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Gene: IGF1R |
Gene summary for IGF1R |
Gene summary. |
Gene information | Species | Human | Gene symbol | IGF1R | Gene ID | 3480 |
Gene name | insulin like growth factor 1 receptor | |
Gene Alias | CD221 | |
Cytomap | 15q26.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P08069 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3480 | IGF1R | CA_HPV_1 | Human | Cervix | CC | 5.57e-08 | -2.60e-01 | 0.0264 |
3480 | IGF1R | CCI_1 | Human | Cervix | CC | 2.71e-06 | 1.60e+00 | 0.528 |
3480 | IGF1R | CCI_2 | Human | Cervix | CC | 1.66e-13 | 2.10e+00 | 0.5249 |
3480 | IGF1R | CCI_3 | Human | Cervix | CC | 1.34e-09 | 1.27e+00 | 0.516 |
3480 | IGF1R | H2 | Human | Cervix | HSIL_HPV | 1.31e-02 | 2.27e-01 | 0.0632 |
3480 | IGF1R | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.85e-31 | -7.30e-01 | 0.0155 |
3480 | IGF1R | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.09e-07 | -5.76e-01 | -0.1808 |
3480 | IGF1R | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.99e-03 | -5.93e-01 | 0.0216 |
3480 | IGF1R | HTA11_78_2000001011 | Human | Colorectum | AD | 1.80e-02 | -4.13e-01 | -0.1088 |
3480 | IGF1R | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.42e-09 | -5.80e-01 | -0.1207 |
3480 | IGF1R | HTA11_83_2000001011 | Human | Colorectum | SER | 2.39e-03 | -5.42e-01 | -0.1526 |
3480 | IGF1R | HTA11_696_2000001011 | Human | Colorectum | AD | 1.11e-11 | -4.71e-01 | -0.1464 |
3480 | IGF1R | HTA11_866_2000001011 | Human | Colorectum | AD | 3.15e-04 | -3.85e-01 | -0.1001 |
3480 | IGF1R | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.86e-06 | -4.63e-01 | -0.059 |
3480 | IGF1R | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.10e-04 | -5.55e-01 | -0.1706 |
3480 | IGF1R | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.63e-05 | -7.19e-01 | -0.2061 |
3480 | IGF1R | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.79e-03 | -6.16e-01 | -0.1462 |
3480 | IGF1R | HTA11_866_3004761011 | Human | Colorectum | AD | 1.26e-12 | -5.17e-01 | 0.096 |
3480 | IGF1R | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.48e-05 | -5.40e-01 | 0.0338 |
3480 | IGF1R | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.29e-08 | -4.90e-01 | 0.0674 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007133119 | Thyroid | HT | cellular response to hexose stimulus | 23/1272 | 153/18723 | 2.68e-04 | 3.70e-03 | 23 |
GO:007132220 | Thyroid | HT | cellular response to carbohydrate stimulus | 24/1272 | 163/18723 | 2.74e-04 | 3.75e-03 | 24 |
GO:007132619 | Thyroid | HT | cellular response to monosaccharide stimulus | 23/1272 | 154/18723 | 2.95e-04 | 3.98e-03 | 23 |
GO:00380832 | Thyroid | HT | peptidyl-tyrosine autophosphorylation | 7/1272 | 21/18723 | 3.28e-04 | 4.25e-03 | 7 |
GO:004340925 | Thyroid | HT | negative regulation of MAPK cascade | 25/1272 | 180/18723 | 5.10e-04 | 6.14e-03 | 25 |
GO:003367426 | Thyroid | HT | positive regulation of kinase activity | 51/1272 | 467/18723 | 5.42e-04 | 6.46e-03 | 51 |
GO:00972426 | Thyroid | HT | amyloid-beta clearance | 9/1272 | 38/18723 | 8.09e-04 | 8.78e-03 | 9 |
GO:19908455 | Thyroid | HT | adaptive thermogenesis | 22/1272 | 157/18723 | 9.54e-04 | 9.83e-03 | 22 |
GO:002241123 | Thyroid | HT | cellular component disassembly | 47/1272 | 443/18723 | 1.60e-03 | 1.48e-02 | 47 |
GO:004632816 | Thyroid | HT | regulation of JNK cascade | 19/1272 | 133/18723 | 1.64e-03 | 1.50e-02 | 19 |
GO:00016595 | Thyroid | HT | temperature homeostasis | 23/1272 | 174/18723 | 1.64e-03 | 1.50e-02 | 23 |
GO:01061067 | Thyroid | HT | cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:01201617 | Thyroid | HT | regulation of cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:004505610 | Thyroid | HT | transcytosis | 6/1272 | 21/18723 | 2.17e-03 | 1.88e-02 | 6 |
GO:007137519 | Thyroid | HT | cellular response to peptide hormone stimulus | 33/1272 | 290/18723 | 2.53e-03 | 2.12e-02 | 33 |
GO:003298419 | Thyroid | HT | protein-containing complex disassembly | 27/1272 | 224/18723 | 2.69e-03 | 2.24e-02 | 27 |
GO:004259319 | Thyroid | HT | glucose homeostasis | 30/1272 | 258/18723 | 2.80e-03 | 2.29e-02 | 30 |
GO:003350019 | Thyroid | HT | carbohydrate homeostasis | 30/1272 | 259/18723 | 2.97e-03 | 2.40e-02 | 30 |
GO:000725418 | Thyroid | HT | JNK cascade | 21/1272 | 167/18723 | 4.64e-03 | 3.28e-02 | 21 |
GO:003286920 | Thyroid | HT | cellular response to insulin stimulus | 24/1272 | 203/18723 | 5.72e-03 | 3.72e-02 | 24 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa052148 | Cervix | CC | Glioma | 24/1267 | 75/8465 | 1.51e-04 | 9.20e-04 | 5.44e-04 | 24 |
hsa015223 | Cervix | CC | Endocrine resistance | 28/1267 | 98/8465 | 3.82e-04 | 1.87e-03 | 1.11e-03 | 28 |
hsa052157 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa0522510 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa0406618 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa05224 | Cervix | CC | Breast cancer | 32/1267 | 147/8465 | 1.66e-02 | 4.88e-02 | 2.88e-02 | 32 |
hsa0520517 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0451014 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0521414 | Cervix | CC | Glioma | 24/1267 | 75/8465 | 1.51e-04 | 9.20e-04 | 5.44e-04 | 24 |
hsa0152212 | Cervix | CC | Endocrine resistance | 28/1267 | 98/8465 | 3.82e-04 | 1.87e-03 | 1.11e-03 | 28 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Breast | ADJ |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Breast | DCIS |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Cervix | ADJ |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Cervix | CC |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Cervix | Healthy |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Cervix | Precancer |
IGF1 | IGF1R | IGF1_IGF1R | IGF | CRC | ADJ |
IGF1 | IGF1R | IGF1_IGF1R | IGF | CRC | CRC |
IGF1 | IGF1R | IGF1_IGF1R | IGF | CRC | FAP |
IGF2 | IGF1R | IGF2_IGF1R | IGF | CRC | MSS |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Endometrium | ADJ |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Endometrium | AEH |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Endometrium | EEC |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Endometrium | Healthy |
IGF2 | IGF1R | IGF2_IGF1R | IGF | Endometrium | Healthy |
IGF1 | IGF1R | IGF1_IGF1R | IGF | Esophagus | ESCC |
IGF2 | IGF1R | IGF2_IGF1R | IGF | Esophagus | ESCC |
IGF1 | IGF1R | IGF1_IGF1R | IGF | GC | ADJ |
IGF1 | IGF1R | IGF1_IGF1R | IGF | HNSCC | OSCC |
IGF2 | IGF1R | IGF2_IGF1R | IGF | HNSCC | OSCC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGF1R | SNV | Missense_Mutation | novel | c.899A>G | p.Asp300Gly | p.D300G | P08069 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
IGF1R | SNV | Missense_Mutation | c.199N>T | p.Ala67Ser | p.A67S | P08069 | protein_coding | tolerated(0.14) | benign(0.011) | TCGA-A2-A25C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
IGF1R | SNV | Missense_Mutation | c.55C>G | p.Leu19Val | p.L19V | P08069 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IGF1R | SNV | Missense_Mutation | c.2431G>C | p.Glu811Gln | p.E811Q | P08069 | protein_coding | tolerated(0.7) | benign(0.001) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IGF1R | SNV | Missense_Mutation | novel | c.3131G>T | p.Arg1044Met | p.R1044M | P08069 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGF1R | SNV | Missense_Mutation | c.1099N>T | p.Gly367Trp | p.G367W | P08069 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IGF1R | SNV | Missense_Mutation | c.3003N>A | p.Met1001Ile | p.M1001I | P08069 | protein_coding | tolerated(0.44) | benign(0.007) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
IGF1R | SNV | Missense_Mutation | novel | c.2026N>T | p.Gly676Cys | p.G676C | P08069 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
IGF1R | SNV | Missense_Mutation | c.1828G>A | p.Val610Ile | p.V610I | P08069 | protein_coding | tolerated(0.09) | benign(0.009) | TCGA-BH-A0C3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | |
IGF1R | SNV | Missense_Mutation | novel | c.3938C>T | p.Ser1313Phe | p.S1313F | P08069 | protein_coding | tolerated(0.06) | possibly_damaging(0.474) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | OSI-906 | LINSITINIB | ||
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | antibody | AMG-479 | GANITUMAB | |
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | VPI-2690B | |||
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | Somatomedin-1 | |||
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | SB-202190 | SB-202190 | ||
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | antibody | GANITUMAB | GANITUMAB | |
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | antibody | FIGITUMUMAB | FIGITUMUMAB | |
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | antibody | 310264711 | ISTIRATUMAB | |
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | TT-100 | |||
3480 | IGF1R | DRUGGABLE GENOME, KINASE, CLINICALLY ACTIONABLE, TYROSINE KINASE | agonist | CHEMBL1201716 | MECASERMIN |
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