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Gene: BET1 |
Gene summary for BET1 |
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Gene information | Species | Human | Gene symbol | BET1 | Gene ID | 10282 |
Gene name | Bet1 golgi vesicular membrane trafficking protein | |
Gene Alias | HBET1 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O15155 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10282 | BET1 | LZE4T | Human | Esophagus | ESCC | 6.39e-12 | 2.94e-01 | 0.0811 |
10282 | BET1 | LZE5T | Human | Esophagus | ESCC | 4.09e-02 | 2.49e-01 | 0.0514 |
10282 | BET1 | LZE7T | Human | Esophagus | ESCC | 8.44e-03 | 9.06e-02 | 0.0667 |
10282 | BET1 | LZE8T | Human | Esophagus | ESCC | 1.38e-02 | 6.95e-02 | 0.067 |
10282 | BET1 | LZE20T | Human | Esophagus | ESCC | 1.53e-11 | 3.87e-01 | 0.0662 |
10282 | BET1 | LZE24T | Human | Esophagus | ESCC | 1.82e-18 | 4.42e-01 | 0.0596 |
10282 | BET1 | LZE6T | Human | Esophagus | ESCC | 1.03e-04 | 3.24e-01 | 0.0845 |
10282 | BET1 | P1T-E | Human | Esophagus | ESCC | 6.42e-12 | 5.97e-01 | 0.0875 |
10282 | BET1 | P2T-E | Human | Esophagus | ESCC | 1.17e-28 | 6.10e-01 | 0.1177 |
10282 | BET1 | P4T-E | Human | Esophagus | ESCC | 3.38e-32 | 6.91e-01 | 0.1323 |
10282 | BET1 | P5T-E | Human | Esophagus | ESCC | 1.92e-26 | 4.56e-01 | 0.1327 |
10282 | BET1 | P8T-E | Human | Esophagus | ESCC | 1.66e-29 | 3.99e-01 | 0.0889 |
10282 | BET1 | P9T-E | Human | Esophagus | ESCC | 1.13e-23 | 4.76e-01 | 0.1131 |
10282 | BET1 | P10T-E | Human | Esophagus | ESCC | 2.24e-32 | 4.46e-01 | 0.116 |
10282 | BET1 | P11T-E | Human | Esophagus | ESCC | 1.85e-20 | 1.11e+00 | 0.1426 |
10282 | BET1 | P12T-E | Human | Esophagus | ESCC | 2.97e-39 | 6.61e-01 | 0.1122 |
10282 | BET1 | P15T-E | Human | Esophagus | ESCC | 3.95e-24 | 5.84e-01 | 0.1149 |
10282 | BET1 | P16T-E | Human | Esophagus | ESCC | 3.09e-73 | 1.22e+00 | 0.1153 |
10282 | BET1 | P17T-E | Human | Esophagus | ESCC | 2.57e-20 | 9.59e-01 | 0.1278 |
10282 | BET1 | P19T-E | Human | Esophagus | ESCC | 5.12e-06 | 7.92e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482802 | Oral cavity | OSCC | vesicle fusion with Golgi apparatus | 9/7305 | 10/18723 | 1.36e-03 | 6.62e-03 | 9 |
GO:004819316 | Oral cavity | LP | Golgi vesicle transport | 141/4623 | 296/18723 | 6.11e-18 | 1.06e-15 | 141 |
GO:001605013 | Oral cavity | LP | vesicle organization | 128/4623 | 300/18723 | 4.96e-12 | 3.98e-10 | 128 |
GO:000688814 | Oral cavity | LP | endoplasmic reticulum to Golgi vesicle-mediated transport | 67/4623 | 130/18723 | 3.74e-11 | 2.39e-09 | 67 |
GO:001619714 | Oral cavity | LP | endosomal transport | 98/4623 | 230/18723 | 1.65e-09 | 7.50e-08 | 98 |
GO:000689015 | Oral cavity | LP | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 29/4623 | 52/18723 | 1.60e-06 | 3.79e-05 | 29 |
GO:001648214 | Oral cavity | LP | cytosolic transport | 69/4623 | 168/18723 | 2.03e-06 | 4.65e-05 | 69 |
GO:004828412 | Oral cavity | LP | organelle fusion | 56/4623 | 141/18723 | 5.55e-05 | 7.62e-04 | 56 |
GO:000690611 | Oral cavity | LP | vesicle fusion | 44/4623 | 106/18723 | 1.01e-04 | 1.24e-03 | 44 |
GO:009017411 | Oral cavity | LP | organelle membrane fusion | 45/4623 | 110/18723 | 1.28e-04 | 1.49e-03 | 45 |
GO:00610251 | Oral cavity | LP | membrane fusion | 58/4623 | 163/18723 | 1.19e-03 | 9.62e-03 | 58 |
GO:004214713 | Oral cavity | LP | retrograde transport, endosome to Golgi | 36/4623 | 91/18723 | 1.20e-03 | 9.67e-03 | 36 |
GO:004819314 | Prostate | Tumor | Golgi vesicle transport | 105/3246 | 296/18723 | 3.55e-14 | 4.33e-12 | 105 |
GO:000688813 | Prostate | Tumor | endoplasmic reticulum to Golgi vesicle-mediated transport | 49/3246 | 130/18723 | 2.49e-08 | 8.33e-07 | 49 |
GO:001605012 | Prostate | Tumor | vesicle organization | 87/3246 | 300/18723 | 3.44e-07 | 7.71e-06 | 87 |
GO:000703013 | Prostate | Tumor | Golgi organization | 40/3246 | 157/18723 | 6.33e-03 | 2.90e-02 | 40 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:000688810 | Skin | cSCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 73/4864 | 130/18723 | 2.60e-13 | 1.57e-11 | 73 |
GO:001605015 | Skin | cSCC | vesicle organization | 135/4864 | 300/18723 | 5.98e-13 | 3.44e-11 | 135 |
GO:00482845 | Skin | cSCC | organelle fusion | 60/4864 | 141/18723 | 1.32e-05 | 1.67e-04 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041305 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa0413012 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa04130 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa041301 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa041302 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
hsa041303 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BET1 | SNV | Missense_Mutation | c.13N>T | p.Gly5Cys | p.G5C | O15155 | protein_coding | deleterious(0.01) | benign(0.286) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
BET1 | SNV | Missense_Mutation | novel | c.42N>A | p.Asn14Lys | p.N14K | O15155 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BET1 | SNV | Missense_Mutation | c.101G>T | p.Arg34Met | p.R34M | O15155 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BET1 | SNV | Missense_Mutation | novel | c.311N>A | p.Ser104Tyr | p.S104Y | O15155 | protein_coding | deleterious(0) | possibly_damaging(0.547) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BET1 | SNV | Missense_Mutation | novel | c.258N>T | p.Lys86Asn | p.K86N | O15155 | protein_coding | tolerated(0.36) | benign(0.043) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BET1 | SNV | Missense_Mutation | c.202G>A | p.Asp68Asn | p.D68N | O15155 | protein_coding | tolerated(0.09) | benign(0.257) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
BET1 | SNV | Missense_Mutation | rs775800524 | c.227N>A | p.Gly76Glu | p.G76E | O15155 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
BET1 | SNV | Missense_Mutation | c.143C>A | p.Ser48Tyr | p.S48Y | O15155 | protein_coding | deleterious(0.02) | benign(0.2) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BET1 | SNV | Missense_Mutation | novel | c.98N>C | p.Glu33Ala | p.E33A | O15155 | protein_coding | deleterious(0.01) | benign(0.226) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
BET1 | SNV | Missense_Mutation | novel | c.242C>A | p.Thr81Asn | p.T81N | O15155 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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