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Gene: BANF1 |
Gene summary for BANF1 |
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Gene information | Species | Human | Gene symbol | BANF1 | Gene ID | 8815 |
Gene name | BAF nuclear assembly factor 1 | |
Gene Alias | BAF | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | A0A024R5H0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8815 | BANF1 | CA_HPV_1 | Human | Cervix | CC | 3.24e-04 | -1.11e-01 | 0.0264 |
8815 | BANF1 | CA_HPV_3 | Human | Cervix | CC | 7.75e-05 | 1.93e-01 | 0.0414 |
8815 | BANF1 | CCI_1 | Human | Cervix | CC | 1.10e-03 | -5.08e-01 | 0.528 |
8815 | BANF1 | CCI_3 | Human | Cervix | CC | 2.22e-06 | -5.22e-01 | 0.516 |
8815 | BANF1 | CCII_1 | Human | Cervix | CC | 1.00e-11 | -5.46e-01 | 0.3249 |
8815 | BANF1 | L1 | Human | Cervix | CC | 2.89e-06 | 1.73e-02 | 0.0802 |
8815 | BANF1 | T3 | Human | Cervix | CC | 7.60e-03 | 1.51e-01 | 0.1389 |
8815 | BANF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.70e-19 | 4.06e-01 | 0.0155 |
8815 | BANF1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.45e-16 | 4.86e-01 | -0.1808 |
8815 | BANF1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.20e-03 | 4.07e-01 | 0.0216 |
8815 | BANF1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.37e-20 | 6.74e-01 | -0.0811 |
8815 | BANF1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.11e-06 | 2.50e-01 | -0.1088 |
8815 | BANF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.89e-19 | 4.52e-01 | -0.1954 |
8815 | BANF1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.59e-05 | 5.67e-01 | -0.2602 |
8815 | BANF1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.32e-02 | 3.03e-01 | -0.2196 |
8815 | BANF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.70e-13 | 4.95e-01 | -0.1207 |
8815 | BANF1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.78e-11 | 5.19e-01 | -0.1526 |
8815 | BANF1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.69e-24 | 5.20e-01 | -0.1464 |
8815 | BANF1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.55e-09 | 3.53e-01 | -0.1001 |
8815 | BANF1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.94e-30 | 7.75e-01 | -0.059 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070593 | Esophagus | HGIN | chromosome segregation | 71/2587 | 346/18723 | 3.47e-04 | 5.62e-03 | 71 |
GO:004852510 | Esophagus | HGIN | negative regulation of viral process | 25/2587 | 92/18723 | 5.41e-04 | 7.71e-03 | 25 |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:0019079111 | Esophagus | ESCC | viral genome replication | 102/8552 | 131/18723 | 4.31e-14 | 2.19e-12 | 102 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:0050792111 | Esophagus | ESCC | regulation of viral process | 119/8552 | 164/18723 | 2.19e-12 | 9.03e-11 | 119 |
GO:1903900111 | Esophagus | ESCC | regulation of viral life cycle | 106/8552 | 148/18723 | 1.26e-10 | 3.72e-09 | 106 |
GO:0045069110 | Esophagus | ESCC | regulation of viral genome replication | 67/8552 | 85/18723 | 3.81e-10 | 1.04e-08 | 67 |
GO:004852516 | Esophagus | ESCC | negative regulation of viral process | 66/8552 | 92/18723 | 3.49e-07 | 4.88e-06 | 66 |
GO:004507114 | Esophagus | ESCC | negative regulation of viral genome replication | 44/8552 | 56/18723 | 4.84e-07 | 6.50e-06 | 44 |
GO:001603212 | Liver | Cirrhotic | viral process | 203/4634 | 415/18723 | 5.40e-27 | 3.76e-24 | 203 |
GO:001905812 | Liver | Cirrhotic | viral life cycle | 148/4634 | 317/18723 | 1.12e-17 | 1.64e-15 | 148 |
GO:001907912 | Liver | Cirrhotic | viral genome replication | 69/4634 | 131/18723 | 5.77e-12 | 3.98e-10 | 69 |
GO:00507927 | Liver | Cirrhotic | regulation of viral process | 74/4634 | 164/18723 | 9.54e-09 | 3.69e-07 | 74 |
GO:19039007 | Liver | Cirrhotic | regulation of viral life cycle | 64/4634 | 148/18723 | 6.12e-07 | 1.32e-05 | 64 |
GO:004506912 | Liver | Cirrhotic | regulation of viral genome replication | 41/4634 | 85/18723 | 2.28e-06 | 4.19e-05 | 41 |
GO:00096155 | Liver | Cirrhotic | response to virus | 126/4634 | 367/18723 | 2.10e-05 | 2.77e-04 | 126 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BANF1 | SNV | Missense_Mutation | novel | c.118N>C | p.Asp40His | p.D40H | O75531 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
BANF1 | deletion | Frame_Shift_Del | novel | c.261delC | p.Phe88SerfsTer84 | p.F88Sfs*84 | O75531 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
BANF1 | SNV | Missense_Mutation | c.205N>A | p.Ala69Thr | p.A69T | O75531 | protein_coding | deleterious(0.01) | benign(0.382) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BANF1 | SNV | Missense_Mutation | c.65N>A | p.Ser22Asn | p.S22N | O75531 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BANF1 | SNV | Missense_Mutation | rs772391821 | c.235N>A | p.Gly79Arg | p.G79R | O75531 | protein_coding | tolerated(0.54) | benign(0.123) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BANF1 | SNV | Missense_Mutation | c.256N>A | p.Asp86Asn | p.D86N | O75531 | protein_coding | tolerated(0.19) | benign(0.041) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
BANF1 | SNV | Missense_Mutation | novel | c.20N>G | p.His7Arg | p.H7R | O75531 | protein_coding | deleterious(0.03) | probably_damaging(0.95) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BANF1 | SNV | Missense_Mutation | c.45G>T | p.Met15Ile | p.M15I | O75531 | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-44-7669-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | PD | |
BANF1 | SNV | Missense_Mutation | c.124N>A | p.Ala42Thr | p.A42T | O75531 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BANF1 | SNV | Missense_Mutation | novel | c.32T>C | p.Val11Ala | p.V11A | O75531 | protein_coding | deleterious(0.01) | possibly_damaging(0.527) | TCGA-HF-7134-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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