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Gene: ABCE1 |
Gene summary for ABCE1 |
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Gene information | Species | Human | Gene symbol | ABCE1 | Gene ID | 6059 |
Gene name | ATP binding cassette subfamily E member 1 | |
Gene Alias | ABC38 | |
Cytomap | 4q31.21 | |
Gene Type | protein-coding | GO ID | GO:0000054 | UniProtAcc | P61221 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6059 | ABCE1 | LZE2T | Human | Esophagus | ESCC | 6.48e-05 | 4.87e-01 | 0.082 |
6059 | ABCE1 | LZE4T | Human | Esophagus | ESCC | 2.34e-18 | 5.01e-01 | 0.0811 |
6059 | ABCE1 | LZE5T | Human | Esophagus | ESCC | 6.27e-03 | 5.92e-01 | 0.0514 |
6059 | ABCE1 | LZE7T | Human | Esophagus | ESCC | 4.34e-02 | 1.69e-01 | 0.0667 |
6059 | ABCE1 | LZE8T | Human | Esophagus | ESCC | 4.73e-10 | 2.01e-01 | 0.067 |
6059 | ABCE1 | LZE20T | Human | Esophagus | ESCC | 2.37e-04 | 3.19e-02 | 0.0662 |
6059 | ABCE1 | LZE22D1 | Human | Esophagus | HGIN | 1.08e-02 | 1.64e-02 | 0.0595 |
6059 | ABCE1 | LZE22T | Human | Esophagus | ESCC | 4.45e-02 | 1.43e-01 | 0.068 |
6059 | ABCE1 | LZE24T | Human | Esophagus | ESCC | 2.60e-11 | 1.52e-01 | 0.0596 |
6059 | ABCE1 | LZE21T | Human | Esophagus | ESCC | 4.72e-04 | 1.11e-01 | 0.0655 |
6059 | ABCE1 | LZE6T | Human | Esophagus | ESCC | 2.38e-06 | 3.51e-01 | 0.0845 |
6059 | ABCE1 | P1T-E | Human | Esophagus | ESCC | 2.32e-05 | 3.14e-01 | 0.0875 |
6059 | ABCE1 | P2T-E | Human | Esophagus | ESCC | 3.97e-43 | 8.92e-01 | 0.1177 |
6059 | ABCE1 | P4T-E | Human | Esophagus | ESCC | 4.70e-34 | 7.57e-01 | 0.1323 |
6059 | ABCE1 | P5T-E | Human | Esophagus | ESCC | 4.11e-11 | 3.40e-01 | 0.1327 |
6059 | ABCE1 | P8T-E | Human | Esophagus | ESCC | 1.40e-18 | 3.15e-01 | 0.0889 |
6059 | ABCE1 | P9T-E | Human | Esophagus | ESCC | 2.78e-17 | 3.40e-01 | 0.1131 |
6059 | ABCE1 | P10T-E | Human | Esophagus | ESCC | 3.46e-29 | 5.44e-01 | 0.116 |
6059 | ABCE1 | P11T-E | Human | Esophagus | ESCC | 3.39e-20 | 7.18e-01 | 0.1426 |
6059 | ABCE1 | P12T-E | Human | Esophagus | ESCC | 2.53e-45 | 1.06e+00 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641318 | Oral cavity | OSCC | translational initiation | 96/7305 | 118/18723 | 4.02e-21 | 7.06e-19 | 96 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
GO:005116817 | Oral cavity | OSCC | nuclear export | 112/7305 | 154/18723 | 1.70e-17 | 1.56e-15 | 112 |
GO:00711664 | Oral cavity | OSCC | ribonucleoprotein complex localization | 59/7305 | 77/18723 | 1.91e-11 | 6.57e-10 | 59 |
GO:003298410 | Oral cavity | OSCC | protein-containing complex disassembly | 136/7305 | 224/18723 | 3.42e-11 | 1.13e-09 | 136 |
GO:00714264 | Oral cavity | OSCC | ribonucleoprotein complex export from nucleus | 58/7305 | 76/18723 | 3.78e-11 | 1.23e-09 | 58 |
GO:00315034 | Oral cavity | OSCC | protein-containing complex localization | 123/7305 | 220/18723 | 2.54e-07 | 4.00e-06 | 123 |
GO:00320697 | Oral cavity | OSCC | regulation of nuclease activity | 20/7305 | 22/18723 | 6.02e-07 | 8.64e-06 | 20 |
GO:005134618 | Oral cavity | OSCC | negative regulation of hydrolase activity | 182/7305 | 379/18723 | 1.98e-04 | 1.32e-03 | 182 |
GO:00000546 | Oral cavity | OSCC | ribosomal subunit export from nucleus | 12/7305 | 14/18723 | 4.62e-04 | 2.76e-03 | 12 |
GO:00337506 | Oral cavity | OSCC | ribosome localization | 12/7305 | 14/18723 | 4.62e-04 | 2.76e-03 | 12 |
GO:00714283 | Oral cavity | OSCC | rRNA-containing ribonucleoprotein complex export from nucleus | 12/7305 | 15/18723 | 1.49e-03 | 7.13e-03 | 12 |
GO:0006415 | Oral cavity | OSCC | translational termination | 13/7305 | 18/18723 | 4.45e-03 | 1.79e-02 | 13 |
GO:00436244 | Oral cavity | OSCC | cellular protein complex disassembly | 68/7305 | 136/18723 | 5.84e-03 | 2.24e-02 | 68 |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
GO:000641729 | Skin | cSCC | regulation of translation | 226/4864 | 468/18723 | 8.78e-26 | 2.62e-23 | 226 |
GO:000691324 | Skin | cSCC | nucleocytoplasmic transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:005116924 | Skin | cSCC | nuclear transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCE1 | SNV | Missense_Mutation | c.1795N>T | p.Asp599Tyr | p.D599Y | P61221 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ABCE1 | SNV | Missense_Mutation | novel | c.1586N>T | p.Ala529Val | p.A529V | P61221 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-B6-A402-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PD |
ABCE1 | SNV | Missense_Mutation | novel | c.81N>C | p.Lys27Asn | p.K27N | P61221 | protein_coding | tolerated(0.15) | benign(0.151) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABCE1 | SNV | Missense_Mutation | c.1462C>G | p.Pro488Ala | p.P488A | P61221 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABCE1 | SNV | Missense_Mutation | c.869N>G | p.Tyr290Cys | p.Y290C | P61221 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EW-A1J3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ABCE1 | SNV | Missense_Mutation | novel | c.451G>A | p.Glu151Lys | p.E151K | P61221 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ABCE1 | SNV | Missense_Mutation | c.1524A>G | p.Ile508Met | p.I508M | P61221 | protein_coding | deleterious(0.05) | possibly_damaging(0.903) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ABCE1 | SNV | Missense_Mutation | rs550948053 | c.1273C>T | p.Arg425Cys | p.R425C | P61221 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ABCE1 | SNV | Missense_Mutation | c.347A>T | p.Lys116Met | p.K116M | P61221 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABCE1 | SNV | Missense_Mutation | c.533A>G | p.Lys178Arg | p.K178R | P61221 | protein_coding | tolerated(0.35) | benign(0.03) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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