Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: EPS8

Gene summary for EPS8

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

EPS8

Gene ID

2059

Gene nameepidermal growth factor receptor pathway substrate 8
Gene AliasDFNB102
Cytomap12p12.3
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

B4E3T6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2059EPS8HTA11_3410_2000001011HumanColorectumAD7.86e-43-1.07e+000.0155
2059EPS8HTA11_2951_2000001011HumanColorectumAD1.06e-03-8.33e-010.0216
2059EPS8HTA11_3361_2000001011HumanColorectumAD5.36e-21-1.03e+00-0.1207
2059EPS8HTA11_83_2000001011HumanColorectumSER5.83e-08-5.93e-01-0.1526
2059EPS8HTA11_696_2000001011HumanColorectumAD9.16e-33-5.86e-01-0.1464
2059EPS8HTA11_866_2000001011HumanColorectumAD2.63e-16-5.56e-01-0.1001
2059EPS8HTA11_1391_2000001011HumanColorectumAD4.43e-04-5.49e-01-0.059
2059EPS8HTA11_5212_2000001011HumanColorectumAD9.94e-03-5.51e-01-0.2061
2059EPS8HTA11_546_2000001011HumanColorectumAD3.92e-03-6.16e-01-0.0842
2059EPS8HTA11_9341_2000001011HumanColorectumSER6.34e-05-1.12e+00-0.00410000000000005
2059EPS8HTA11_7862_2000001011HumanColorectumAD1.20e-06-5.79e-01-0.0179
2059EPS8HTA11_866_3004761011HumanColorectumAD1.58e-10-7.09e-010.096
2059EPS8HTA11_4255_2000001011HumanColorectumSER2.26e-04-9.36e-010.0446
2059EPS8HTA11_9408_2000001011HumanColorectumAD1.84e-02-8.31e-010.0451
2059EPS8HTA11_8622_2000001021HumanColorectumSER5.74e-08-1.01e+000.0528
2059EPS8HTA11_7663_2000001011HumanColorectumSER4.92e-03-6.52e-010.0131
2059EPS8HTA11_10623_2000001011HumanColorectumAD4.23e-03-5.79e-01-0.0177
2059EPS8HTA11_6801_2000001011HumanColorectumSER3.65e-02-8.03e-010.0171
2059EPS8HTA11_10711_2000001011HumanColorectumAD2.97e-18-8.78e-010.0338
2059EPS8HTA11_7696_3000711011HumanColorectumAD1.96e-23-6.52e-010.0674
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:19018803Oral cavityNEOLPnegative regulation of protein depolymerization16/200572/187233.43e-032.04e-0216
GO:001660122Oral cavityNEOLPRac protein signal transduction11/200542/187233.82e-032.19e-0211
GO:003083412Oral cavityNEOLPregulation of actin filament depolymerization13/200554/187233.86e-032.21e-0213
GO:00308357Oral cavityNEOLPnegative regulation of actin filament depolymerization11/200545/187236.72e-033.42e-0211
GO:00083441Oral cavityNEOLPadult locomotory behavior15/200571/187237.39e-033.73e-0215
GO:00300427Oral cavityNEOLPactin filament depolymerization13/200559/187238.52e-034.15e-0213
GO:00516936Oral cavityNEOLPactin filament capping10/200541/187239.71e-034.55e-0210
GO:190290318ProstateBPHregulation of supramolecular fiber organization133/3107383/187232.40e-188.73e-16133
GO:000701518ProstateBPHactin filament organization147/3107442/187233.36e-181.15e-15147
GO:003297018ProstateBPHregulation of actin filament-based process133/3107397/187237.07e-171.62e-14133
GO:003295618ProstateBPHregulation of actin cytoskeleton organization118/3107358/187231.51e-141.87e-12118
GO:004325418ProstateBPHregulation of protein-containing complex assembly133/3107428/187235.40e-146.08e-12133
GO:005101718ProstateBPHactin filament bundle assembly65/3107157/187231.31e-131.38e-1165
GO:011005318ProstateBPHregulation of actin filament organization96/3107278/187231.90e-131.89e-1196
GO:006157218ProstateBPHactin filament bundle organization65/3107161/187235.29e-134.75e-1165
GO:002260417ProstateBPHregulation of cell morphogenesis99/3107309/187231.30e-119.72e-1099
GO:005125818ProstateBPHprotein polymerization96/3107297/187231.52e-111.10e-0996
GO:003227118ProstateBPHregulation of protein polymerization80/3107233/187232.67e-111.78e-0980
GO:00072658ProstateBPHRas protein signal transduction101/3107337/187235.64e-102.79e-08101
GO:000815416ProstateBPHactin polymerization or depolymerization72/3107218/187231.82e-097.59e-0872
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
EPS8SNVMissense_Mutationc.982N>Cp.Phe328Leup.F328LQ12929protein_codingtolerated(0.05)possibly_damaging(0.533)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
EPS8SNVMissense_Mutationc.1785G>Tp.Leu595Phep.L595FQ12929protein_codingtolerated(0.32)benign(0.003)TCGA-AO-A0JC-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
EPS8SNVMissense_Mutationc.1508A>Gp.His503Argp.H503RQ12929protein_codingtolerated(0.35)benign(0)TCGA-AQ-A04H-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapytaxotereSD
EPS8SNVMissense_Mutationc.220N>Tp.Val74Phep.V74FQ12929protein_codingdeleterious(0)possibly_damaging(0.57)TCGA-B6-A0RP-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
EPS8SNVMissense_Mutationrs776013800c.287C>Gp.Ala96Glyp.A96GQ12929protein_codingdeleterious(0.01)possibly_damaging(0.574)TCGA-C8-A26Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
EPS8SNVMissense_Mutationrs369986759c.794N>Ap.Arg265Hisp.R265HQ12929protein_codingdeleterious(0)benign(0.097)TCGA-D8-A1J8-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapynolvadexSD
EPS8SNVMissense_Mutationc.1313A>Tp.Glu438Valp.E438VQ12929protein_codingdeleterious(0)possibly_damaging(0.459)TCGA-E9-A22G-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
EPS8insertionFrame_Shift_Insnovelc.2371_2372insTTGCTGTTTTAGGTAGTATGGCCATTTTCACp.Ser791PhefsTer29p.S791Ffs*29Q12929protein_codingTCGA-A2-A0EY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
EPS8SNVMissense_Mutationrs147224631c.1300N>Tp.Arg434Cysp.R434CQ12929protein_codingdeleterious(0)benign(0.125)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
EPS8SNVMissense_Mutationc.1499N>Cp.Arg500Thrp.R500TQ12929protein_codingtolerated(0.08)benign(0.024)TCGA-EK-A2RJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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