p.Arg155His | p.R155H | P42575 | protein_coding | tolerated(0.22) | benign(0.01) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CASP2 | SNV | Missense_Mutation | rs141615673 | c.718G>A | p.Val240Ile | p.V240I | P42575 | protein_coding | deleterious(0.05) | benign(0.029) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CASP2 | SNV | Missense_Mutation | rs370097426 | c.814N>A | p.Val272Met | p.V272M | P42575 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
835 | CASP2 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL197672 | EMRICASAN | |
835 | CASP2 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166828 | | |
835 | CASP2 | PROTEASE, DRUGGABLE GENOME, ENZYME | | CETYLPYRIDINIUM CHLORIDE | CETYLPYRIDINIUM CHLORIDE | 18366176 |
835 | CASP2 | PROTEASE, DRUGGABLE GENOME, ENZYME | | SPERMINE | SPERMINE | 18366176 |
835 | CASP2 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178101981 | | |
835 | CASP2 | PROTEASE, DRUGGABLE GENOME, ENZYME | | N-DECYLBUTYRAMIDE | CHEMBL265439 | 18366176 |