Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CCT3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CCT3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CCT3_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CCT3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CCT3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CCT3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CCT3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CCT3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CCT3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005105419 | Skin | cSCC | positive regulation of DNA metabolic process | 80/4864 | 201/18723 | 1.16e-05 | 1.50e-04 | 80 |
GO:00702039 | Skin | cSCC | regulation of establishment of protein localization to telomere | 10/4864 | 11/18723 | 1.17e-05 | 1.50e-04 | 10 |
GO:19048699 | Skin | cSCC | regulation of protein localization to Cajal body | 10/4864 | 11/18723 | 1.17e-05 | 1.50e-04 | 10 |
GO:19048719 | Skin | cSCC | positive regulation of protein localization to Cajal body | 10/4864 | 11/18723 | 1.17e-05 | 1.50e-04 | 10 |
GO:1904358110 | Skin | cSCC | positive regulation of telomere maintenance via telomere lengthening | 22/4864 | 37/18723 | 1.71e-05 | 2.07e-04 | 22 |
GO:190485118 | Skin | cSCC | positive regulation of establishment of protein localization to telomere | 9/4864 | 10/18723 | 4.11e-05 | 4.34e-04 | 9 |
GO:003221217 | Skin | cSCC | positive regulation of telomere maintenance via telomerase | 20/4864 | 34/18723 | 5.14e-05 | 5.28e-04 | 20 |
GO:19034058 | Skin | cSCC | protein localization to nuclear body | 10/4864 | 12/18723 | 5.36e-05 | 5.38e-04 | 10 |
GO:19048168 | Skin | cSCC | positive regulation of protein localization to chromosome, telomeric region | 10/4864 | 12/18723 | 5.36e-05 | 5.38e-04 | 10 |
GO:19048678 | Skin | cSCC | protein localization to Cajal body | 10/4864 | 12/18723 | 5.36e-05 | 5.38e-04 | 10 |
GO:19048148 | Skin | cSCC | regulation of protein localization to chromosome, telomeric region | 11/4864 | 14/18723 | 5.83e-05 | 5.75e-04 | 11 |
GO:2000573110 | Skin | cSCC | positive regulation of DNA biosynthetic process | 32/4864 | 66/18723 | 7.02e-05 | 6.79e-04 | 32 |
GO:00701988 | Skin | cSCC | protein localization to chromosome, telomeric region | 17/4864 | 29/18723 | 2.00e-04 | 1.67e-03 | 17 |
GO:00701997 | Skin | cSCC | establishment of protein localization to chromosome | 15/4864 | 25/18723 | 3.36e-04 | 2.67e-03 | 15 |
GO:00702008 | Skin | cSCC | establishment of protein localization to telomere | 11/4864 | 16/18723 | 4.08e-04 | 3.18e-03 | 11 |
GO:00469317 | Skin | cSCC | pore complex assembly | 12/4864 | 20/18723 | 1.34e-03 | 8.54e-03 | 12 |
GO:19019988 | Skin | cSCC | toxin transport | 18/4864 | 40/18723 | 7.10e-03 | 3.40e-02 | 18 |
GO:0072594112 | Thyroid | PTC | establishment of protein localization to organelle | 244/5968 | 422/18723 | 1.18e-28 | 4.97e-26 | 244 |
GO:0006457112 | Thyroid | PTC | protein folding | 137/5968 | 212/18723 | 8.29e-23 | 2.01e-20 | 137 |
GO:0006403112 | Thyroid | PTC | RNA localization | 130/5968 | 201/18723 | 9.23e-22 | 1.94e-19 | 130 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT3 | SNV | Missense_Mutation | novel | c.1345C>A | p.Arg449Ser | p.R449S | P49368 | protein_coding | deleterious(0.04) | possibly_damaging(0.531) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CCT3 | SNV | Missense_Mutation | rs763340746 | c.1535N>T | p.Thr512Met | p.T512M | P49368 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
CCT3 | SNV | Missense_Mutation | | c.773N>G | p.Ile258Ser | p.I258S | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
CCT3 | SNV | Missense_Mutation | rs746245572 | c.710N>A | p.Arg237His | p.R237H | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-D8-A1XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
CCT3 | SNV | Missense_Mutation | | c.1447G>A | p.Glu483Lys | p.E483K | P49368 | protein_coding | tolerated(0.47) | benign(0.013) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
CCT3 | insertion | Nonsense_Mutation | novel | c.1227_1228insAAGACCTAACTTTATGGTTAG | p.Pro409_Gly410insLysThrTerLeuTyrGlyTer | p.P409_G410insKT*LYG* | P49368 | protein_coding | | | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCT3 | insertion | Nonsense_Mutation | novel | c.1225_1226insTAGCATAATGGA | p.Pro409delinsLeuAlaTerTrpThr | p.P409delinsLA*WT | P49368 | protein_coding | | | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCT3 | SNV | Missense_Mutation | rs375964353 | c.688C>T | p.Arg230Trp | p.R230W | P49368 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CCT3 | SNV | Missense_Mutation | rs373870763 | c.1567G>A | p.Val523Ile | p.V523I | P49368 | protein_coding | tolerated(0.29) | possibly_damaging(0.546) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCT3 | SNV | Missense_Mutation | novel | c.59G>T | p.Arg20Ile | p.R20I | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |