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Gene: BMPR1A |
Gene summary for BMPR1A |
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Gene information | Species | Human | Gene symbol | BMPR1A | Gene ID | 657 |
Gene name | bone morphogenetic protein receptor type 1A | |
Gene Alias | 10q23del | |
Cytomap | 10q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P36894 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
657 | BMPR1A | CCI_1 | Human | Cervix | CC | 1.95e-04 | 5.46e-01 | 0.528 |
657 | BMPR1A | CCI_2 | Human | Cervix | CC | 6.52e-04 | 7.77e-01 | 0.5249 |
657 | BMPR1A | CCI_3 | Human | Cervix | CC | 3.18e-02 | 3.94e-01 | 0.516 |
657 | BMPR1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.50e-07 | -4.03e-01 | 0.0155 |
657 | BMPR1A | HTA11_83_2000001011 | Human | Colorectum | SER | 9.73e-04 | -2.39e-01 | -0.1526 |
657 | BMPR1A | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.67e-02 | -5.75e-01 | -0.2061 |
657 | BMPR1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.08e-04 | -2.85e-01 | 0.0674 |
657 | BMPR1A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.33e-09 | -4.33e-01 | 0.3005 |
657 | BMPR1A | A001-C-207 | Human | Colorectum | FAP | 3.52e-02 | -3.04e-01 | 0.1278 |
657 | BMPR1A | A015-C-203 | Human | Colorectum | FAP | 1.52e-31 | -5.15e-01 | -0.1294 |
657 | BMPR1A | A015-C-204 | Human | Colorectum | FAP | 1.45e-05 | -2.90e-01 | -0.0228 |
657 | BMPR1A | A014-C-040 | Human | Colorectum | FAP | 3.34e-02 | -1.10e-01 | -0.1184 |
657 | BMPR1A | A002-C-201 | Human | Colorectum | FAP | 2.11e-13 | -4.52e-01 | 0.0324 |
657 | BMPR1A | A002-C-203 | Human | Colorectum | FAP | 1.67e-02 | -1.33e-01 | 0.2786 |
657 | BMPR1A | A001-C-119 | Human | Colorectum | FAP | 3.18e-11 | -5.76e-01 | -0.1557 |
657 | BMPR1A | A001-C-108 | Human | Colorectum | FAP | 3.66e-21 | -3.77e-01 | -0.0272 |
657 | BMPR1A | A002-C-205 | Human | Colorectum | FAP | 1.69e-18 | -4.09e-01 | -0.1236 |
657 | BMPR1A | A001-C-104 | Human | Colorectum | FAP | 4.87e-04 | -2.73e-01 | 0.0184 |
657 | BMPR1A | A015-C-006 | Human | Colorectum | FAP | 1.47e-13 | -5.33e-01 | -0.0994 |
657 | BMPR1A | A015-C-106 | Human | Colorectum | FAP | 3.87e-14 | -3.58e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487624 | Cervix | CC | mesenchymal cell differentiation | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:0030282 | Cervix | CC | bone mineralization | 24/2311 | 119/18723 | 1.00e-02 | 4.89e-02 | 24 |
GO:0110148 | Cervix | CC | biomineralization | 32/2311 | 171/18723 | 1.04e-02 | 4.97e-02 | 32 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0061614 | Colorectum | AD | pri-miRNA transcription by RNA polymerase II | 24/3918 | 55/18723 | 1.22e-04 | 1.78e-03 | 24 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:1902893 | Colorectum | AD | regulation of pri-miRNA transcription by RNA polymerase II | 23/3918 | 54/18723 | 2.60e-04 | 3.25e-03 | 23 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0001649 | Colorectum | AD | osteoblast differentiation | 70/3918 | 229/18723 | 3.59e-04 | 4.18e-03 | 70 |
GO:0045927 | Colorectum | AD | positive regulation of growth | 77/3918 | 259/18723 | 4.82e-04 | 5.27e-03 | 77 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0048638 | Colorectum | AD | regulation of developmental growth | 92/3918 | 330/18723 | 1.48e-03 | 1.25e-02 | 92 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:0007179 | Colorectum | AD | transforming growth factor beta receptor signaling pathway | 59/3918 | 198/18723 | 1.94e-03 | 1.58e-02 | 59 |
GO:0060390 | Colorectum | AD | regulation of SMAD protein signal transduction | 14/3918 | 31/18723 | 2.10e-03 | 1.67e-02 | 14 |
GO:0071900 | Colorectum | AD | regulation of protein serine/threonine kinase activity | 98/3918 | 359/18723 | 2.18e-03 | 1.73e-02 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541820 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa05418110 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa05418 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa054181 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa054182 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa054183 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa054184 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa054185 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa054188 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa054189 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa0541810 | Colorectum | CRC | Fluid shear stress and atherosclerosis | 32/1091 | 139/8465 | 6.52e-04 | 5.89e-03 | 3.99e-03 | 32 |
hsa043904 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Cervix | CC |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP4 | BMPR1A_BMPR2 | BMP4_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP6 | BMPR1A_BMPR2 | BMP6_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP4 | BMPR1A_ACVR2A | BMP4_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP4 | BMPR1A_BMPR2 | BMP4_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP6 | BMPR1A_ACVR2A | BMP6_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP6 | BMPR1A_BMPR2 | BMP6_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | CRC |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | FAP |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | FAP |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | CRC | FAP |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | FAP |
BMP6 | BMPR1A_ACVR2A | BMP6_BMPR1A_ACVR2A | BMP | CRC | FAP |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMPR1A | SNV | Missense_Mutation | rs755740570 | c.779N>G | p.Val260Gly | p.V260G | P36894 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-A2-A25F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
BMPR1A | SNV | Missense_Mutation | novel | c.11N>A | p.Leu4Gln | p.L4Q | P36894 | protein_coding | deleterious_low_confidence(0.02) | benign(0.135) | TCGA-A7-A426-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
BMPR1A | SNV | Missense_Mutation | rs755740570 | c.779T>G | p.Val260Gly | p.V260G | P36894 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-BH-A1FR-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
BMPR1A | SNV | Missense_Mutation | rs755740570 | c.779N>G | p.Val260Gly | p.V260G | P36894 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
BMPR1A | SNV | Missense_Mutation | rs786202611 | c.1231G>A | p.Glu411Lys | p.E411K | P36894 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMPR1A | SNV | Missense_Mutation | c.856G>A | p.Glu286Lys | p.E286K | P36894 | protein_coding | tolerated(0.09) | benign(0.246) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
BMPR1A | SNV | Missense_Mutation | c.734N>G | p.Tyr245Cys | p.Y245C | P36894 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BMPR1A | SNV | Missense_Mutation | rs758309022 | c.1379N>C | p.Met460Thr | p.M460T | P36894 | protein_coding | tolerated(0.07) | possibly_damaging(0.491) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BMPR1A | SNV | Missense_Mutation | c.1561C>T | p.Leu521Phe | p.L521F | P36894 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
BMPR1A | SNV | Missense_Mutation | novel | c.55N>G | p.Ser19Ala | p.S19A | P36894 | protein_coding | tolerated_low_confidence(0.5) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565824 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 252166689 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565800 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565835 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565801 |
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