Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ANO1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ANO1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ANO1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ANO1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ANO1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016531 | Colorectum | SER | cellular response to peptide | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00342841 | Colorectum | SER | response to monosaccharide | 56/2897 | 225/18723 | 1.52e-04 | 2.98e-03 | 56 |
GO:00507081 | Colorectum | SER | regulation of protein secretion | 63/2897 | 268/18723 | 3.42e-04 | 5.39e-03 | 63 |
GO:00097431 | Colorectum | SER | response to carbohydrate | 60/2897 | 253/18723 | 3.66e-04 | 5.67e-03 | 60 |
GO:00097491 | Colorectum | SER | response to glucose | 52/2897 | 212/18723 | 3.75e-04 | 5.74e-03 | 52 |
GO:00097461 | Colorectum | SER | response to hexose | 53/2897 | 219/18723 | 4.69e-04 | 6.76e-03 | 53 |
GO:00093061 | Colorectum | SER | protein secretion | 79/2897 | 359/18723 | 5.99e-04 | 8.19e-03 | 79 |
GO:00355921 | Colorectum | SER | establishment of protein localization to extracellular region | 79/2897 | 360/18723 | 6.54e-04 | 8.77e-03 | 79 |
GO:00716921 | Colorectum | SER | protein localization to extracellular region | 80/2897 | 368/18723 | 8.13e-04 | 1.01e-02 | 80 |
GO:00346051 | Colorectum | SER | cellular response to heat | 21/2897 | 69/18723 | 1.29e-03 | 1.44e-02 | 21 |
GO:00300731 | Colorectum | SER | insulin secretion | 46/2897 | 195/18723 | 1.86e-03 | 1.90e-02 | 46 |
GO:00507961 | Colorectum | SER | regulation of insulin secretion | 40/2897 | 165/18723 | 2.10e-03 | 2.06e-02 | 40 |
GO:00713331 | Colorectum | SER | cellular response to glucose stimulus | 37/2897 | 151/18723 | 2.48e-03 | 2.33e-02 | 37 |
GO:00425931 | Colorectum | SER | glucose homeostasis | 57/2897 | 258/18723 | 2.92e-03 | 2.59e-02 | 57 |
GO:00158331 | Colorectum | SER | peptide transport | 58/2897 | 264/18723 | 3.08e-03 | 2.70e-02 | 58 |
GO:00713311 | Colorectum | SER | cellular response to hexose stimulus | 37/2897 | 153/18723 | 3.15e-03 | 2.73e-02 | 37 |
GO:00335001 | Colorectum | SER | carbohydrate homeostasis | 57/2897 | 259/18723 | 3.20e-03 | 2.76e-02 | 57 |
GO:00713261 | Colorectum | SER | cellular response to monosaccharide stimulus | 37/2897 | 154/18723 | 3.55e-03 | 3.00e-02 | 37 |
GO:00900871 | Colorectum | SER | regulation of peptide transport | 46/2897 | 202/18723 | 3.86e-03 | 3.18e-02 | 46 |
GO:00016781 | Colorectum | SER | cellular glucose homeostasis | 40/2897 | 172/18723 | 4.61e-03 | 3.65e-02 | 40 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANO1 | SNV | Missense_Mutation | | c.643N>G | p.Gln215Glu | p.Q215E | Q5XXA6 | protein_coding | tolerated(0.94) | benign(0.007) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ANO1 | SNV | Missense_Mutation | | c.1812N>C | p.Glu604Asp | p.E604D | Q5XXA6 | protein_coding | tolerated(0.24) | benign(0.261) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ANO1 | SNV | Missense_Mutation | rs201962504 | c.2632G>A | p.Asp878Asn | p.D878N | Q5XXA6 | protein_coding | deleterious(0.02) | possibly_damaging(0.617) | TCGA-S3-AA12-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
ANO1 | SNV | Missense_Mutation | novel | c.1130N>T | p.Thr377Ile | p.T377I | Q5XXA6 | protein_coding | tolerated(0.18) | possibly_damaging(0.859) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANO1 | SNV | Missense_Mutation | novel | c.2410N>A | p.Val804Met | p.V804M | Q5XXA6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANO1 | SNV | Missense_Mutation | rs770219157 | c.2873N>T | p.Pro958Leu | p.P958L | Q5XXA6 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANO1 | SNV | Missense_Mutation | rs778151682 | c.880N>A | p.Glu294Lys | p.E294K | Q5XXA6 | protein_coding | tolerated(0.07) | benign(0.063) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ANO1 | SNV | Missense_Mutation | | c.1360N>A | p.Pro454Thr | p.P454T | Q5XXA6 | protein_coding | tolerated(0.11) | possibly_damaging(0.898) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ANO1 | SNV | Missense_Mutation | rs373835880 | c.2473N>A | p.Gly825Arg | p.G825R | Q5XXA6 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ANO1 | SNV | Missense_Mutation | rs768459625 | c.2140N>A | p.Glu714Lys | p.E714K | Q5XXA6 | protein_coding | deleterious(0.01) | possibly_damaging(0.745) | TCGA-JX-A5QV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |