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Gene: LGALS3 |
Gene summary for LGALS3 |
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Gene information | Species | Human | Gene symbol | LGALS3 | Gene ID | 3958 |
Gene name | galectin 3 | |
Gene Alias | CBP35 | |
Cytomap | 14q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001771 | UniProtAcc | A0A024R693 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3958 | LGALS3 | GSM4909282 | Human | Breast | IDC | 2.56e-31 | 5.20e-01 | -0.0288 |
3958 | LGALS3 | GSM4909285 | Human | Breast | IDC | 8.09e-06 | -1.89e-03 | 0.21 |
3958 | LGALS3 | GSM4909286 | Human | Breast | IDC | 8.15e-27 | -7.40e-01 | 0.1081 |
3958 | LGALS3 | GSM4909287 | Human | Breast | IDC | 3.35e-05 | -3.87e-01 | 0.2057 |
3958 | LGALS3 | GSM4909288 | Human | Breast | IDC | 2.73e-03 | -5.12e-01 | 0.0988 |
3958 | LGALS3 | GSM4909289 | Human | Breast | IDC | 6.51e-03 | -6.23e-01 | 0.1064 |
3958 | LGALS3 | GSM4909291 | Human | Breast | IDC | 1.07e-22 | -8.69e-01 | 0.1753 |
3958 | LGALS3 | GSM4909292 | Human | Breast | IDC | 4.39e-03 | -7.70e-01 | 0.1236 |
3958 | LGALS3 | GSM4909293 | Human | Breast | IDC | 3.33e-34 | -9.05e-01 | 0.1581 |
3958 | LGALS3 | GSM4909294 | Human | Breast | IDC | 1.93e-04 | -4.13e-01 | 0.2022 |
3958 | LGALS3 | GSM4909296 | Human | Breast | IDC | 1.91e-12 | -4.27e-01 | 0.1524 |
3958 | LGALS3 | GSM4909297 | Human | Breast | IDC | 7.26e-22 | -5.41e-01 | 0.1517 |
3958 | LGALS3 | GSM4909298 | Human | Breast | IDC | 1.94e-28 | -7.83e-01 | 0.1551 |
3958 | LGALS3 | GSM4909301 | Human | Breast | IDC | 2.69e-42 | -9.45e-01 | 0.1577 |
3958 | LGALS3 | GSM4909302 | Human | Breast | IDC | 1.03e-08 | -4.61e-01 | 0.1545 |
3958 | LGALS3 | GSM4909303 | Human | Breast | IDC | 2.71e-04 | -5.58e-01 | 0.0438 |
3958 | LGALS3 | GSM4909304 | Human | Breast | IDC | 8.27e-09 | -4.03e-01 | 0.1636 |
3958 | LGALS3 | GSM4909306 | Human | Breast | IDC | 7.44e-11 | -5.16e-01 | 0.1564 |
3958 | LGALS3 | GSM4909307 | Human | Breast | IDC | 9.74e-13 | -5.81e-01 | 0.1569 |
3958 | LGALS3 | GSM4909308 | Human | Breast | IDC | 9.97e-31 | -8.24e-01 | 0.158 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00086256 | Liver | Cirrhotic | extrinsic apoptotic signaling pathway via death domain receptors | 39/4634 | 82/18723 | 6.14e-06 | 9.82e-05 | 39 |
GO:20012377 | Liver | Cirrhotic | negative regulation of extrinsic apoptotic signaling pathway | 44/4634 | 97/18723 | 7.61e-06 | 1.15e-04 | 44 |
GO:19020416 | Liver | Cirrhotic | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 26/4634 | 49/18723 | 1.93e-05 | 2.57e-04 | 26 |
GO:00353047 | Liver | Cirrhotic | regulation of protein dephosphorylation | 39/4634 | 90/18723 | 8.57e-05 | 9.25e-04 | 39 |
GO:19054775 | Liver | Cirrhotic | positive regulation of protein localization to membrane | 44/4634 | 106/18723 | 1.07e-04 | 1.10e-03 | 44 |
GO:000647011 | Liver | Cirrhotic | protein dephosphorylation | 96/4634 | 281/18723 | 2.32e-04 | 2.11e-03 | 96 |
GO:003010011 | Liver | Cirrhotic | regulation of endocytosis | 74/4634 | 211/18723 | 4.86e-04 | 3.90e-03 | 74 |
GO:19043776 | Liver | Cirrhotic | positive regulation of protein localization to cell periphery | 30/4634 | 69/18723 | 5.04e-04 | 4.01e-03 | 30 |
GO:00482461 | Liver | Cirrhotic | macrophage chemotaxis | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:001631111 | Liver | Cirrhotic | dephosphorylation | 130/4634 | 417/18723 | 1.58e-03 | 1.03e-02 | 130 |
GO:00436666 | Liver | Cirrhotic | regulation of phosphoprotein phosphatase activity | 25/4634 | 58/18723 | 1.66e-03 | 1.07e-02 | 25 |
GO:19055171 | Liver | Cirrhotic | macrophage migration | 24/4634 | 55/18723 | 1.67e-03 | 1.07e-02 | 24 |
GO:19030786 | Liver | Cirrhotic | positive regulation of protein localization to plasma membrane | 26/4634 | 62/18723 | 2.18e-03 | 1.34e-02 | 26 |
GO:00508602 | Liver | Cirrhotic | negative regulation of T cell receptor signaling pathway | 12/4634 | 22/18723 | 2.61e-03 | 1.53e-02 | 12 |
GO:00510514 | Liver | Cirrhotic | negative regulation of transport | 141/4634 | 470/18723 | 5.06e-03 | 2.62e-02 | 141 |
GO:00026876 | Liver | Cirrhotic | positive regulation of leukocyte migration | 47/4634 | 135/18723 | 5.55e-03 | 2.81e-02 | 47 |
GO:00353037 | Liver | Cirrhotic | regulation of dephosphorylation | 44/4634 | 128/18723 | 9.13e-03 | 4.21e-02 | 44 |
GO:00353084 | Liver | Cirrhotic | negative regulation of protein dephosphorylation | 15/4634 | 34/18723 | 1.05e-02 | 4.66e-02 | 15 |
GO:00071624 | Liver | Cirrhotic | negative regulation of cell adhesion | 93/4634 | 303/18723 | 1.06e-02 | 4.66e-02 | 93 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGALS3 | SNV | Missense_Mutation | c.649C>T | p.His217Tyr | p.H217Y | P17931 | protein_coding | deleterious(0.03) | probably_damaging(0.915) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | c.594C>G | p.Phe198Leu | p.F198L | P17931 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
LGALS3 | SNV | Missense_Mutation | novel | c.734N>T | p.Ala245Val | p.A245V | P17931 | protein_coding | tolerated(1) | benign(0.044) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LGALS3 | SNV | Missense_Mutation | c.193N>A | p.Gly65Arg | p.G65R | P17931 | protein_coding | deleterious(0) | possibly_damaging(0.619) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | c.182N>A | p.Gly61Asp | p.G61D | P17931 | protein_coding | deleterious(0.03) | possibly_damaging(0.684) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | rs201398647 | c.386N>A | p.Arg129His | p.R129H | P17931 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LGALS3 | SNV | Missense_Mutation | c.695G>A | p.Ser232Asn | p.S232N | P17931 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | novel | c.367N>T | p.Pro123Ser | p.P123S | P17931 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LGALS3 | deletion | Frame_Shift_Del | novel | c.152delC | p.Pro51GlnfsTer64 | p.P51Qfs*64 | P17931 | protein_coding | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LGALS3 | SNV | Missense_Mutation | novel | c.38N>T | p.Gly13Val | p.G13V | P17931 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3958 | LGALS3 | CELL SURFACE, DRUGGABLE GENOME | LACTOSE, ANHYDROUS | LACTOSE, ANHYDROUS | 21524586 | |
3958 | LGALS3 | CELL SURFACE, DRUGGABLE GENOME | GR-MD-02 | BELAPECTIN | ||
3958 | LGALS3 | CELL SURFACE, DRUGGABLE GENOME | Antibiotics | 25869013 |
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