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Gene: PTGES3 |
Gene summary for PTGES3 |
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Gene information | Species | Human | Gene symbol | PTGES3 | Gene ID | 10728 |
Gene name | prostaglandin E synthase 3 | |
Gene Alias | P23 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q15185 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10728 | PTGES3 | GSM4909285 | Human | Breast | IDC | 3.31e-13 | 4.66e-01 | 0.21 |
10728 | PTGES3 | GSM4909286 | Human | Breast | IDC | 1.09e-07 | -1.84e-01 | 0.1081 |
10728 | PTGES3 | GSM4909288 | Human | Breast | IDC | 1.15e-03 | 4.81e-02 | 0.0988 |
10728 | PTGES3 | GSM4909293 | Human | Breast | IDC | 8.33e-06 | 2.24e-01 | 0.1581 |
10728 | PTGES3 | GSM4909294 | Human | Breast | IDC | 3.17e-22 | 2.98e-01 | 0.2022 |
10728 | PTGES3 | GSM4909296 | Human | Breast | IDC | 2.32e-23 | -4.90e-01 | 0.1524 |
10728 | PTGES3 | GSM4909297 | Human | Breast | IDC | 5.46e-23 | 1.75e-02 | 0.1517 |
10728 | PTGES3 | GSM4909301 | Human | Breast | IDC | 2.23e-02 | -2.27e-01 | 0.1577 |
10728 | PTGES3 | GSM4909302 | Human | Breast | IDC | 4.52e-04 | -2.84e-01 | 0.1545 |
10728 | PTGES3 | GSM4909311 | Human | Breast | IDC | 1.24e-52 | -6.49e-01 | 0.1534 |
10728 | PTGES3 | GSM4909312 | Human | Breast | IDC | 3.05e-14 | -2.09e-01 | 0.1552 |
10728 | PTGES3 | GSM4909313 | Human | Breast | IDC | 2.55e-07 | -2.76e-01 | 0.0391 |
10728 | PTGES3 | GSM4909315 | Human | Breast | IDC | 2.19e-28 | 5.13e-01 | 0.21 |
10728 | PTGES3 | GSM4909316 | Human | Breast | IDC | 6.81e-03 | 8.40e-02 | 0.21 |
10728 | PTGES3 | GSM4909317 | Human | Breast | IDC | 2.79e-05 | 3.30e-01 | 0.1355 |
10728 | PTGES3 | GSM4909318 | Human | Breast | IDC | 4.14e-09 | 4.08e-01 | 0.2031 |
10728 | PTGES3 | GSM4909319 | Human | Breast | IDC | 1.12e-53 | -5.35e-01 | 0.1563 |
10728 | PTGES3 | GSM4909320 | Human | Breast | IDC | 4.61e-09 | -5.48e-01 | 0.1575 |
10728 | PTGES3 | GSM4909321 | Human | Breast | IDC | 3.61e-36 | 3.98e-01 | 0.1559 |
10728 | PTGES3 | brca1 | Human | Breast | Precancer | 3.64e-05 | 2.84e-01 | -0.0338 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051973110 | Skin | cSCC | positive regulation of telomerase activity | 19/4864 | 34/18723 | 2.03e-04 | 1.69e-03 | 19 |
GO:004292111 | Skin | cSCC | glucocorticoid receptor signaling pathway | 10/4864 | 14/18723 | 4.77e-04 | 3.60e-03 | 10 |
GO:00319583 | Skin | cSCC | corticosteroid receptor signaling pathway | 10/4864 | 15/18723 | 1.10e-03 | 7.24e-03 | 10 |
GO:003032417 | Skin | cSCC | lung development | 60/4864 | 177/18723 | 1.14e-02 | 4.97e-02 | 60 |
GO:00060916 | Stomach | GC | generation of precursor metabolites and energy | 88/1159 | 490/18723 | 6.82e-20 | 9.27e-17 | 88 |
GO:00159806 | Stomach | GC | energy derivation by oxidation of organic compounds | 64/1159 | 318/18723 | 2.79e-17 | 2.16e-14 | 64 |
GO:00064576 | Stomach | GC | protein folding | 42/1159 | 212/18723 | 1.46e-11 | 3.31e-09 | 42 |
GO:00066315 | Stomach | GC | fatty acid metabolic process | 55/1159 | 390/18723 | 8.63e-09 | 8.38e-07 | 55 |
GO:00064586 | Stomach | GC | 'de novo' protein folding | 15/1159 | 43/18723 | 2.01e-08 | 1.63e-06 | 15 |
GO:00610776 | Stomach | GC | chaperone-mediated protein folding | 18/1159 | 67/18723 | 8.05e-08 | 5.15e-06 | 18 |
GO:0033559 | Stomach | GC | unsaturated fatty acid metabolic process | 24/1159 | 116/18723 | 1.43e-07 | 8.35e-06 | 24 |
GO:00510846 | Stomach | GC | 'de novo' posttranslational protein folding | 13/1159 | 39/18723 | 3.28e-07 | 1.75e-05 | 13 |
GO:0006690 | Stomach | GC | icosanoid metabolic process | 24/1159 | 123/18723 | 4.49e-07 | 2.32e-05 | 24 |
GO:00510856 | Stomach | GC | chaperone cofactor-dependent protein refolding | 12/1159 | 34/18723 | 4.59e-07 | 2.35e-05 | 12 |
GO:00316476 | Stomach | GC | regulation of protein stability | 40/1159 | 298/18723 | 3.23e-06 | 1.31e-04 | 40 |
GO:0006692 | Stomach | GC | prostanoid metabolic process | 13/1159 | 49/18723 | 5.93e-06 | 2.30e-04 | 13 |
GO:0006693 | Stomach | GC | prostaglandin metabolic process | 13/1159 | 49/18723 | 5.93e-06 | 2.30e-04 | 13 |
GO:00508216 | Stomach | GC | protein stabilization | 29/1159 | 191/18723 | 6.65e-06 | 2.54e-04 | 29 |
GO:0120254 | Stomach | GC | olefinic compound metabolic process | 25/1159 | 153/18723 | 7.68e-06 | 2.77e-04 | 25 |
GO:00485456 | Stomach | GC | response to steroid hormone | 42/1159 | 339/18723 | 1.40e-05 | 4.54e-04 | 42 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa052071 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGES3 | SNV | Missense_Mutation | novel | c.44N>A | p.Arg15Gln | p.R15Q | protein_coding | tolerated(0.06) | possibly_damaging(0.479) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | c.215G>C | p.Arg72Thr | p.R72T | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-D8-A27N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol+adriamycin+cyclophosphamide+herceptin | SD | ||
PTGES3 | SNV | Missense_Mutation | c.127A>G | p.Ser43Gly | p.S43G | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.112N>C | p.Ser38Pro | p.S38P | protein_coding | tolerated(0.08) | possibly_damaging(0.631) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PTGES3 | SNV | Missense_Mutation | c.365N>G | p.Ser122Cys | p.S122C | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.398A>G | p.Asn133Ser | p.N133S | protein_coding | tolerated(0.25) | benign(0.02) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | c.28G>A | p.Ala10Thr | p.A10T | protein_coding | tolerated(0.53) | benign(0.343) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.232T>G | p.Leu78Val | p.L78V | protein_coding | tolerated(0.38) | benign(0.143) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | novel | c.403N>T | p.Gly135Cys | p.G135C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | novel | c.20N>A | p.Pro7His | p.P7H | protein_coding | tolerated(0.24) | benign(0.108) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10728 | PTGES3 | ENZYME | GENISTEIN | GENISTEIN | 15229138 | |
10728 | PTGES3 | ENZYME | DIETHYLSTILBESTROL | DIETHYLSTILBESTROL | 15229138 | |
10728 | PTGES3 | ENZYME | GEDUNIN | GEDUNIN | 25756299 |
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