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Gene: BICD2 |
Gene summary for BICD2 |
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Gene information | Species | Human | Gene symbol | BICD2 | Gene ID | 23299 |
Gene name | BICD cargo adaptor 2 | |
Gene Alias | SMALED2 | |
Cytomap | 9q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8TD16 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23299 | BICD2 | LZE4T | Human | Esophagus | ESCC | 4.71e-10 | 2.29e-01 | 0.0811 |
23299 | BICD2 | LZE8T | Human | Esophagus | ESCC | 3.11e-08 | -1.83e-01 | 0.067 |
23299 | BICD2 | LZE20T | Human | Esophagus | ESCC | 3.21e-04 | -3.19e-01 | 0.0662 |
23299 | BICD2 | LZE22T | Human | Esophagus | ESCC | 2.61e-06 | -2.29e-02 | 0.068 |
23299 | BICD2 | LZE24T | Human | Esophagus | ESCC | 4.54e-06 | -3.47e-02 | 0.0596 |
23299 | BICD2 | P1T-E | Human | Esophagus | ESCC | 1.18e-08 | -9.00e-02 | 0.0875 |
23299 | BICD2 | P2T-E | Human | Esophagus | ESCC | 4.62e-22 | 2.18e-01 | 0.1177 |
23299 | BICD2 | P4T-E | Human | Esophagus | ESCC | 1.36e-17 | 2.70e-02 | 0.1323 |
23299 | BICD2 | P5T-E | Human | Esophagus | ESCC | 1.67e-13 | 5.72e-02 | 0.1327 |
23299 | BICD2 | P8T-E | Human | Esophagus | ESCC | 3.01e-09 | -1.67e-01 | 0.0889 |
23299 | BICD2 | P9T-E | Human | Esophagus | ESCC | 8.00e-17 | 1.98e-01 | 0.1131 |
23299 | BICD2 | P10T-E | Human | Esophagus | ESCC | 7.57e-22 | 5.00e-01 | 0.116 |
23299 | BICD2 | P11T-E | Human | Esophagus | ESCC | 1.43e-07 | 2.25e-01 | 0.1426 |
23299 | BICD2 | P12T-E | Human | Esophagus | ESCC | 6.55e-21 | 4.08e-01 | 0.1122 |
23299 | BICD2 | P15T-E | Human | Esophagus | ESCC | 4.43e-21 | 3.63e-01 | 0.1149 |
23299 | BICD2 | P16T-E | Human | Esophagus | ESCC | 1.46e-13 | -2.47e-01 | 0.1153 |
23299 | BICD2 | P17T-E | Human | Esophagus | ESCC | 1.41e-05 | -6.51e-02 | 0.1278 |
23299 | BICD2 | P19T-E | Human | Esophagus | ESCC | 1.17e-02 | 2.60e-01 | 0.1662 |
23299 | BICD2 | P20T-E | Human | Esophagus | ESCC | 5.35e-19 | 2.24e-01 | 0.1124 |
23299 | BICD2 | P21T-E | Human | Esophagus | ESCC | 4.02e-22 | 6.46e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068909 | Prostate | BPH | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 21/3107 | 52/18723 | 3.85e-05 | 4.18e-04 | 21 |
GO:00328862 | Prostate | BPH | regulation of microtubule-based process | 64/3107 | 240/18723 | 4.93e-05 | 5.11e-04 | 64 |
GO:00340674 | Prostate | BPH | protein localization to Golgi apparatus | 14/3107 | 29/18723 | 7.48e-05 | 7.24e-04 | 14 |
GO:00618426 | Prostate | BPH | microtubule organizing center localization | 14/3107 | 33/18723 | 4.08e-04 | 2.97e-03 | 14 |
GO:00991112 | Prostate | BPH | microtubule-based transport | 49/3107 | 190/18723 | 8.05e-04 | 5.27e-03 | 49 |
GO:00723844 | Prostate | BPH | organelle transport along microtubule | 26/3107 | 85/18723 | 9.92e-04 | 6.24e-03 | 26 |
GO:00516426 | Prostate | BPH | centrosome localization | 13/3107 | 32/18723 | 1.07e-03 | 6.67e-03 | 13 |
GO:001593110 | Prostate | BPH | nucleobase-containing compound transport | 55/3107 | 222/18723 | 1.12e-03 | 6.97e-03 | 55 |
GO:00510286 | Prostate | BPH | mRNA transport | 35/3107 | 130/18723 | 1.93e-03 | 1.10e-02 | 35 |
GO:004819314 | Prostate | Tumor | Golgi vesicle transport | 105/3246 | 296/18723 | 3.55e-14 | 4.33e-12 | 105 |
GO:000640317 | Prostate | Tumor | RNA localization | 70/3246 | 201/18723 | 1.58e-09 | 7.32e-08 | 70 |
GO:003070515 | Prostate | Tumor | cytoskeleton-dependent intracellular transport | 67/3246 | 195/18723 | 6.56e-09 | 2.53e-07 | 67 |
GO:005165614 | Prostate | Tumor | establishment of organelle localization | 109/3246 | 390/18723 | 9.97e-08 | 2.67e-06 | 109 |
GO:005123613 | Prostate | Tumor | establishment of RNA localization | 52/3246 | 166/18723 | 7.11e-06 | 1.07e-04 | 52 |
GO:005065713 | Prostate | Tumor | nucleic acid transport | 51/3246 | 163/18723 | 8.99e-06 | 1.32e-04 | 51 |
GO:005065813 | Prostate | Tumor | RNA transport | 51/3246 | 163/18723 | 8.99e-06 | 1.32e-04 | 51 |
GO:007050714 | Prostate | Tumor | regulation of microtubule cytoskeleton organization | 47/3246 | 148/18723 | 1.29e-05 | 1.78e-04 | 47 |
GO:001097011 | Prostate | Tumor | transport along microtubule | 48/3246 | 155/18723 | 2.20e-05 | 2.80e-04 | 48 |
GO:003406712 | Prostate | Tumor | protein localization to Golgi apparatus | 15/3246 | 29/18723 | 2.48e-05 | 3.10e-04 | 15 |
GO:000689014 | Prostate | Tumor | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 21/3246 | 52/18723 | 7.49e-05 | 7.85e-04 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa032508 | Oral cavity | OSCC | Viral life cycle - HIV-1 | 45/3704 | 63/8465 | 7.62e-06 | 3.59e-05 | 1.83e-05 | 45 |
hsa0325013 | Oral cavity | OSCC | Viral life cycle - HIV-1 | 45/3704 | 63/8465 | 7.62e-06 | 3.59e-05 | 1.83e-05 | 45 |
hsa0325022 | Oral cavity | LP | Viral life cycle - HIV-1 | 32/2418 | 63/8465 | 1.55e-04 | 9.08e-04 | 5.86e-04 | 32 |
hsa0325031 | Oral cavity | LP | Viral life cycle - HIV-1 | 32/2418 | 63/8465 | 1.55e-04 | 9.08e-04 | 5.86e-04 | 32 |
hsa032504 | Prostate | BPH | Viral life cycle - HIV-1 | 24/1718 | 63/8465 | 8.32e-04 | 3.98e-03 | 2.46e-03 | 24 |
hsa0325012 | Prostate | BPH | Viral life cycle - HIV-1 | 24/1718 | 63/8465 | 8.32e-04 | 3.98e-03 | 2.46e-03 | 24 |
hsa0325021 | Prostate | Tumor | Viral life cycle - HIV-1 | 25/1791 | 63/8465 | 6.13e-04 | 3.07e-03 | 1.91e-03 | 25 |
hsa032503 | Prostate | Tumor | Viral life cycle - HIV-1 | 25/1791 | 63/8465 | 6.13e-04 | 3.07e-03 | 1.91e-03 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BICD2 | SNV | Missense_Mutation | rs201997144 | c.1348C>T | p.Arg450Cys | p.R450C | Q8TD16 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
BICD2 | SNV | Missense_Mutation | rs765563734 | c.1489G>A | p.Glu497Lys | p.E497K | Q8TD16 | protein_coding | deleterious(0.01) | benign(0.401) | TCGA-DS-A5RQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
BICD2 | SNV | Missense_Mutation | c.2407N>G | p.His803Asp | p.H803D | Q8TD16 | protein_coding | deleterious(0.04) | benign(0.356) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
BICD2 | SNV | Missense_Mutation | c.2354N>T | p.Ala785Val | p.A785V | Q8TD16 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
BICD2 | SNV | Missense_Mutation | rs776528966 | c.1733N>A | p.Arg578His | p.R578H | Q8TD16 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
BICD2 | SNV | Missense_Mutation | c.2384G>A | p.Arg795Gln | p.R795Q | Q8TD16 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
BICD2 | SNV | Missense_Mutation | novel | c.844N>C | p.Gly282Arg | p.G282R | Q8TD16 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
BICD2 | SNV | Missense_Mutation | c.2510N>C | p.Gly837Ala | p.G837A | Q8TD16 | protein_coding | tolerated_low_confidence(0.26) | benign(0.001) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR | |
BICD2 | SNV | Missense_Mutation | c.1531G>A | p.Asp511Asn | p.D511N | Q8TD16 | protein_coding | tolerated(0.36) | possibly_damaging(0.561) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
BICD2 | SNV | Missense_Mutation | rs761506224 | c.485G>A | p.Arg162His | p.R162H | Q8TD16 | protein_coding | tolerated(0.25) | possibly_damaging(0.814) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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