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Gene: ALDOC |
Gene summary for ALDOC |
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Gene information | Species | Human | Gene symbol | ALDOC | Gene ID | 230 |
Gene name | aldolase, fructose-bisphosphate C | |
Gene Alias | ALDC | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A024QZ64 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
230 | ALDOC | LZE4T | Human | Esophagus | ESCC | 5.16e-06 | 2.62e-01 | 0.0811 |
230 | ALDOC | LZE8T | Human | Esophagus | ESCC | 9.50e-03 | 1.19e-01 | 0.067 |
230 | ALDOC | LZE24T | Human | Esophagus | ESCC | 1.45e-02 | 1.12e-01 | 0.0596 |
230 | ALDOC | LZE6T | Human | Esophagus | ESCC | 4.63e-02 | 2.44e-01 | 0.0845 |
230 | ALDOC | P4T-E | Human | Esophagus | ESCC | 8.51e-28 | 7.31e-01 | 0.1323 |
230 | ALDOC | P5T-E | Human | Esophagus | ESCC | 4.78e-16 | 3.63e-01 | 0.1327 |
230 | ALDOC | P10T-E | Human | Esophagus | ESCC | 1.96e-14 | 2.73e-01 | 0.116 |
230 | ALDOC | P11T-E | Human | Esophagus | ESCC | 2.63e-04 | 2.43e-01 | 0.1426 |
230 | ALDOC | P12T-E | Human | Esophagus | ESCC | 2.33e-02 | 1.32e-01 | 0.1122 |
230 | ALDOC | P15T-E | Human | Esophagus | ESCC | 6.18e-22 | 5.15e-01 | 0.1149 |
230 | ALDOC | P16T-E | Human | Esophagus | ESCC | 2.76e-12 | 2.53e-01 | 0.1153 |
230 | ALDOC | P17T-E | Human | Esophagus | ESCC | 1.03e-07 | 3.78e-01 | 0.1278 |
230 | ALDOC | P20T-E | Human | Esophagus | ESCC | 8.87e-06 | 1.47e-01 | 0.1124 |
230 | ALDOC | P21T-E | Human | Esophagus | ESCC | 2.85e-25 | 5.78e-01 | 0.1617 |
230 | ALDOC | P24T-E | Human | Esophagus | ESCC | 1.16e-03 | 1.29e-01 | 0.1287 |
230 | ALDOC | P26T-E | Human | Esophagus | ESCC | 9.54e-25 | 5.53e-01 | 0.1276 |
230 | ALDOC | P27T-E | Human | Esophagus | ESCC | 9.16e-13 | 2.71e-01 | 0.1055 |
230 | ALDOC | P28T-E | Human | Esophagus | ESCC | 7.40e-11 | 3.14e-01 | 0.1149 |
230 | ALDOC | P30T-E | Human | Esophagus | ESCC | 1.39e-02 | 1.52e-01 | 0.137 |
230 | ALDOC | P31T-E | Human | Esophagus | ESCC | 2.44e-09 | 1.71e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00193188 | Oral cavity | OSCC | hexose metabolic process | 118/7305 | 237/18723 | 4.53e-04 | 2.73e-03 | 118 |
GO:004603117 | Oral cavity | OSCC | ADP metabolic process | 51/7305 | 90/18723 | 5.08e-04 | 2.97e-03 | 51 |
GO:000609017 | Oral cavity | OSCC | pyruvate metabolic process | 57/7305 | 106/18723 | 1.42e-03 | 6.84e-03 | 57 |
GO:000609618 | Oral cavity | OSCC | glycolytic process | 44/7305 | 81/18723 | 3.66e-03 | 1.51e-02 | 44 |
GO:000675718 | Oral cavity | OSCC | ATP generation from ADP | 44/7305 | 82/18723 | 4.95e-03 | 1.94e-02 | 44 |
GO:001605210 | Oral cavity | OSCC | carbohydrate catabolic process | 76/7305 | 154/18723 | 5.67e-03 | 2.18e-02 | 76 |
GO:000609119 | Oral cavity | LP | generation of precursor metabolites and energy | 214/4623 | 490/18723 | 1.12e-20 | 2.60e-18 | 214 |
GO:0046034110 | Oral cavity | LP | ATP metabolic process | 128/4623 | 277/18723 | 3.95e-15 | 5.38e-13 | 128 |
GO:000675319 | Oral cavity | LP | nucleoside phosphate metabolic process | 161/4623 | 497/18723 | 5.31e-05 | 7.39e-04 | 161 |
GO:0009117110 | Oral cavity | LP | nucleotide metabolic process | 158/4623 | 489/18723 | 7.17e-05 | 9.49e-04 | 158 |
GO:0019693110 | Oral cavity | LP | ribose phosphate metabolic process | 128/4623 | 396/18723 | 3.26e-04 | 3.28e-03 | 128 |
GO:000599613 | Oral cavity | LP | monosaccharide metabolic process | 86/4623 | 257/18723 | 9.13e-04 | 7.79e-03 | 86 |
GO:0072521110 | Oral cavity | LP | purine-containing compound metabolic process | 130/4623 | 416/18723 | 1.30e-03 | 1.05e-02 | 130 |
GO:000913218 | Oral cavity | LP | nucleoside diphosphate metabolic process | 46/4623 | 124/18723 | 1.39e-03 | 1.10e-02 | 46 |
GO:0009259110 | Oral cavity | LP | ribonucleotide metabolic process | 120/4623 | 385/18723 | 2.15e-03 | 1.57e-02 | 120 |
GO:001931813 | Oral cavity | LP | hexose metabolic process | 78/4623 | 237/18723 | 2.55e-03 | 1.80e-02 | 78 |
GO:004693918 | Oral cavity | LP | nucleotide phosphorylation | 38/4623 | 101/18723 | 2.60e-03 | 1.83e-02 | 38 |
GO:0006163110 | Oral cavity | LP | purine nucleotide metabolic process | 122/4623 | 396/18723 | 3.10e-03 | 2.11e-02 | 122 |
GO:0009150110 | Oral cavity | LP | purine ribonucleotide metabolic process | 114/4623 | 368/18723 | 3.41e-03 | 2.28e-02 | 114 |
GO:000918519 | Oral cavity | LP | ribonucleoside diphosphate metabolic process | 39/4623 | 106/18723 | 3.64e-03 | 2.42e-02 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0406629 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0123023 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa000512 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa0001016 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0120033 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa04066113 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0123033 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0005111 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa0001017 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0120041 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0123021 | Liver | HCC | Biosynthesis of amino acids | 53/4020 | 75/8465 | 3.79e-05 | 2.11e-04 | 1.18e-04 | 53 |
hsa0406622 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
hsa0001022 | Liver | HCC | Glycolysis / Gluconeogenesis | 43/4020 | 67/8465 | 4.26e-03 | 1.29e-02 | 7.15e-03 | 43 |
hsa000302 | Liver | HCC | Pentose phosphate pathway | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
hsa0120051 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0123031 | Liver | HCC | Biosynthesis of amino acids | 53/4020 | 75/8465 | 3.79e-05 | 2.11e-04 | 1.18e-04 | 53 |
hsa0406632 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
hsa0001032 | Liver | HCC | Glycolysis / Gluconeogenesis | 43/4020 | 67/8465 | 4.26e-03 | 1.29e-02 | 7.15e-03 | 43 |
hsa000303 | Liver | HCC | Pentose phosphate pathway | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDOC | SNV | Missense_Mutation | c.65N>A | p.Arg22Gln | p.R22Q | P09972 | protein_coding | tolerated(0.33) | benign(0.03) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALDOC | SNV | Missense_Mutation | c.626T>C | p.Val209Ala | p.V209A | P09972 | protein_coding | deleterious(0.02) | probably_damaging(0.924) | TCGA-D8-A1JT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ALDOC | SNV | Missense_Mutation | novel | c.719N>A | p.Cys240Tyr | p.C240Y | P09972 | protein_coding | tolerated(0.06) | possibly_damaging(0.472) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ALDOC | SNV | Missense_Mutation | rs762828594 | c.992N>A | p.Arg331Gln | p.R331Q | P09972 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ALDOC | SNV | Missense_Mutation | rs749373286 | c.589N>T | p.His197Tyr | p.H197Y | P09972 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ALDOC | SNV | Missense_Mutation | c.7N>G | p.His3Asp | p.H3D | P09972 | protein_coding | deleterious(0.05) | benign(0.074) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ALDOC | SNV | Missense_Mutation | rs747367976 | c.517C>T | p.Arg173Cys | p.R173C | P09972 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ALDOC | SNV | Missense_Mutation | rs775893117 | c.98C>T | p.Ala33Val | p.A33V | P09972 | protein_coding | deleterious(0.04) | probably_damaging(0.919) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ALDOC | SNV | Missense_Mutation | rs765845189 | c.776N>A | p.Arg259His | p.R259H | P09972 | protein_coding | deleterious(0.02) | benign(0.415) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ALDOC | SNV | Missense_Mutation | rs145665688 | c.773N>A | p.Arg258His | p.R258H | P09972 | protein_coding | tolerated(0.13) | benign(0.211) | TCGA-AG-A011-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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