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Gene: GAL |
Gene summary for GAL |
Gene summary. |
Gene information | Species | Human | Gene symbol | GAL | Gene ID | 51083 |
Gene name | galanin and GMAP prepropeptide | |
Gene Alias | ETL8 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P22466 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51083 | GAL | P5T-E | Human | Esophagus | ESCC | 7.98e-43 | 1.22e+00 | 0.1327 |
51083 | GAL | P10T-E | Human | Esophagus | ESCC | 3.36e-11 | 3.23e-01 | 0.116 |
51083 | GAL | P12T-E | Human | Esophagus | ESCC | 4.45e-03 | 2.22e-01 | 0.1122 |
51083 | GAL | P16T-E | Human | Esophagus | ESCC | 2.35e-24 | 6.39e-01 | 0.1153 |
51083 | GAL | P19T-E | Human | Esophagus | ESCC | 4.52e-04 | 5.76e-01 | 0.1662 |
51083 | GAL | P22T-E | Human | Esophagus | ESCC | 2.35e-16 | 7.16e-01 | 0.1236 |
51083 | GAL | P24T-E | Human | Esophagus | ESCC | 1.52e-35 | 1.52e+00 | 0.1287 |
51083 | GAL | P28T-E | Human | Esophagus | ESCC | 1.63e-103 | 4.67e+00 | 0.1149 |
51083 | GAL | P31T-E | Human | Esophagus | ESCC | 2.56e-02 | 2.54e-01 | 0.1251 |
51083 | GAL | P32T-E | Human | Esophagus | ESCC | 7.92e-40 | 1.90e+00 | 0.1666 |
51083 | GAL | P37T-E | Human | Esophagus | ESCC | 1.58e-12 | 7.11e-01 | 0.1371 |
51083 | GAL | P38T-E | Human | Esophagus | ESCC | 1.11e-08 | 5.00e-01 | 0.127 |
51083 | GAL | P40T-E | Human | Esophagus | ESCC | 1.70e-10 | 1.03e+00 | 0.109 |
51083 | GAL | P47T-E | Human | Esophagus | ESCC | 5.70e-04 | 2.40e-01 | 0.1067 |
51083 | GAL | P49T-E | Human | Esophagus | ESCC | 4.61e-02 | 4.13e-01 | 0.1768 |
51083 | GAL | P52T-E | Human | Esophagus | ESCC | 3.07e-23 | 6.53e-01 | 0.1555 |
51083 | GAL | P56T-E | Human | Esophagus | ESCC | 6.74e-08 | 1.55e+00 | 0.1613 |
51083 | GAL | P62T-E | Human | Esophagus | ESCC | 1.70e-02 | 1.47e-01 | 0.1302 |
51083 | GAL | P74T-E | Human | Esophagus | ESCC | 1.86e-23 | 9.61e-01 | 0.1479 |
51083 | GAL | P76T-E | Human | Esophagus | ESCC | 3.84e-11 | 3.91e-01 | 0.1207 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00193181 | Colorectum | SER | hexose metabolic process | 56/2897 | 237/18723 | 6.19e-04 | 8.42e-03 | 56 |
GO:2001236 | Colorectum | SER | regulation of extrinsic apoptotic signaling pathway | 39/2897 | 151/18723 | 6.67e-04 | 8.94e-03 | 39 |
GO:00457851 | Colorectum | SER | positive regulation of cell adhesion | 93/2897 | 437/18723 | 6.78e-04 | 9.04e-03 | 93 |
GO:19039021 | Colorectum | SER | positive regulation of viral life cycle | 12/2897 | 29/18723 | 7.22e-04 | 9.44e-03 | 12 |
GO:0007162 | Colorectum | SER | negative regulation of cell adhesion | 68/2897 | 303/18723 | 8.02e-04 | 1.01e-02 | 68 |
GO:0051346 | Colorectum | SER | negative regulation of hydrolase activity | 82/2897 | 379/18723 | 8.19e-04 | 1.01e-02 | 82 |
GO:19039001 | Colorectum | SER | regulation of viral life cycle | 38/2897 | 148/18723 | 8.76e-04 | 1.06e-02 | 38 |
GO:00059961 | Colorectum | SER | monosaccharide metabolic process | 59/2897 | 257/18723 | 9.65e-04 | 1.15e-02 | 59 |
GO:0051051 | Colorectum | SER | negative regulation of transport | 98/2897 | 470/18723 | 1.01e-03 | 1.19e-02 | 98 |
GO:20012671 | Colorectum | SER | regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 8/2897 | 16/18723 | 1.30e-03 | 1.45e-02 | 8 |
GO:2001237 | Colorectum | SER | negative regulation of extrinsic apoptotic signaling pathway | 27/2897 | 97/18723 | 1.31e-03 | 1.45e-02 | 27 |
GO:00109211 | Colorectum | SER | regulation of phosphatase activity | 24/2897 | 84/18723 | 1.61e-03 | 1.71e-02 | 24 |
GO:00353031 | Colorectum | SER | regulation of dephosphorylation | 33/2897 | 128/18723 | 1.71e-03 | 1.78e-02 | 33 |
GO:00160521 | Colorectum | SER | carbohydrate catabolic process | 38/2897 | 154/18723 | 1.92e-03 | 1.93e-02 | 38 |
GO:00467181 | Colorectum | SER | viral entry into host cell | 36/2897 | 144/18723 | 1.95e-03 | 1.96e-02 | 36 |
GO:00432801 | Colorectum | SER | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 33/2897 | 129/18723 | 1.97e-03 | 1.97e-02 | 33 |
GO:00353041 | Colorectum | SER | regulation of protein dephosphorylation | 25/2897 | 90/18723 | 2.00e-03 | 1.98e-02 | 25 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:00060061 | Colorectum | SER | glucose metabolic process | 46/2897 | 196/18723 | 2.08e-03 | 2.05e-02 | 46 |
GO:00436661 | Colorectum | SER | regulation of phosphoprotein phosphatase activity | 18/2897 | 58/18723 | 2.18e-03 | 2.11e-02 | 18 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | ADJ |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | ADJ |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | ADJ |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | ADJ |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | DCIS |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | DCIS |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | DCIS |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | DCIS |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | Healthy |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | Healthy |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | Healthy |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Breast | IDC |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Breast | IDC |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Breast | IDC |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Breast | IDC |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Cervix | ADJ |
ICAM2 | ITGAL_ITGB2 | ICAM2_ITGAL_ITGB2 | ICAM | Cervix | ADJ |
ICAM1 | ITGAL | ICAM1_ITGAL | ICAM | Cervix | ADJ |
F11R | ITGAL_ITGB2 | JAM1_ITGAL_ITGB2 | JAM | Cervix | ADJ |
ICAM1 | ITGAL_ITGB2 | ICAM1_ITGAL_ITGB2 | ICAM | Cervix | CC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAL | SNV | Missense_Mutation | c.88G>A | p.Glu30Lys | p.E30K | P22466 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A2-A0CW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
GAL | SNV | Missense_Mutation | c.142N>T | p.Val48Phe | p.V48F | P22466 | protein_coding | deleterious(0) | possibly_damaging(0.595) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GAL | SNV | Missense_Mutation | rs770751421 | c.115G>A | p.Ala39Thr | p.A39T | P22466 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
GAL | SNV | Missense_Mutation | novel | c.62N>T | p.Ser21Phe | p.S21F | P22466 | protein_coding | deleterious(0) | benign(0.202) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
GAL | SNV | Missense_Mutation | rs540782765 | c.340N>A | p.Ala114Thr | p.A114T | P22466 | protein_coding | tolerated(0.22) | benign(0.055) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GAL | SNV | Missense_Mutation | rs762637870 | c.337N>A | p.Ala113Thr | p.A113T | P22466 | protein_coding | tolerated(0.98) | benign(0.003) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
GAL | SNV | Missense_Mutation | novel | c.50N>T | p.Ala17Val | p.A17V | P22466 | protein_coding | tolerated(0.44) | benign(0.14) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GAL | SNV | Missense_Mutation | rs762637870 | c.337G>A | p.Ala113Thr | p.A113T | P22466 | protein_coding | tolerated(0.98) | benign(0.003) | TCGA-B5-A0JU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GAL | SNV | Missense_Mutation | novel | c.256A>G | p.Ile86Val | p.I86V | P22466 | protein_coding | tolerated(0.77) | benign(0.001) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GAL | SNV | Missense_Mutation | rs778530092 | c.263N>A | p.Arg88His | p.R88H | P22466 | protein_coding | tolerated(0.39) | benign(0.026) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51083 | GAL | DRUGGABLE GENOME | Selective serotonin reuptake inhibitors | |||
51083 | GAL | DRUGGABLE GENOME | CORTISOL | HYDROCORTISONE | 17982695 | |
51083 | GAL | DRUGGABLE GENOME | opioids | |||
51083 | GAL | DRUGGABLE GENOME | mirtazapine | MIRTAZAPINE | ||
51083 | GAL | DRUGGABLE GENOME | DHEA | PRASTERONE | 12195234 | |
51083 | GAL | DRUGGABLE GENOME | heroin | DIACETYLMORPHINE | ||
51083 | GAL | DRUGGABLE GENOME | IMMUNOTOXIN | 9189270 | ||
51083 | GAL | DRUGGABLE GENOME | TRIIODOTHYRONINE | LIOTHYRONINE SODIUM | 12147214 | |
51083 | GAL | DRUGGABLE GENOME | ESTRADIOL BENZOATE | 14666144 | ||
51083 | GAL | DRUGGABLE GENOME | antidepressants |
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