Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/LARP1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/LARP1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/LARP1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/LARP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/LARP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/LARP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/LARP1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/LARP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/LARP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006446110 | Thyroid | PTC | regulation of translational initiation | 55/5968 | 79/18723 | 6.21e-12 | 2.63e-10 | 55 |
GO:0043487111 | Thyroid | PTC | regulation of RNA stability | 97/5968 | 170/18723 | 9.51e-12 | 3.97e-10 | 97 |
GO:001624110 | Thyroid | PTC | regulation of macroautophagy | 84/5968 | 141/18723 | 1.04e-11 | 4.27e-10 | 84 |
GO:0061013111 | Thyroid | PTC | regulation of mRNA catabolic process | 94/5968 | 166/18723 | 3.55e-11 | 1.29e-09 | 94 |
GO:0043488111 | Thyroid | PTC | regulation of mRNA stability | 90/5968 | 158/18723 | 5.98e-11 | 2.11e-09 | 90 |
GO:0031330113 | Thyroid | PTC | negative regulation of cellular catabolic process | 131/5968 | 262/18723 | 6.63e-10 | 2.03e-08 | 131 |
GO:0009895113 | Thyroid | PTC | negative regulation of catabolic process | 154/5968 | 320/18723 | 7.77e-10 | 2.31e-08 | 154 |
GO:0048524112 | Thyroid | PTC | positive regulation of viral process | 44/5968 | 65/18723 | 3.24e-09 | 8.76e-08 | 44 |
GO:0019079113 | Thyroid | PTC | viral genome replication | 74/5968 | 131/18723 | 4.85e-09 | 1.26e-07 | 74 |
GO:001050810 | Thyroid | PTC | positive regulation of autophagy | 70/5968 | 124/18723 | 1.30e-08 | 3.08e-07 | 70 |
GO:0050792113 | Thyroid | PTC | regulation of viral process | 85/5968 | 164/18723 | 8.33e-08 | 1.70e-06 | 85 |
GO:0042594111 | Thyroid | PTC | response to starvation | 98/5968 | 197/18723 | 1.24e-07 | 2.41e-06 | 98 |
GO:1903312113 | Thyroid | PTC | negative regulation of mRNA metabolic process | 53/5968 | 92/18723 | 3.03e-07 | 5.13e-06 | 53 |
GO:0031667113 | Thyroid | PTC | response to nutrient levels | 201/5968 | 474/18723 | 7.00e-07 | 1.10e-05 | 201 |
GO:003424916 | Thyroid | PTC | negative regulation of cellular amide metabolic process | 122/5968 | 273/18723 | 5.50e-06 | 6.64e-05 | 122 |
GO:1903900113 | Thyroid | PTC | regulation of viral life cycle | 72/5968 | 148/18723 | 1.49e-05 | 1.58e-04 | 72 |
GO:1901654113 | Thyroid | PTC | response to ketone | 90/5968 | 194/18723 | 1.56e-05 | 1.65e-04 | 90 |
GO:00162395 | Thyroid | PTC | positive regulation of macroautophagy | 36/5968 | 63/18723 | 2.98e-05 | 2.86e-04 | 36 |
GO:001714815 | Thyroid | PTC | negative regulation of translation | 108/5968 | 245/18723 | 3.75e-05 | 3.48e-04 | 108 |
GO:0045069112 | Thyroid | PTC | regulation of viral genome replication | 45/5968 | 85/18723 | 4.46e-05 | 4.04e-04 | 45 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LARP1 | SNV | Missense_Mutation | novel | c.1336N>T | p.Arg446Cys | p.R446C | Q6PKG0 | protein_coding | deleterious(0.01) | possibly_damaging(0.707) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
LARP1 | SNV | Missense_Mutation | | c.2636N>T | p.Arg879Leu | p.R879L | Q6PKG0 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
LARP1 | SNV | Missense_Mutation | | c.2360N>T | p.Cys787Phe | p.C787F | Q6PKG0 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LARP1 | SNV | Missense_Mutation | | c.498N>C | p.Gln166His | p.Q166H | Q6PKG0 | protein_coding | tolerated(0.06) | benign(0.048) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LARP1 | SNV | Missense_Mutation | | c.1789N>A | p.Glu597Lys | p.E597K | Q6PKG0 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LARP1 | SNV | Missense_Mutation | rs775862354 | c.253C>T | p.Arg85Cys | p.R85C | Q6PKG0 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LARP1 | SNV | Missense_Mutation | | c.1676N>T | p.Asp559Val | p.D559V | Q6PKG0 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-C8-A12M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LARP1 | SNV | Missense_Mutation | novel | c.238N>A | p.Ala80Thr | p.A80T | Q6PKG0 | protein_coding | tolerated(0.08) | possibly_damaging(0.677) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
LARP1 | insertion | Nonsense_Mutation | novel | c.768_769insTGAAGTC | p.Arg257Ter | p.R257* | Q6PKG0 | protein_coding | | | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LARP1 | insertion | Frame_Shift_Ins | novel | c.815_816insCCCAGAGAGAAACTGGCTTC | p.Arg273ProfsTer38 | p.R273Pfs*38 | Q6PKG0 | protein_coding | | | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |