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Gene: ALDH2 |
Gene summary for ALDH2 |
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Gene information | Species | Human | Gene symbol | ALDH2 | Gene ID | 217 |
Gene name | aldehyde dehydrogenase 2 family member | |
Gene Alias | ALDH-E2 | |
Cytomap | 12q24.12 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P05091 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
217 | ALDH2 | CA_HPV_3 | Human | Cervix | CC | 6.07e-07 | 2.02e-01 | 0.0414 |
217 | ALDH2 | N_HPV_2 | Human | Cervix | N_HPV | 7.44e-03 | 1.98e-01 | -0.0131 |
217 | ALDH2 | CCI_1 | Human | Cervix | CC | 9.68e-08 | -5.53e-01 | 0.528 |
217 | ALDH2 | CCII_1 | Human | Cervix | CC | 4.91e-10 | -5.19e-01 | 0.3249 |
217 | ALDH2 | sample3 | Human | Cervix | CC | 4.44e-05 | -2.64e-01 | 0.1387 |
217 | ALDH2 | L1 | Human | Cervix | CC | 2.24e-05 | -3.60e-01 | 0.0802 |
217 | ALDH2 | T1 | Human | Cervix | CC | 9.74e-05 | -3.49e-01 | 0.0918 |
217 | ALDH2 | T3 | Human | Cervix | CC | 2.86e-02 | -2.30e-01 | 0.1389 |
217 | ALDH2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.97e-32 | 9.19e-01 | 0.0155 |
217 | ALDH2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.89e-15 | 9.41e-01 | -0.1808 |
217 | ALDH2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.31e-04 | 7.89e-01 | 0.0216 |
217 | ALDH2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.28e-28 | 1.55e+00 | -0.0811 |
217 | ALDH2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.22e-28 | 1.35e+00 | -0.1088 |
217 | ALDH2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.20e-42 | 1.40e+00 | -0.1954 |
217 | ALDH2 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.76e-08 | 1.24e+00 | -0.2602 |
217 | ALDH2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.70e-05 | 1.30e+00 | -0.2196 |
217 | ALDH2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.99e-11 | 9.66e-01 | -0.1207 |
217 | ALDH2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.16e-20 | 1.31e+00 | -0.1526 |
217 | ALDH2 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.35e-32 | 1.12e+00 | -0.1464 |
217 | ALDH2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.71e-26 | 9.08e-01 | -0.1001 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002290026 | Skin | cSCC | electron transport chain | 104/4864 | 175/18723 | 7.28e-21 | 1.23e-18 | 104 |
GO:0006091112 | Thyroid | PTC | generation of precursor metabolites and energy | 252/5968 | 490/18723 | 8.24e-20 | 1.13e-17 | 252 |
GO:0022900111 | Thyroid | PTC | electron transport chain | 104/5968 | 175/18723 | 4.68e-14 | 2.79e-12 | 104 |
GO:000609134 | Thyroid | ATC | generation of precursor metabolites and energy | 256/6293 | 490/18723 | 6.55e-18 | 7.69e-16 | 256 |
GO:002290034 | Thyroid | ATC | electron transport chain | 106/6293 | 175/18723 | 2.20e-13 | 1.06e-11 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa00280 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa00330 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa00310 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa00071 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa00561 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa002801 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa003301 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa003101 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa000711 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa005611 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa006202 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000102 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa003302 | Colorectum | SER | Arginine and proline metabolism | 17/1580 | 50/8465 | 7.12e-03 | 3.77e-02 | 2.74e-02 | 17 |
hsa000712 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa006203 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000103 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDH2 | SNV | Missense_Mutation | rs757893333 | c.1394N>T | p.Ala465Val | p.A465V | P05091 | protein_coding | tolerated(0.09) | benign(0.312) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ALDH2 | insertion | In_Frame_Ins | novel | c.773_774insCCC | p.Val258_Ala259insPro | p.V258_A259insP | P05091 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
ALDH2 | insertion | Frame_Shift_Ins | novel | c.845_846insTCTGAGAAGG | p.Thr283LeufsTer54 | p.T283Lfs*54 | P05091 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
ALDH2 | SNV | Missense_Mutation | novel | c.238N>T | p.Val80Leu | p.V80L | P05091 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ALDH2 | SNV | Missense_Mutation | novel | c.127N>G | p.Asn43Asp | p.N43D | P05091 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ALDH2 | SNV | Missense_Mutation | c.988N>A | p.Asp330Asn | p.D330N | P05091 | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ALDH2 | SNV | Missense_Mutation | c.571A>G | p.Met191Val | p.M191V | P05091 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ALDH2 | SNV | Missense_Mutation | c.740N>T | p.Ala247Val | p.A247V | P05091 | protein_coding | deleterious(0.02) | possibly_damaging(0.453) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ALDH2 | SNV | Missense_Mutation | c.414N>G | p.Asp138Glu | p.D138E | P05091 | protein_coding | tolerated(0.17) | possibly_damaging(0.632) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALDH2 | SNV | Missense_Mutation | rs372769067 | c.1145C>T | p.Ala382Val | p.A382V | P05091 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | ANS-6637 | |||
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | inhibitor | CHEMBL964 | DISULFIRAM | |
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | DISULFIRAM | DISULFIRAM | ||
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | inhibitor | 178103501 | PRUNETIN | |
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | acetaldehyde | ACETALDEHYDE | 31002879 | |
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | heroin | DIACETYLMORPHINE | 21723677 | |
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | ALD-401 | |||
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | DISULFIRAM | DISULFIRAM | ||
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | FP-045 | |||
217 | ALDH2 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | ETHANOL | ALCOHOL | 8986223 |
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