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Gene: ARPC1B |
Gene summary for ARPC1B |
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Gene information | Species | Human | Gene symbol | ARPC1B | Gene ID | 10095 |
Gene name | actin related protein 2/3 complex subunit 1B | |
Gene Alias | ARC41 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A4D275 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10095 | ARPC1B | GSM4909282 | Human | Breast | IDC | 4.07e-02 | 2.68e-01 | -0.0288 |
10095 | ARPC1B | GSM4909288 | Human | Breast | IDC | 1.87e-03 | 2.42e-02 | 0.0988 |
10095 | ARPC1B | GSM4909290 | Human | Breast | IDC | 3.77e-02 | -2.72e-01 | 0.2096 |
10095 | ARPC1B | GSM4909294 | Human | Breast | IDC | 3.46e-02 | -2.24e-01 | 0.2022 |
10095 | ARPC1B | GSM4909296 | Human | Breast | IDC | 1.47e-04 | 1.78e-01 | 0.1524 |
10095 | ARPC1B | GSM4909297 | Human | Breast | IDC | 8.70e-07 | -1.32e-01 | 0.1517 |
10095 | ARPC1B | GSM4909304 | Human | Breast | IDC | 5.11e-07 | 3.55e-01 | 0.1636 |
10095 | ARPC1B | GSM4909311 | Human | Breast | IDC | 1.12e-19 | -8.78e-02 | 0.1534 |
10095 | ARPC1B | GSM4909312 | Human | Breast | IDC | 1.24e-06 | -1.04e-01 | 0.1552 |
10095 | ARPC1B | GSM4909319 | Human | Breast | IDC | 1.43e-30 | 8.70e-02 | 0.1563 |
10095 | ARPC1B | GSM4909320 | Human | Breast | IDC | 2.22e-03 | -2.12e-01 | 0.1575 |
10095 | ARPC1B | GSM4909321 | Human | Breast | IDC | 3.23e-06 | 2.24e-02 | 0.1559 |
10095 | ARPC1B | brca1 | Human | Breast | Precancer | 3.44e-10 | 5.09e-01 | -0.0338 |
10095 | ARPC1B | brca2 | Human | Breast | Precancer | 7.42e-22 | 5.19e-01 | -0.024 |
10095 | ARPC1B | brca3 | Human | Breast | Precancer | 4.08e-10 | 2.94e-01 | -0.0263 |
10095 | ARPC1B | M2 | Human | Breast | IDC | 9.90e-06 | 3.51e-01 | 0.21 |
10095 | ARPC1B | NCCBC11 | Human | Breast | DCIS | 1.13e-03 | 3.41e-01 | 0.1232 |
10095 | ARPC1B | NCCBC14 | Human | Breast | DCIS | 2.88e-09 | 3.11e-01 | 0.2021 |
10095 | ARPC1B | NCCBC2 | Human | Breast | DCIS | 3.23e-03 | 2.42e-01 | 0.1554 |
10095 | ARPC1B | NCCBC3 | Human | Breast | DCIS | 4.16e-04 | 1.33e-01 | 0.1198 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00323556 | Cervix | CC | response to estradiol | 34/2311 | 141/18723 | 8.19e-05 | 1.11e-03 | 34 |
GO:00080649 | Cervix | CC | regulation of actin polymerization or depolymerization | 42/2311 | 188/18723 | 8.60e-05 | 1.15e-03 | 42 |
GO:00308328 | Cervix | CC | regulation of actin filament length | 42/2311 | 189/18723 | 9.76e-05 | 1.27e-03 | 42 |
GO:003227310 | Cervix | CC | positive regulation of protein polymerization | 33/2311 | 138/18723 | 1.23e-04 | 1.53e-03 | 33 |
GO:00308389 | Cervix | CC | positive regulation of actin filament polymerization | 24/2311 | 99/18723 | 7.93e-04 | 6.99e-03 | 24 |
GO:00343147 | Cervix | CC | Arp2/3 complex-mediated actin nucleation | 11/2311 | 39/18723 | 6.13e-03 | 3.48e-02 | 11 |
GO:000701515 | Cervix | HSIL_HPV | actin filament organization | 43/737 | 442/18723 | 4.77e-08 | 3.59e-06 | 43 |
GO:003295615 | Cervix | HSIL_HPV | regulation of actin cytoskeleton organization | 33/737 | 358/18723 | 5.61e-06 | 2.09e-04 | 33 |
GO:003297015 | Cervix | HSIL_HPV | regulation of actin filament-based process | 35/737 | 397/18723 | 7.87e-06 | 2.81e-04 | 35 |
GO:190290315 | Cervix | HSIL_HPV | regulation of supramolecular fiber organization | 34/737 | 383/18723 | 9.14e-06 | 3.19e-04 | 34 |
GO:003235513 | Cervix | HSIL_HPV | response to estradiol | 18/737 | 141/18723 | 1.09e-05 | 3.69e-04 | 18 |
GO:004325415 | Cervix | HSIL_HPV | regulation of protein-containing complex assembly | 34/737 | 428/18723 | 8.79e-05 | 1.92e-03 | 34 |
GO:011005315 | Cervix | HSIL_HPV | regulation of actin filament organization | 23/737 | 278/18723 | 6.73e-04 | 9.13e-03 | 23 |
GO:003227115 | Cervix | HSIL_HPV | regulation of protein polymerization | 20/737 | 233/18723 | 9.38e-04 | 1.18e-02 | 20 |
GO:003133415 | Cervix | HSIL_HPV | positive regulation of protein-containing complex assembly | 20/737 | 237/18723 | 1.16e-03 | 1.38e-02 | 20 |
GO:003083314 | Cervix | HSIL_HPV | regulation of actin filament polymerization | 16/737 | 172/18723 | 1.28e-03 | 1.48e-02 | 16 |
GO:003004114 | Cervix | HSIL_HPV | actin filament polymerization | 17/737 | 191/18723 | 1.49e-03 | 1.65e-02 | 17 |
GO:190290515 | Cervix | HSIL_HPV | positive regulation of supramolecular fiber organization | 18/737 | 209/18723 | 1.59e-03 | 1.75e-02 | 18 |
GO:005125815 | Cervix | HSIL_HPV | protein polymerization | 23/737 | 297/18723 | 1.63e-03 | 1.77e-02 | 23 |
GO:000815414 | Cervix | HSIL_HPV | actin polymerization or depolymerization | 18/737 | 218/18723 | 2.53e-03 | 2.48e-02 | 18 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513018 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510018 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513019 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510019 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513024 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0510024 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513034 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARPC1B | SNV | Missense_Mutation | c.33N>G | p.Ile11Met | p.I11M | O15143 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
ARPC1B | SNV | Missense_Mutation | c.1072N>A | p.Asp358Asn | p.D358N | O15143 | protein_coding | tolerated(0.15) | probably_damaging(0.953) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ARPC1B | insertion | In_Frame_Ins | novel | c.429_430insTGGGCAGAT | p.Ser143_Thr144insTrpAlaAsp | p.S143_T144insWAD | O15143 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ARPC1B | insertion | Frame_Shift_Ins | novel | c.431_432insAG | p.Val145AlafsTer51 | p.V145Afs*51 | O15143 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ARPC1B | SNV | Missense_Mutation | c.232N>A | p.Val78Met | p.V78M | O15143 | protein_coding | deleterious(0.03) | possibly_damaging(0.751) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARPC1B | SNV | Missense_Mutation | c.932N>T | p.Ser311Phe | p.S311F | O15143 | protein_coding | deleterious(0.01) | possibly_damaging(0.472) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARPC1B | SNV | Missense_Mutation | c.92N>G | p.Glu31Gly | p.E31G | O15143 | protein_coding | deleterious(0.01) | possibly_damaging(0.761) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARPC1B | SNV | Missense_Mutation | novel | c.245N>T | p.Lys82Met | p.K82M | O15143 | protein_coding | deleterious(0.02) | possibly_damaging(0.735) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARPC1B | SNV | Missense_Mutation | novel | c.132G>T | p.Lys44Asn | p.K44N | O15143 | protein_coding | tolerated(0.45) | possibly_damaging(0.794) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | rs369966813 | c.713N>T | p.Ala238Val | p.A238V | O15143 | protein_coding | tolerated(0.51) | benign(0.017) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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