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Gene: PNP |
Gene summary for PNP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PNP | Gene ID | 4860 |
| Gene name | purine nucleoside phosphorylase | |
| Gene Alias | NP | |
| Cytomap | 14q11.2 | |
| Gene Type | protein-coding | GO ID | GO:0000255 | UniProtAcc | P00491 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4860 | PNP | LZE5T | Human | Esophagus | ESCC | 2.61e-04 | -2.12e-01 | 0.0514 |
| 4860 | PNP | LZE7T | Human | Esophagus | ESCC | 1.30e-04 | 4.39e-02 | 0.0667 |
| 4860 | PNP | LZE8T | Human | Esophagus | ESCC | 3.72e-02 | -1.81e-01 | 0.067 |
| 4860 | PNP | LZE20T | Human | Esophagus | ESCC | 4.33e-05 | -6.62e-02 | 0.0662 |
| 4860 | PNP | LZE22D1 | Human | Esophagus | HGIN | 8.91e-05 | -3.66e-01 | 0.0595 |
| 4860 | PNP | P2T-E | Human | Esophagus | ESCC | 3.23e-05 | 3.00e-01 | 0.1177 |
| 4860 | PNP | P4T-E | Human | Esophagus | ESCC | 2.76e-14 | 9.17e-01 | 0.1323 |
| 4860 | PNP | P5T-E | Human | Esophagus | ESCC | 7.78e-13 | 6.22e-01 | 0.1327 |
| 4860 | PNP | P8T-E | Human | Esophagus | ESCC | 2.62e-05 | -7.14e-02 | 0.0889 |
| 4860 | PNP | P10T-E | Human | Esophagus | ESCC | 8.64e-04 | -2.14e-01 | 0.116 |
| 4860 | PNP | P11T-E | Human | Esophagus | ESCC | 2.32e-08 | 1.17e+00 | 0.1426 |
| 4860 | PNP | P12T-E | Human | Esophagus | ESCC | 1.55e-04 | 2.69e-01 | 0.1122 |
| 4860 | PNP | P15T-E | Human | Esophagus | ESCC | 7.28e-14 | 7.41e-01 | 0.1149 |
| 4860 | PNP | P16T-E | Human | Esophagus | ESCC | 3.18e-05 | 7.02e-02 | 0.1153 |
| 4860 | PNP | P21T-E | Human | Esophagus | ESCC | 3.63e-14 | 4.45e-01 | 0.1617 |
| 4860 | PNP | P22T-E | Human | Esophagus | ESCC | 7.28e-03 | 1.98e-01 | 0.1236 |
| 4860 | PNP | P23T-E | Human | Esophagus | ESCC | 5.50e-03 | 3.36e-01 | 0.108 |
| 4860 | PNP | P24T-E | Human | Esophagus | ESCC | 4.31e-03 | 2.39e-01 | 0.1287 |
| 4860 | PNP | P26T-E | Human | Esophagus | ESCC | 1.67e-07 | 4.57e-01 | 0.1276 |
| 4860 | PNP | P27T-E | Human | Esophagus | ESCC | 1.88e-11 | 5.75e-01 | 0.1055 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0046632 | Prostate | BPH | alpha-beta T cell differentiation | 29/3107 | 112/18723 | 8.07e-03 | 3.51e-02 | 29 |
| GO:00421299 | Prostate | BPH | regulation of T cell proliferation | 41/3107 | 171/18723 | 8.09e-03 | 3.52e-02 | 41 |
| GO:19021074 | Prostate | BPH | positive regulation of leukocyte differentiation | 38/3107 | 157/18723 | 8.96e-03 | 3.83e-02 | 38 |
| GO:19037084 | Prostate | BPH | positive regulation of hemopoiesis | 38/3107 | 157/18723 | 8.96e-03 | 3.83e-02 | 38 |
| GO:00091267 | Prostate | BPH | purine nucleoside monophosphate metabolic process | 14/3107 | 44/18723 | 9.52e-03 | 4.03e-02 | 14 |
| GO:19030399 | Prostate | BPH | positive regulation of leukocyte cell-cell adhesion | 54/3107 | 239/18723 | 9.57e-03 | 4.05e-02 | 54 |
| GO:00706639 | Prostate | BPH | regulation of leukocyte proliferation | 55/3107 | 245/18723 | 1.02e-02 | 4.29e-02 | 55 |
| GO:004209810 | Prostate | BPH | T cell proliferation | 46/3107 | 199/18723 | 1.05e-02 | 4.39e-02 | 46 |
| GO:000989619 | Prostate | Tumor | positive regulation of catabolic process | 155/3246 | 492/18723 | 5.62e-15 | 8.52e-13 | 155 |
| GO:000697919 | Prostate | Tumor | response to oxidative stress | 144/3246 | 446/18723 | 5.75e-15 | 8.52e-13 | 144 |
| GO:003133119 | Prostate | Tumor | positive regulation of cellular catabolic process | 134/3246 | 427/18723 | 5.54e-13 | 5.84e-11 | 134 |
| GO:006219719 | Prostate | Tumor | cellular response to chemical stress | 112/3246 | 337/18723 | 7.53e-13 | 7.67e-11 | 112 |
| GO:003459919 | Prostate | Tumor | cellular response to oxidative stress | 92/3246 | 288/18723 | 8.68e-10 | 4.22e-08 | 92 |
| GO:004578519 | Prostate | Tumor | positive regulation of cell adhesion | 125/3246 | 437/18723 | 2.56e-09 | 1.08e-07 | 125 |
| GO:000915019 | Prostate | Tumor | purine ribonucleotide metabolic process | 109/3246 | 368/18723 | 3.30e-09 | 1.36e-07 | 109 |
| GO:000925918 | Prostate | Tumor | ribonucleotide metabolic process | 110/3246 | 385/18723 | 2.45e-08 | 8.29e-07 | 110 |
| GO:000616319 | Prostate | Tumor | purine nucleotide metabolic process | 111/3246 | 396/18723 | 6.46e-08 | 1.88e-06 | 111 |
| GO:001969318 | Prostate | Tumor | ribose phosphate metabolic process | 111/3246 | 396/18723 | 6.46e-08 | 1.88e-06 | 111 |
| GO:007252119 | Prostate | Tumor | purine-containing compound metabolic process | 115/3246 | 416/18723 | 8.47e-08 | 2.31e-06 | 115 |
| GO:003465516 | Prostate | Tumor | nucleobase-containing compound catabolic process | 112/3246 | 407/18723 | 1.61e-07 | 4.02e-06 | 112 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
| hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
| hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
| hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
| hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
| hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PNP | SNV | Missense_Mutation | novel | c.416N>T | p.Pro139Leu | p.P139L | P00491 | protein_coding | tolerated(0.53) | benign(0.298) | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
| PNP | insertion | Nonsense_Mutation | novel | c.801_802insCCCCTTGTTCAGTAGCCTCTTCTTTAAGAA | p.Ala267_Ala268insProLeuValGlnTerProLeuLeuTerGlu | p.A267_A268insPLVQ*PLL*E | P00491 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| PNP | deletion | Frame_Shift_Del | novel | c.134delN | p.Gln46ArgfsTer28 | p.Q46Rfs*28 | P00491 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| PNP | SNV | Missense_Mutation | novel | c.611C>T | p.Ala204Val | p.A204V | P00491 | protein_coding | deleterious(0) | benign(0.158) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| PNP | SNV | Missense_Mutation | rs150531909 | c.482N>T | p.Ala161Val | p.A161V | P00491 | protein_coding | tolerated(0.07) | benign(0.183) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PNP | SNV | Missense_Mutation | c.839N>T | p.Ala280Val | p.A280V | P00491 | protein_coding | tolerated(0.16) | benign(0.012) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PNP | SNV | Missense_Mutation | rs755640590 | c.646N>A | p.Ala216Thr | p.A216T | P00491 | protein_coding | deleterious(0.05) | probably_damaging(0.914) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| PNP | SNV | Missense_Mutation | novel | c.71N>A | p.Arg24Gln | p.R24Q | P00491 | protein_coding | tolerated(0.06) | benign(0.021) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PNP | SNV | Missense_Mutation | rs769652649 | c.472N>T | p.Arg158Cys | p.R158C | P00491 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PNP | SNV | Missense_Mutation | novel | c.819N>T | p.Gln273His | p.Q273H | P00491 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL550755 | FORODESINE HYDROCHLORIDE | |
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | Guanosine | GUANOSINE | ||
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | ULODESINE | ULODESINE | ||
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | FORODESINE | FORODESINE | ||
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | BCX-3408 | ULODESINE | ||
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | 2'3'-Dideoxyinosine | |||
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | FORODESINE HYDROCHLORIDE | FORODESINE HYDROCHLORIDE | 19386496,19386498 | |
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | Peldesine | PELDESINE | ||
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | inhibitor | 252166484 | FORODESINE | |
| 4860 | PNP | ENZYME, DRUGGABLE GENOME | Forodesine | FORODESINE |
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