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Gene: ATL1 |
Gene summary for ATL1 |
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Gene information | Species | Human | Gene symbol | ATL1 | Gene ID | 51062 |
Gene name | atlastin GTPase 1 | |
Gene Alias | AD-FSP | |
Cytomap | 14q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A0S2Z5A2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51062 | ATL1 | S015 | Human | Liver | HCC | 7.26e-11 | 6.60e-01 | 0.2375 |
51062 | ATL1 | S016 | Human | Liver | HCC | 6.69e-17 | 7.16e-01 | 0.2243 |
51062 | ATL1 | PTC06 | Human | Thyroid | PTC | 1.10e-05 | 1.43e-01 | 0.2057 |
51062 | ATL1 | ATC13 | Human | Thyroid | ATC | 1.90e-14 | 3.10e-01 | 0.34 |
51062 | ATL1 | ATC2 | Human | Thyroid | ATC | 3.38e-08 | 8.68e-01 | 0.34 |
51062 | ATL1 | ATC5 | Human | Thyroid | ATC | 2.82e-21 | 3.53e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19013614 | Colorectum | FAP | organic cyclic compound catabolic process | 101/2622 | 495/18723 | 4.87e-05 | 9.93e-04 | 101 |
GO:00611572 | Colorectum | FAP | mRNA destabilization | 25/2622 | 84/18723 | 1.43e-04 | 2.24e-03 | 25 |
GO:00507792 | Colorectum | FAP | RNA destabilization | 25/2622 | 88/18723 | 3.19e-04 | 4.12e-03 | 25 |
GO:00339622 | Colorectum | FAP | P-body assembly | 9/2622 | 21/18723 | 1.22e-03 | 1.14e-02 | 9 |
GO:00002882 | Colorectum | FAP | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 16/2622 | 56/18723 | 3.40e-03 | 2.47e-02 | 16 |
GO:00171481 | Colorectum | FAP | negative regulation of translation | 50/2622 | 245/18723 | 3.57e-03 | 2.57e-02 | 50 |
GO:00342491 | Colorectum | FAP | negative regulation of cellular amide metabolic process | 54/2622 | 273/18723 | 5.00e-03 | 3.33e-02 | 54 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:0006402110 | Esophagus | ESCC | mRNA catabolic process | 170/8552 | 232/18723 | 8.70e-18 | 8.00e-16 | 170 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:000095618 | Esophagus | ESCC | nuclear-transcribed mRNA catabolic process | 88/8552 | 112/18723 | 9.41e-13 | 4.14e-11 | 88 |
GO:190331316 | Esophagus | ESCC | positive regulation of mRNA metabolic process | 87/8552 | 118/18723 | 5.10e-10 | 1.32e-08 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATL1 | SNV | Missense_Mutation | rs763902321 | c.58G>A | p.Glu20Lys | p.E20K | Q8WXF7 | protein_coding | tolerated(0.2) | benign(0.023) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ATL1 | SNV | Missense_Mutation | novel | c.590N>A | p.Gly197Asp | p.G197D | Q8WXF7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATL1 | SNV | Missense_Mutation | rs119476046 | c.715N>T | p.Arg239Cys | p.R239C | Q8WXF7 | protein_coding | deleterious(0) | benign(0.286) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATL1 | SNV | Missense_Mutation | novel | c.1608N>G | p.His536Gln | p.H536Q | Q8WXF7 | protein_coding | tolerated_low_confidence(0.55) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATL1 | SNV | Missense_Mutation | c.1309G>A | p.Asp437Asn | p.D437N | Q8WXF7 | protein_coding | tolerated(0.26) | benign(0.006) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ATL1 | SNV | Missense_Mutation | novel | c.1282N>A | p.Leu428Ile | p.L428I | Q8WXF7 | protein_coding | tolerated(0.29) | benign(0.01) | TCGA-VS-A9V5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ATL1 | SNV | Missense_Mutation | c.925N>G | p.Ser309Gly | p.S309G | Q8WXF7 | protein_coding | deleterious(0) | benign(0.025) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATL1 | SNV | Missense_Mutation | c.1047G>T | p.Gln349His | p.Q349H | Q8WXF7 | protein_coding | tolerated(0.08) | possibly_damaging(0.772) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATL1 | SNV | Missense_Mutation | c.283N>A | p.Glu95Lys | p.E95K | Q8WXF7 | protein_coding | tolerated(0.78) | benign(0.017) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATL1 | SNV | Missense_Mutation | c.927C>A | p.Ser309Arg | p.S309R | Q8WXF7 | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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