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Gene: PPARGC1A |
Gene summary for PPARGC1A |
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Gene information | Species | Human | Gene symbol | PPARGC1A | Gene ID | 10891 |
Gene name | PPARG coactivator 1 alpha | |
Gene Alias | LEM6 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000002 | UniProtAcc | Q9UBK2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10891 | PPARGC1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.31e-19 | -6.52e-01 | 0.0155 |
10891 | PPARGC1A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.04e-02 | -4.65e-01 | -0.1207 |
10891 | PPARGC1A | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-13 | -5.83e-01 | 0.096 |
10891 | PPARGC1A | HTA11_9408_2000001011 | Human | Colorectum | AD | 5.05e-04 | -8.05e-01 | 0.0451 |
10891 | PPARGC1A | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.25e-04 | -7.11e-01 | 0.0528 |
10891 | PPARGC1A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.06e-10 | -6.81e-01 | 0.0338 |
10891 | PPARGC1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.89e-19 | -5.75e-01 | 0.0674 |
10891 | PPARGC1A | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.01e-03 | -6.23e-01 | 0.0112 |
10891 | PPARGC1A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.35e-04 | -4.07e-01 | 0.294 |
10891 | PPARGC1A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.52e-03 | -4.76e-01 | 0.281 |
10891 | PPARGC1A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.91e-14 | -5.37e-01 | 0.3859 |
10891 | PPARGC1A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.07e-08 | -6.95e-01 | 0.2585 |
10891 | PPARGC1A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.63e-37 | -7.87e-01 | 0.3005 |
10891 | PPARGC1A | F007 | Human | Colorectum | FAP | 2.81e-05 | -3.94e-01 | 0.1176 |
10891 | PPARGC1A | A001-C-207 | Human | Colorectum | FAP | 3.90e-09 | -4.80e-01 | 0.1278 |
10891 | PPARGC1A | A015-C-203 | Human | Colorectum | FAP | 1.22e-28 | -6.23e-01 | -0.1294 |
10891 | PPARGC1A | A015-C-204 | Human | Colorectum | FAP | 1.29e-08 | -4.66e-01 | -0.0228 |
10891 | PPARGC1A | A014-C-040 | Human | Colorectum | FAP | 1.91e-05 | -5.20e-01 | -0.1184 |
10891 | PPARGC1A | A002-C-201 | Human | Colorectum | FAP | 3.93e-17 | -4.95e-01 | 0.0324 |
10891 | PPARGC1A | A002-C-203 | Human | Colorectum | FAP | 1.06e-07 | -4.13e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000609012 | Liver | Cirrhotic | pyruvate metabolic process | 50/4634 | 106/18723 | 4.39e-07 | 1.02e-05 | 50 |
GO:00435431 | Liver | Cirrhotic | protein acylation | 95/4634 | 243/18723 | 4.73e-07 | 1.07e-05 | 95 |
GO:004346712 | Liver | Cirrhotic | regulation of generation of precursor metabolites and energy | 58/4634 | 130/18723 | 5.81e-07 | 1.28e-05 | 58 |
GO:001605212 | Liver | Cirrhotic | carbohydrate catabolic process | 66/4634 | 154/18723 | 6.10e-07 | 1.32e-05 | 66 |
GO:000762312 | Liver | Cirrhotic | circadian rhythm | 84/4634 | 210/18723 | 7.04e-07 | 1.50e-05 | 84 |
GO:000616512 | Liver | Cirrhotic | nucleoside diphosphate phosphorylation | 47/4634 | 99/18723 | 7.63e-07 | 1.61e-05 | 47 |
GO:004593612 | Liver | Cirrhotic | negative regulation of phosphate metabolic process | 154/4634 | 441/18723 | 8.78e-07 | 1.83e-05 | 154 |
GO:001056312 | Liver | Cirrhotic | negative regulation of phosphorus metabolic process | 154/4634 | 442/18723 | 1.02e-06 | 2.11e-05 | 154 |
GO:00108216 | Liver | Cirrhotic | regulation of mitochondrion organization | 62/4634 | 144/18723 | 1.09e-06 | 2.22e-05 | 62 |
GO:00182051 | Liver | Cirrhotic | peptidyl-lysine modification | 134/4634 | 376/18723 | 1.29e-06 | 2.59e-05 | 134 |
GO:000974612 | Liver | Cirrhotic | response to hexose | 86/4634 | 219/18723 | 1.30e-06 | 2.59e-05 | 86 |
GO:00704827 | Liver | Cirrhotic | response to oxygen levels | 125/4634 | 347/18723 | 1.55e-06 | 3.02e-05 | 125 |
GO:001921611 | Liver | Cirrhotic | regulation of lipid metabolic process | 119/4634 | 331/18723 | 3.05e-06 | 5.39e-05 | 119 |
GO:004232612 | Liver | Cirrhotic | negative regulation of phosphorylation | 135/4634 | 385/18723 | 3.17e-06 | 5.58e-05 | 135 |
GO:00106397 | Liver | Cirrhotic | negative regulation of organelle organization | 124/4634 | 348/18723 | 3.20e-06 | 5.60e-05 | 124 |
GO:007155911 | Liver | Cirrhotic | response to transforming growth factor beta | 96/4634 | 256/18723 | 3.55e-06 | 6.09e-05 | 96 |
GO:000609612 | Liver | Cirrhotic | glycolytic process | 39/4634 | 81/18723 | 4.22e-06 | 7.06e-05 | 39 |
GO:00097497 | Liver | Cirrhotic | response to glucose | 82/4634 | 212/18723 | 4.54e-06 | 7.51e-05 | 82 |
GO:00329221 | Liver | Cirrhotic | circadian regulation of gene expression | 34/4634 | 68/18723 | 6.04e-06 | 9.74e-05 | 34 |
GO:000675712 | Liver | Cirrhotic | ATP generation from ADP | 39/4634 | 82/18723 | 6.14e-06 | 9.82e-05 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa042111 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa050163 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa049223 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa050164 | Colorectum | MSS | Huntington disease | 141/1875 | 306/8465 | 2.90e-21 | 1.62e-19 | 9.92e-20 | 141 |
hsa047144 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
hsa049224 | Colorectum | MSS | Glucagon signaling pathway | 39/1875 | 107/8465 | 5.00e-04 | 3.45e-03 | 2.11e-03 | 39 |
hsa042112 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PPARGC1A | ICAF | Cervix | HSIL_HPV | SEMA3B,SLC7A2,KIAA0408, etc. | 2.52e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPARGC1A | SNV | Missense_Mutation | rs749421285 | c.1063T>A | p.Tyr355Asn | p.Y355N | Q9UBK2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD |
PPARGC1A | SNV | Missense_Mutation | rs139240743 | c.1841G>A | p.Arg614Gln | p.R614Q | Q9UBK2 | protein_coding | tolerated(0.06) | benign(0.018) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPARGC1A | SNV | Missense_Mutation | c.695N>T | p.Ser232Ile | p.S232I | Q9UBK2 | protein_coding | deleterious(0.03) | possibly_damaging(0.491) | TCGA-B6-A0RL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPARGC1A | SNV | Missense_Mutation | novel | c.202N>A | p.Gln68Lys | p.Q68K | Q9UBK2 | protein_coding | deleterious(0) | benign(0.22) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPARGC1A | SNV | Missense_Mutation | c.1817G>A | p.Ser606Asn | p.S606N | Q9UBK2 | protein_coding | tolerated_low_confidence(0.26) | benign(0.007) | TCGA-BH-A0E1-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PPARGC1A | SNV | Missense_Mutation | c.1978N>C | p.Glu660Gln | p.E660Q | Q9UBK2 | protein_coding | tolerated(0.08) | benign(0.153) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PPARGC1A | SNV | Missense_Mutation | novel | c.1511G>A | p.Gly504Glu | p.G504E | Q9UBK2 | protein_coding | tolerated_low_confidence(0.11) | probably_damaging(0.999) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PPARGC1A | SNV | Missense_Mutation | novel | c.2271N>A | p.Phe757Leu | p.F757L | Q9UBK2 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PPARGC1A | SNV | Missense_Mutation | c.664N>T | p.His222Tyr | p.H222Y | Q9UBK2 | protein_coding | deleterious(0.02) | benign(0.388) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PPARGC1A | SNV | Missense_Mutation | rs143103266 | c.1951N>T | p.Arg651Cys | p.R651C | Q9UBK2 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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