Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ANXA11

Gene summary for ANXA11

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ANXA11

Gene ID

311

Gene nameannexin A11
Gene AliasALS23
Cytomap10q22.3
Gene Typeprotein-coding
GO ID

GO:0000910

UniProtAcc

P50995


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
311ANXA11HTA11_3410_2000001011HumanColorectumAD2.00e-124.96e-010.0155
311ANXA11HTA11_2487_2000001011HumanColorectumSER4.94e-311.48e+00-0.1808
311ANXA11HTA11_1938_2000001011HumanColorectumAD1.95e-241.09e+00-0.0811
311ANXA11HTA11_78_2000001011HumanColorectumAD3.41e-188.73e-01-0.1088
311ANXA11HTA11_347_2000001011HumanColorectumAD4.64e-401.13e+00-0.1954
311ANXA11HTA11_411_2000001011HumanColorectumSER1.32e-142.08e+00-0.2602
311ANXA11HTA11_2112_2000001011HumanColorectumSER1.71e-151.49e+00-0.2196
311ANXA11HTA11_3361_2000001011HumanColorectumAD5.71e-169.83e-01-0.1207
311ANXA11HTA11_83_2000001011HumanColorectumSER1.89e-211.10e+00-0.1526
311ANXA11HTA11_696_2000001011HumanColorectumAD1.86e-401.27e+00-0.1464
311ANXA11HTA11_866_2000001011HumanColorectumAD4.82e-248.32e-01-0.1001
311ANXA11HTA11_1391_2000001011HumanColorectumAD2.42e-301.45e+00-0.059
311ANXA11HTA11_2992_2000001011HumanColorectumSER4.81e-131.57e+00-0.1706
311ANXA11HTA11_5212_2000001011HumanColorectumAD3.14e-231.38e+00-0.2061
311ANXA11HTA11_5216_2000001011HumanColorectumSER1.01e-091.08e+00-0.1462
311ANXA11HTA11_546_2000001011HumanColorectumAD6.56e-109.06e-01-0.0842
311ANXA11HTA11_7862_2000001011HumanColorectumAD2.00e-045.97e-01-0.0179
311ANXA11HTA11_866_3004761011HumanColorectumAD5.28e-229.50e-010.096
311ANXA11HTA11_4255_2000001011HumanColorectumSER1.55e-089.82e-010.0446
311ANXA11HTA11_8622_2000001021HumanColorectumSER8.85e-088.41e-010.0528
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00325068ThyroidPTCcytokinetic process25/596839/187233.50e-053.30e-0425
GO:005159219ThyroidPTCresponse to calcium ion65/5968149/187231.67e-039.16e-0365
GO:0000910110ThyroidATCcytokinesis93/6293173/187233.59e-086.67e-0793
GO:003250615ThyroidATCcytokinetic process28/629339/187231.22e-061.57e-0528
GO:0010038210ThyroidATCresponse to metal ion165/6293373/187231.07e-051.05e-04165
GO:005159225ThyroidATCresponse to calcium ion69/6293149/187238.43e-044.62e-0369
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050141ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050142ColorectumSERAmyotrophic lateral sclerosis138/1580364/84659.89e-192.99e-172.17e-17138
hsa050143ColorectumSERAmyotrophic lateral sclerosis138/1580364/84659.89e-192.99e-172.17e-17138
hsa050144ColorectumMSSAmyotrophic lateral sclerosis156/1875364/84651.43e-194.62e-182.83e-18156
hsa050145ColorectumMSSAmyotrophic lateral sclerosis156/1875364/84651.43e-194.62e-182.83e-18156
hsa050146ColorectumMSI-HAmyotrophic lateral sclerosis95/797364/84652.31e-211.50e-191.26e-1995
hsa050147ColorectumMSI-HAmyotrophic lateral sclerosis95/797364/84652.31e-211.50e-191.26e-1995
hsa050148ColorectumFAPAmyotrophic lateral sclerosis91/1404364/84651.84e-052.36e-041.44e-0491
hsa050149ColorectumFAPAmyotrophic lateral sclerosis91/1404364/84651.84e-052.36e-041.44e-0491
hsa0501420EndometriumAEHAmyotrophic lateral sclerosis123/1197364/84652.17e-227.82e-215.72e-21123
hsa05014110EndometriumAEHAmyotrophic lateral sclerosis123/1197364/84652.17e-227.82e-215.72e-21123
hsa0501425EndometriumEECAmyotrophic lateral sclerosis128/1237364/84659.83e-244.04e-223.01e-22128
hsa0501435EndometriumEECAmyotrophic lateral sclerosis128/1237364/84659.83e-244.04e-223.01e-22128
hsa0501430EsophagusHGINAmyotrophic lateral sclerosis140/1383364/84652.13e-251.16e-239.19e-24140
hsa05014113EsophagusHGINAmyotrophic lateral sclerosis140/1383364/84652.13e-251.16e-239.19e-24140
hsa05014210EsophagusESCCAmyotrophic lateral sclerosis266/4205364/84651.31e-202.20e-181.13e-18266
hsa0501438EsophagusESCCAmyotrophic lateral sclerosis266/4205364/84651.31e-202.20e-181.13e-18266
hsa0501414LiverCirrhoticAmyotrophic lateral sclerosis187/2530364/84651.56e-186.50e-174.01e-17187
hsa0501415LiverCirrhoticAmyotrophic lateral sclerosis187/2530364/84651.56e-186.50e-174.01e-17187
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ANXA11FIBProstateBPHACTB,CXCL16,KRT7, etc.1.16e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ANXA11MSCProstateBPHACTB,CXCL16,KRT7, etc.3.40e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ANXA11SNVMissense_Mutationc.1027N>Gp.Gln343Glup.Q343EP50995protein_codingdeleterious(0.02)possibly_damaging(0.704)TCGA-BH-A18F-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
ANXA11SNVMissense_Mutationnovelc.1166N>Ap.Ala389Aspp.A389DP50995protein_codingtolerated(0.06)probably_damaging(0.944)TCGA-E9-A1QZ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ANXA11insertionFrame_Shift_Insnovelc.1366_1367insAGGGGATTACCGGAAGp.Arg456GlnfsTer24p.R456Qfs*24P50995protein_codingTCGA-A8-A06P-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificSD
ANXA11insertionIn_Frame_Insnovelc.1364_1365insACTp.Ile455_Arg456insLeup.I455_R456insLP50995protein_codingTCGA-A8-A06P-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificSD
ANXA11SNVMissense_Mutationrs148593238c.1366C>Tp.Arg456Cysp.R456CP50995protein_codingdeleterious(0)probably_damaging(1)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANXA11SNVMissense_Mutationnovelc.361C>Tp.Pro121Serp.P121SP50995protein_codingtolerated(0.07)benign(0.009)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANXA11SNVMissense_Mutationc.894N>Gp.Ile298Metp.I298MP50995protein_codingdeleterious(0)probably_damaging(0.995)TCGA-C5-A1BQ-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
ANXA11SNVMissense_Mutationnovelc.1489N>Gp.Leu497Valp.L497VP50995protein_codingdeleterious(0)probably_damaging(0.963)TCGA-IR-A3LF-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ANXA11SNVMissense_Mutationc.954N>Gp.Phe318Leup.F318LP50995protein_codingdeleterious(0.04)benign(0.183)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANXA11SNVMissense_Mutationnovelc.343T>Ap.Ser115Thrp.S115TP50995protein_codingtolerated(0.43)benign(0.014)TCGA-AA-3947-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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