Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00712193 | Stomach | CAG | cellular response to molecule of bacterial origin | 15/552 | 221/18723 | 2.41e-03 | 2.61e-02 | 15 |
GO:00507143 | Stomach | CAG | positive regulation of protein secretion | 11/552 | 137/18723 | 2.47e-03 | 2.62e-02 | 11 |
GO:00100421 | Stomach | CAG | response to manganese ion | 4/552 | 20/18723 | 2.49e-03 | 2.62e-02 | 4 |
GO:00712163 | Stomach | CAG | cellular response to biotic stimulus | 16/552 | 246/18723 | 2.70e-03 | 2.77e-02 | 16 |
GO:000989631 | Stomach | CAG | positive regulation of catabolic process | 26/552 | 492/18723 | 3.14e-03 | 3.08e-02 | 26 |
GO:003133131 | Stomach | CAG | positive regulation of cellular catabolic process | 23/552 | 427/18723 | 4.22e-03 | 3.82e-02 | 23 |
GO:00510475 | Stomach | CAG | positive regulation of secretion | 18/552 | 310/18723 | 5.06e-03 | 4.31e-02 | 18 |
GO:000930631 | Stomach | CAG | protein secretion | 20/552 | 359/18723 | 5.11e-03 | 4.33e-02 | 20 |
GO:003559231 | Stomach | CAG | establishment of protein localization to extracellular region | 20/552 | 360/18723 | 5.26e-03 | 4.43e-02 | 20 |
GO:001063431 | Stomach | CAG | positive regulation of epithelial cell migration | 12/552 | 176/18723 | 6.08e-03 | 4.87e-02 | 12 |
GO:005070831 | Stomach | CAG | regulation of protein secretion | 16/552 | 268/18723 | 6.15e-03 | 4.88e-02 | 16 |
GO:00106326 | Stomach | CAG | regulation of epithelial cell migration | 17/552 | 292/18723 | 6.18e-03 | 4.89e-02 | 17 |
GO:00336746 | Stomach | CAG | positive regulation of kinase activity | 24/552 | 467/18723 | 6.24e-03 | 4.93e-02 | 24 |
GO:000697941 | Stomach | WIM | response to oxidative stress | 30/426 | 446/18723 | 1.34e-07 | 1.30e-05 | 30 |
GO:000030241 | Stomach | WIM | response to reactive oxygen species | 20/426 | 222/18723 | 1.88e-07 | 1.69e-05 | 20 |
GO:004254241 | Stomach | WIM | response to hydrogen peroxide | 16/426 | 146/18723 | 2.27e-07 | 1.96e-05 | 16 |
GO:00022374 | Stomach | WIM | response to molecule of bacterial origin | 25/426 | 363/18723 | 9.89e-07 | 7.03e-05 | 25 |
GO:004578541 | Stomach | WIM | positive regulation of cell adhesion | 26/426 | 437/18723 | 8.76e-06 | 4.09e-04 | 26 |
GO:00324964 | Stomach | WIM | response to lipopolysaccharide | 22/426 | 343/18723 | 1.37e-05 | 6.02e-04 | 22 |
GO:001003841 | Stomach | WIM | response to metal ion | 23/426 | 373/18723 | 1.64e-05 | 6.85e-04 | 23 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAM9 | SNV | Missense_Mutation | | c.1158N>A | p.Ser386Arg | p.S386R | Q13443 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ADAM9 | SNV | Missense_Mutation | novel | c.1933N>C | p.Asp645His | p.D645H | Q13443 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E2-A9RU-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD |
ADAM9 | SNV | Missense_Mutation | novel | c.1439N>T | p.Cys480Phe | p.C480F | Q13443 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EW-A1PC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ADAM9 | deletion | Frame_Shift_Del | novel | c.1942delN | p.Lys649SerfsTer43 | p.K649Sfs*43 | Q13443 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ADAM9 | deletion | Frame_Shift_Del | novel | c.2429delC | p.Pro810LeufsTer26 | p.P810Lfs*26 | Q13443 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
ADAM9 | SNV | Missense_Mutation | novel | c.1825N>C | p.Ser609Pro | p.S609P | Q13443 | protein_coding | deleterious(0.01) | benign(0.405) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ADAM9 | SNV | Missense_Mutation | | c.2264N>T | p.Arg755Leu | p.R755L | Q13443 | protein_coding | tolerated(0.15) | benign(0.018) | TCGA-EA-A1QS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ADAM9 | SNV | Missense_Mutation | | c.1028C>T | p.Ser343Phe | p.S343F | Q13443 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ADAM9 | SNV | Missense_Mutation | | c.475N>C | p.Glu159Gln | p.E159Q | Q13443 | protein_coding | tolerated(0.26) | possibly_damaging(0.629) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ADAM9 | SNV | Missense_Mutation | | c.605N>C | p.Arg202Pro | p.R202P | Q13443 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |