Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/AOC1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/AOC1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/AOC1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/AOC1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425944 | Stomach | GC | response to starvation | 23/1159 | 197/18723 | 2.55e-03 | 2.39e-02 | 23 |
GO:00316685 | Stomach | GC | cellular response to extracellular stimulus | 27/1159 | 246/18723 | 2.79e-03 | 2.55e-02 | 27 |
GO:00092674 | Stomach | GC | cellular response to starvation | 19/1159 | 156/18723 | 3.63e-03 | 3.09e-02 | 19 |
GO:00316694 | Stomach | GC | cellular response to nutrient levels | 24/1159 | 215/18723 | 3.74e-03 | 3.18e-02 | 24 |
GO:00712804 | Stomach | GC | cellular response to copper ion | 6/1159 | 28/18723 | 6.45e-03 | 4.76e-02 | 6 |
GO:001003811 | Stomach | CAG with IM | response to metal ion | 46/1050 | 373/18723 | 4.33e-07 | 2.43e-05 | 46 |
GO:003166711 | Stomach | CAG with IM | response to nutrient levels | 48/1050 | 474/18723 | 5.51e-05 | 1.38e-03 | 48 |
GO:007124111 | Stomach | CAG with IM | cellular response to inorganic substance | 26/1050 | 226/18723 | 4.09e-04 | 6.53e-03 | 26 |
GO:004668811 | Stomach | CAG with IM | response to copper ion | 9/1050 | 42/18723 | 4.41e-04 | 6.87e-03 | 9 |
GO:007124811 | Stomach | CAG with IM | cellular response to metal ion | 23/1050 | 197/18723 | 7.01e-04 | 9.75e-03 | 23 |
GO:007149611 | Stomach | CAG with IM | cellular response to external stimulus | 31/1050 | 320/18723 | 2.20e-03 | 2.24e-02 | 31 |
GO:007128011 | Stomach | CAG with IM | cellular response to copper ion | 6/1050 | 28/18723 | 3.98e-03 | 3.46e-02 | 6 |
GO:003166811 | Stomach | CAG with IM | cellular response to extracellular stimulus | 24/1050 | 246/18723 | 5.99e-03 | 4.63e-02 | 24 |
GO:001003821 | Stomach | CSG | response to metal ion | 45/1034 | 373/18723 | 7.02e-07 | 3.75e-05 | 45 |
GO:003166721 | Stomach | CSG | response to nutrient levels | 49/1034 | 474/18723 | 1.83e-05 | 5.57e-04 | 49 |
GO:007124121 | Stomach | CSG | cellular response to inorganic substance | 26/1034 | 226/18723 | 3.24e-04 | 5.47e-03 | 26 |
GO:00466882 | Stomach | CSG | response to copper ion | 9/1034 | 42/18723 | 3.94e-04 | 6.42e-03 | 9 |
GO:00712482 | Stomach | CSG | cellular response to metal ion | 23/1034 | 197/18723 | 5.68e-04 | 8.32e-03 | 23 |
GO:007149621 | Stomach | CSG | cellular response to external stimulus | 32/1034 | 320/18723 | 8.75e-04 | 1.17e-02 | 32 |
GO:00712802 | Stomach | CSG | cellular response to copper ion | 6/1034 | 28/18723 | 3.69e-03 | 3.27e-02 | 6 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AOC1 | SNV | Missense_Mutation | novel | c.107T>C | p.Leu36Pro | p.L36P | P19801 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AOC1 | SNV | Missense_Mutation | novel | c.1036A>T | p.Ile346Phe | p.I346F | P19801 | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
AOC1 | SNV | Missense_Mutation | novel | c.95T>G | p.Val32Gly | p.V32G | P19801 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
AOC1 | SNV | Missense_Mutation | rs777262841 | c.1487G>A | p.Arg496His | p.R496H | P19801 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-E9-A247-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
AOC1 | SNV | Missense_Mutation | rs766973083 | c.532N>T | p.His178Tyr | p.H178Y | P19801 | protein_coding | tolerated(0.09) | benign(0.187) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
AOC1 | SNV | Missense_Mutation | novel | c.1697C>T | p.Ala566Val | p.A566V | P19801 | protein_coding | deleterious(0.02) | possibly_damaging(0.677) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AOC1 | SNV | Missense_Mutation | novel | c.2251N>C | p.Glu751Gln | p.E751Q | P19801 | protein_coding | tolerated(0.21) | benign(0.277) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AOC1 | SNV | Missense_Mutation | | c.2008N>C | p.Glu670Gln | p.E670Q | P19801 | protein_coding | tolerated(0.14) | benign(0.04) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
AOC1 | SNV | Missense_Mutation | | c.1222G>A | p.Asp408Asn | p.D408N | P19801 | protein_coding | tolerated(0.32) | benign(0.109) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AOC1 | SNV | Missense_Mutation | rs752373263 | c.1141N>A | p.Val381Ile | p.V381I | P19801 | protein_coding | tolerated(0.11) | benign(0.031) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |