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Gene: PICALM |
Gene summary for PICALM |
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Gene information | Species | Human | Gene symbol | PICALM | Gene ID | 8301 |
Gene name | phosphatidylinositol binding clathrin assembly protein | |
Gene Alias | CALM | |
Cytomap | 11q14.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R5L7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8301 | PICALM | CCI_2 | Human | Cervix | CC | 3.23e-10 | 1.19e+00 | 0.5249 |
8301 | PICALM | CCI_3 | Human | Cervix | CC | 2.00e-12 | 1.10e+00 | 0.516 |
8301 | PICALM | sample3 | Human | Cervix | CC | 3.87e-04 | 1.97e-01 | 0.1387 |
8301 | PICALM | T3 | Human | Cervix | CC | 3.49e-05 | 2.00e-01 | 0.1389 |
8301 | PICALM | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.07e-11 | -4.90e-01 | 0.0155 |
8301 | PICALM | HTA11_696_2000001011 | Human | Colorectum | AD | 1.54e-05 | -3.44e-01 | -0.1464 |
8301 | PICALM | HTA11_866_3004761011 | Human | Colorectum | AD | 5.22e-13 | -5.51e-01 | 0.096 |
8301 | PICALM | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.15e-03 | -5.38e-01 | 0.0528 |
8301 | PICALM | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.90e-20 | -4.77e-01 | 0.0674 |
8301 | PICALM | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.15e-03 | -4.42e-01 | 0.0588 |
8301 | PICALM | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.97e-02 | -4.39e-01 | 0.2585 |
8301 | PICALM | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.28e-28 | -6.22e-01 | 0.3005 |
8301 | PICALM | A002-C-010 | Human | Colorectum | FAP | 6.48e-03 | -1.80e-01 | 0.242 |
8301 | PICALM | A001-C-207 | Human | Colorectum | FAP | 2.67e-04 | -2.93e-01 | 0.1278 |
8301 | PICALM | A015-C-203 | Human | Colorectum | FAP | 7.74e-43 | -6.39e-01 | -0.1294 |
8301 | PICALM | A015-C-204 | Human | Colorectum | FAP | 2.19e-11 | -4.34e-01 | -0.0228 |
8301 | PICALM | A014-C-040 | Human | Colorectum | FAP | 1.46e-07 | -6.11e-01 | -0.1184 |
8301 | PICALM | A002-C-201 | Human | Colorectum | FAP | 3.19e-20 | -4.90e-01 | 0.0324 |
8301 | PICALM | A002-C-203 | Human | Colorectum | FAP | 9.37e-08 | -2.93e-01 | 0.2786 |
8301 | PICALM | A001-C-119 | Human | Colorectum | FAP | 5.15e-12 | -5.34e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605031 | Oral cavity | NEOLP | vesicle organization | 52/2005 | 300/18723 | 3.20e-04 | 3.11e-03 | 52 |
GO:007099732 | Oral cavity | NEOLP | neuron death | 60/2005 | 361/18723 | 3.70e-04 | 3.50e-03 | 60 |
GO:005164831 | Oral cavity | NEOLP | vesicle localization | 34/2005 | 177/18723 | 5.23e-04 | 4.61e-03 | 34 |
GO:001619731 | Oral cavity | NEOLP | endosomal transport | 41/2005 | 230/18723 | 7.41e-04 | 6.05e-03 | 41 |
GO:005105113 | Oral cavity | NEOLP | negative regulation of transport | 72/2005 | 470/18723 | 1.14e-03 | 8.49e-03 | 72 |
GO:001095032 | Oral cavity | NEOLP | positive regulation of endopeptidase activity | 33/2005 | 179/18723 | 1.30e-03 | 9.46e-03 | 33 |
GO:190121431 | Oral cavity | NEOLP | regulation of neuron death | 52/2005 | 319/18723 | 1.37e-03 | 9.77e-03 | 52 |
GO:003545912 | Oral cavity | NEOLP | vesicle cargo loading | 9/2005 | 27/18723 | 1.41e-03 | 1.01e-02 | 9 |
GO:00906475 | Oral cavity | NEOLP | modulation of age-related behavioral decline | 5/2005 | 10/18723 | 2.22e-03 | 1.44e-02 | 5 |
GO:00429822 | Oral cavity | NEOLP | amyloid precursor protein metabolic process | 20/2005 | 95/18723 | 2.28e-03 | 1.47e-02 | 20 |
GO:004308722 | Oral cavity | NEOLP | regulation of GTPase activity | 54/2005 | 348/18723 | 3.36e-03 | 2.00e-02 | 54 |
GO:004298721 | Oral cavity | NEOLP | amyloid precursor protein catabolic process | 15/2005 | 68/18723 | 4.87e-03 | 2.65e-02 | 15 |
GO:009724212 | Oral cavity | NEOLP | amyloid-beta clearance | 10/2005 | 38/18723 | 5.51e-03 | 2.93e-02 | 10 |
GO:007170921 | Oral cavity | NEOLP | membrane assembly | 12/2005 | 50/18723 | 5.55e-03 | 2.95e-02 | 12 |
GO:190547531 | Oral cavity | NEOLP | regulation of protein localization to membrane | 30/2005 | 175/18723 | 6.34e-03 | 3.29e-02 | 30 |
GO:190307631 | Oral cavity | NEOLP | regulation of protein localization to plasma membrane | 20/2005 | 104/18723 | 6.71e-03 | 3.42e-02 | 20 |
GO:004586218 | Prostate | BPH | positive regulation of proteolysis | 121/3107 | 372/18723 | 2.05e-14 | 2.44e-12 | 121 |
GO:003425017 | Prostate | BPH | positive regulation of cellular amide metabolic process | 67/3107 | 162/18723 | 5.89e-14 | 6.51e-12 | 67 |
GO:005254718 | Prostate | BPH | regulation of peptidase activity | 133/3107 | 461/18723 | 2.08e-11 | 1.43e-09 | 133 |
GO:007265916 | Prostate | BPH | protein localization to plasma membrane | 89/3107 | 284/18723 | 5.00e-10 | 2.56e-08 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PICALM | SNV | Missense_Mutation | c.1625C>T | p.Ser542Leu | p.S542L | Q13492 | protein_coding | deleterious(0.02) | possibly_damaging(0.471) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PICALM | SNV | Missense_Mutation | novel | c.1612N>A | p.Asp538Asn | p.D538N | Q13492 | protein_coding | tolerated(1) | benign(0.015) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PICALM | SNV | Missense_Mutation | c.886N>A | p.Ala296Thr | p.A296T | Q13492 | protein_coding | tolerated(0.05) | benign(0.063) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
PICALM | insertion | Nonsense_Mutation | novel | c.1866_1867insTAAGAAAGAT | p.Met623Ter | p.M623* | Q13492 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PICALM | SNV | Missense_Mutation | novel | c.887N>T | p.Ala296Val | p.A296V | Q13492 | protein_coding | deleterious(0.02) | possibly_damaging(0.719) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PICALM | SNV | Missense_Mutation | c.59C>T | p.Ser20Phe | p.S20F | Q13492 | protein_coding | deleterious(0) | possibly_damaging(0.686) | TCGA-EA-A3HT-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
PICALM | SNV | Missense_Mutation | c.632A>G | p.Tyr211Cys | p.Y211C | Q13492 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
PICALM | SNV | Missense_Mutation | rs377101068 | c.1777N>G | p.Met593Val | p.M593V | Q13492 | protein_coding | tolerated(0.34) | benign(0.019) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
PICALM | SNV | Missense_Mutation | rs760482423 | c.1228N>G | p.Thr410Ala | p.T410A | Q13492 | protein_coding | tolerated(0.76) | benign(0.003) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PICALM | SNV | Missense_Mutation | novel | c.523A>G | p.Met175Val | p.M175V | Q13492 | protein_coding | tolerated(0.08) | benign(0.106) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8301 | PICALM | CLINICALLY ACTIONABLE, CELL SURFACE | calcium channel blockers | 24192120 |
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