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Gene: ATP5F1E |
Gene summary for ATP5F1E |
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Gene information | Species | Human | Gene symbol | ATP5F1E | Gene ID | 514 |
Gene name | ATP synthase F1 subunit epsilon | |
Gene Alias | ATP5E | |
Cytomap | 20q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P56381 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
514 | ATP5F1E | GSM4909281 | Human | Breast | IDC | 2.59e-20 | 3.75e-01 | 0.21 |
514 | ATP5F1E | GSM4909282 | Human | Breast | IDC | 6.02e-23 | 5.15e-01 | -0.0288 |
514 | ATP5F1E | GSM4909285 | Human | Breast | IDC | 5.53e-35 | 2.69e-01 | 0.21 |
514 | ATP5F1E | GSM4909286 | Human | Breast | IDC | 5.99e-32 | 5.51e-01 | 0.1081 |
514 | ATP5F1E | GSM4909287 | Human | Breast | IDC | 2.39e-31 | 5.99e-01 | 0.2057 |
514 | ATP5F1E | GSM4909289 | Human | Breast | IDC | 1.97e-07 | 5.66e-01 | 0.1064 |
514 | ATP5F1E | GSM4909290 | Human | Breast | IDC | 1.59e-31 | 6.51e-01 | 0.2096 |
514 | ATP5F1E | GSM4909291 | Human | Breast | IDC | 6.17e-30 | 6.76e-01 | 0.1753 |
514 | ATP5F1E | GSM4909293 | Human | Breast | IDC | 7.20e-55 | 7.54e-01 | 0.1581 |
514 | ATP5F1E | GSM4909294 | Human | Breast | IDC | 9.29e-35 | 7.31e-01 | 0.2022 |
514 | ATP5F1E | GSM4909295 | Human | Breast | IDC | 3.16e-09 | 4.75e-01 | 0.0898 |
514 | ATP5F1E | GSM4909296 | Human | Breast | IDC | 1.30e-27 | 6.74e-01 | 0.1524 |
514 | ATP5F1E | GSM4909297 | Human | Breast | IDC | 5.82e-32 | 6.23e-01 | 0.1517 |
514 | ATP5F1E | GSM4909298 | Human | Breast | IDC | 5.11e-49 | 7.58e-01 | 0.1551 |
514 | ATP5F1E | GSM4909299 | Human | Breast | IDC | 5.87e-25 | 5.76e-01 | 0.035 |
514 | ATP5F1E | GSM4909300 | Human | Breast | IDC | 1.43e-13 | 5.15e-01 | 0.0334 |
514 | ATP5F1E | GSM4909301 | Human | Breast | IDC | 4.92e-108 | 9.88e-01 | 0.1577 |
514 | ATP5F1E | GSM4909302 | Human | Breast | IDC | 3.46e-20 | 5.01e-01 | 0.1545 |
514 | ATP5F1E | GSM4909303 | Human | Breast | IDC | 1.44e-14 | 6.74e-01 | 0.0438 |
514 | ATP5F1E | GSM4909304 | Human | Breast | IDC | 9.25e-81 | 8.84e-01 | 0.1636 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001969314 | Breast | IDC | ribose phosphate metabolic process | 58/1434 | 396/18723 | 1.31e-06 | 5.73e-05 | 58 |
GO:000675313 | Breast | IDC | nucleoside phosphate metabolic process | 68/1434 | 497/18723 | 2.01e-06 | 8.23e-05 | 68 |
GO:000911713 | Breast | IDC | nucleotide metabolic process | 67/1434 | 489/18723 | 2.28e-06 | 9.05e-05 | 67 |
GO:000925914 | Breast | IDC | ribonucleotide metabolic process | 56/1434 | 385/18723 | 2.47e-06 | 9.63e-05 | 56 |
GO:000616413 | Breast | IDC | purine nucleotide biosynthetic process | 34/1434 | 191/18723 | 3.11e-06 | 1.15e-04 | 34 |
GO:190129313 | Breast | IDC | nucleoside phosphate biosynthetic process | 41/1434 | 256/18723 | 5.15e-06 | 1.73e-04 | 41 |
GO:000616314 | Breast | IDC | purine nucleotide metabolic process | 56/1434 | 396/18723 | 5.90e-06 | 1.90e-04 | 56 |
GO:007252213 | Breast | IDC | purine-containing compound biosynthetic process | 34/1434 | 200/18723 | 8.79e-06 | 2.50e-04 | 34 |
GO:000916513 | Breast | IDC | nucleotide biosynthetic process | 40/1434 | 254/18723 | 1.01e-05 | 2.81e-04 | 40 |
GO:007252114 | Breast | IDC | purine-containing compound metabolic process | 57/1434 | 416/18723 | 1.28e-05 | 3.31e-04 | 57 |
GO:004603424 | Breast | DCIS | ATP metabolic process | 85/1390 | 277/18723 | 6.79e-31 | 1.92e-27 | 85 |
GO:000611923 | Breast | DCIS | oxidative phosphorylation | 56/1390 | 141/18723 | 3.89e-27 | 7.34e-24 | 56 |
GO:000906023 | Breast | DCIS | aerobic respiration | 61/1390 | 189/18723 | 8.72e-24 | 1.23e-20 | 61 |
GO:000609123 | Breast | DCIS | generation of precursor metabolites and energy | 103/1390 | 490/18723 | 1.46e-22 | 1.65e-19 | 103 |
GO:004533323 | Breast | DCIS | cellular respiration | 62/1390 | 230/18723 | 1.26e-19 | 1.02e-16 | 62 |
GO:001598023 | Breast | DCIS | energy derivation by oxidation of organic compounds | 73/1390 | 318/18723 | 1.56e-18 | 8.01e-16 | 73 |
GO:001598523 | Breast | DCIS | energy coupled proton transport, down electrochemical gradient | 16/1390 | 26/18723 | 2.04e-12 | 4.44e-10 | 16 |
GO:001598623 | Breast | DCIS | ATP synthesis coupled proton transport | 16/1390 | 26/18723 | 2.04e-12 | 4.44e-10 | 16 |
GO:190260022 | Breast | DCIS | proton transmembrane transport | 40/1390 | 157/18723 | 2.77e-12 | 5.80e-10 | 40 |
GO:004277623 | Breast | DCIS | mitochondrial ATP synthesis coupled proton transport | 13/1390 | 19/18723 | 3.51e-11 | 5.22e-09 | 13 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
514 | ATP5F1E | TRANSPORTER | glucocorticoids | 26307125 | ||
514 | ATP5F1E | TRANSPORTER | etanercept | ETANERCEPT | 26307125 | |
514 | ATP5F1E | TRANSPORTER | adalimumab | ADALIMUMAB | 26307125 | |
514 | ATP5F1E | TRANSPORTER | certolizumab pegol | 26307125 | ||
514 | ATP5F1E | TRANSPORTER | methotrexate | METHOTREXATE | 26307125 | |
514 | ATP5F1E | TRANSPORTER | infliximab | INFLIXIMAB | 26307125 |
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