Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/NEDD4L_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NEDD4L_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NEDD4L_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/NEDD4L_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NEDD4L_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/NEDD4L_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NEDD4L_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/NEDD4L_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NEDD4L_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NEDD4L_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NEDD4L_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NEDD4L_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217621 | Stomach | CSG | regulation of protein catabolic process | 44/1034 | 391/18723 | 5.92e-06 | 2.24e-04 | 44 |
GO:003004821 | Stomach | CSG | actin filament-based movement | 20/1034 | 127/18723 | 2.09e-05 | 6.18e-04 | 20 |
GO:000989621 | Stomach | CSG | positive regulation of catabolic process | 46/1034 | 492/18723 | 3.45e-04 | 5.74e-03 | 46 |
GO:004573221 | Stomach | CSG | positive regulation of protein catabolic process | 26/1034 | 231/18723 | 4.55e-04 | 7.10e-03 | 26 |
GO:001049811 | Stomach | CSG | proteasomal protein catabolic process | 44/1034 | 490/18723 | 1.06e-03 | 1.34e-02 | 44 |
GO:190230521 | Stomach | CSG | regulation of sodium ion transmembrane transport | 11/1034 | 68/18723 | 1.17e-03 | 1.42e-02 | 11 |
GO:200064921 | Stomach | CSG | regulation of sodium ion transmembrane transporter activity | 10/1034 | 58/18723 | 1.17e-03 | 1.42e-02 | 10 |
GO:008600321 | Stomach | CSG | cardiac muscle cell contraction | 11/1034 | 73/18723 | 2.11e-03 | 2.18e-02 | 11 |
GO:007025221 | Stomach | CSG | actin-mediated cell contraction | 13/1034 | 97/18723 | 2.58e-03 | 2.50e-02 | 13 |
GO:00109592 | Stomach | CSG | regulation of metal ion transport | 36/1034 | 406/18723 | 3.54e-03 | 3.18e-02 | 36 |
GO:004316111 | Stomach | CSG | proteasome-mediated ubiquitin-dependent protein catabolic process | 36/1034 | 412/18723 | 4.49e-03 | 3.79e-02 | 36 |
GO:00518991 | Stomach | CSG | membrane depolarization | 11/1034 | 83/18723 | 5.82e-03 | 4.62e-02 | 11 |
GO:001003831 | Stomach | CAG | response to metal ion | 34/552 | 373/18723 | 6.12e-09 | 8.53e-07 | 34 |
GO:003164731 | Stomach | CAG | regulation of protein stability | 28/552 | 298/18723 | 7.20e-08 | 7.30e-06 | 28 |
GO:004217631 | Stomach | CAG | regulation of protein catabolic process | 30/552 | 391/18723 | 1.94e-06 | 1.11e-04 | 30 |
GO:004573231 | Stomach | CAG | positive regulation of protein catabolic process | 17/552 | 231/18723 | 5.21e-04 | 8.77e-03 | 17 |
GO:002260431 | Stomach | CAG | regulation of cell morphogenesis | 19/552 | 309/18723 | 2.15e-03 | 2.43e-02 | 19 |
GO:00109593 | Stomach | CAG | regulation of metal ion transport | 23/552 | 406/18723 | 2.26e-03 | 2.50e-02 | 23 |
GO:19038284 | Stomach | CAG | negative regulation of cellular protein localization | 10/552 | 117/18723 | 2.43e-03 | 2.61e-02 | 10 |
GO:001049821 | Stomach | CAG | proteasomal protein catabolic process | 26/552 | 490/18723 | 2.98e-03 | 3.00e-02 | 26 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEDD4L | SNV | Missense_Mutation | | c.1937C>A | p.Ala646Asp | p.A646D | Q96PU5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
NEDD4L | SNV | Missense_Mutation | | c.2518A>G | p.Ile840Val | p.I840V | Q96PU5 | protein_coding | tolerated(0.09) | benign(0.127) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NEDD4L | SNV | Missense_Mutation | | c.2003T>A | p.Phe668Tyr | p.F668Y | Q96PU5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NEDD4L | SNV | Missense_Mutation | | c.2848N>G | p.Pro950Ala | p.P950A | Q96PU5 | protein_coding | deleterious(0.02) | benign(0.031) | TCGA-AN-A03Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NEDD4L | SNV | Missense_Mutation | | c.1402N>G | p.Arg468Gly | p.R468G | Q96PU5 | protein_coding | tolerated(0.1) | benign(0.048) | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
NEDD4L | SNV | Missense_Mutation | | c.229G>C | p.Glu77Gln | p.E77Q | Q96PU5 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
NEDD4L | SNV | Missense_Mutation | | c.532G>C | p.Asp178His | p.D178H | Q96PU5 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-C8-A1HF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NEDD4L | SNV | Missense_Mutation | | c.52N>C | p.Glu18Gln | p.E18Q | Q96PU5 | protein_coding | tolerated(0.33) | benign(0.269) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
NEDD4L | SNV | Missense_Mutation | novel | c.2524N>C | p.Ile842Leu | p.I842L | Q96PU5 | protein_coding | tolerated(0.06) | benign(0.02) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
NEDD4L | SNV | Missense_Mutation | novel | c.2524N>G | p.Ile842Val | p.I842V | Q96PU5 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-WT-AB41-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |