GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
GO:00328692 | Colorectum | MSS | cellular response to insulin stimulus | 56/3467 | 203/18723 | 9.41e-04 | 9.50e-03 | 56 |
GO:19017962 | Colorectum | MSS | regulation of signal transduction by p53 class mediator | 30/3467 | 93/18723 | 1.03e-03 | 1.02e-02 | 30 |
GO:00719021 | Colorectum | MSS | positive regulation of protein serine/threonine kinase activity | 55/3467 | 200/18723 | 1.12e-03 | 1.11e-02 | 55 |
GO:00713752 | Colorectum | MSS | cellular response to peptide hormone stimulus | 75/3467 | 290/18723 | 1.14e-03 | 1.12e-02 | 75 |
GO:00335221 | Colorectum | MSS | histone H2A ubiquitination | 12/3467 | 26/18723 | 1.16e-03 | 1.12e-02 | 12 |
GO:00017312 | Colorectum | MSS | formation of translation preinitiation complex | 7/3467 | 11/18723 | 1.21e-03 | 1.17e-02 | 7 |
GO:00900872 | Colorectum | MSS | regulation of peptide transport | 55/3467 | 202/18723 | 1.44e-03 | 1.34e-02 | 55 |
GO:00902572 | Colorectum | MSS | regulation of muscle system process | 66/3467 | 252/18723 | 1.55e-03 | 1.41e-02 | 66 |
GO:00064461 | Colorectum | MSS | regulation of translational initiation | 26/3467 | 79/18723 | 1.56e-03 | 1.42e-02 | 26 |
GO:01200322 | Colorectum | MSS | regulation of plasma membrane bounded cell projection assembly | 51/3467 | 186/18723 | 1.78e-03 | 1.58e-02 | 51 |
GO:0051090 | Colorectum | MSS | regulation of DNA-binding transcription factor activity | 106/3467 | 440/18723 | 1.88e-03 | 1.65e-02 | 106 |
GO:00097912 | Colorectum | MSS | post-embryonic development | 26/3467 | 80/18723 | 1.91e-03 | 1.66e-02 | 26 |
GO:00311001 | Colorectum | MSS | animal organ regeneration | 25/3467 | 76/18723 | 1.91e-03 | 1.66e-02 | 25 |
GO:00027912 | Colorectum | MSS | regulation of peptide secretion | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
GO:00300721 | Colorectum | MSS | peptide hormone secretion | 62/3467 | 236/18723 | 1.95e-03 | 1.68e-02 | 62 |
GO:00310322 | Colorectum | MSS | actomyosin structure organization | 53/3467 | 196/18723 | 2.04e-03 | 1.75e-02 | 53 |
GO:00902762 | Colorectum | MSS | regulation of peptide hormone secretion | 53/3467 | 196/18723 | 2.04e-03 | 1.75e-02 | 53 |
GO:00324091 | Colorectum | MSS | regulation of transporter activity | 78/3467 | 310/18723 | 2.09e-03 | 1.78e-02 | 78 |
GO:00328682 | Colorectum | MSS | response to insulin | 68/3467 | 264/18723 | 2.10e-03 | 1.78e-02 | 68 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F5 | SNV | Missense_Mutation | novel | c.4241N>T | p.Asp1414Val | p.D1414V | P12259 | protein_coding | deleterious_low_confidence(0.04) | benign(0.209) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | novel | c.3913N>G | p.Pro1305Ala | p.P1305A | P12259 | protein_coding | deleterious_low_confidence(0.03) | benign(0.265) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | novel | c.1495C>A | p.Gln499Lys | p.Q499K | P12259 | protein_coding | deleterious(0.02) | possibly_damaging(0.541) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
F5 | SNV | Missense_Mutation | | c.6397N>T | p.Ile2133Leu | p.I2133L | P12259 | protein_coding | deleterious(0.02) | possibly_damaging(0.622) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | | c.6396N>T | p.Lys2132Asn | p.K2132N | P12259 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | | CR |
F5 | SNV | Missense_Mutation | novel | c.4087N>A | p.His1363Asn | p.H1363N | P12259 | protein_coding | tolerated_low_confidence(0.14) | benign(0.023) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | novel | c.4086N>A | p.Ser1362Arg | p.S1362R | P12259 | protein_coding | tolerated_low_confidence(0.09) | benign(0.168) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | | c.622G>C | p.Asp208His | p.D208H | P12259 | protein_coding | tolerated(0.13) | benign(0.123) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | | c.1447N>A | p.Tyr483Asn | p.Y483N | P12259 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
F5 | SNV | Missense_Mutation | novel | c.5676N>C | p.Gln1892His | p.Q1892H | P12259 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2153 | F5 | DRUGGABLE GENOME | | drotrecogin alfa | | 15118525 |
2153 | F5 | DRUGGABLE GENOME | | rivaroxaban | RIVAROXABAN | |
2153 | F5 | DRUGGABLE GENOME | | Rivaroxaban | RIVAROXABAN | |
2153 | F5 | DRUGGABLE GENOME | | estrogens | ESTRONE SODIUM SULFATE | 11532625,16113779,12067913,12869355,16301339,9459317,10073976,15467059,11859850,10943572,12069454,12138364,14551147,7968118,11703344 |
2153 | F5 | DRUGGABLE GENOME | | Drotrecogin alfa | | |
2153 | F5 | DRUGGABLE GENOME | | Eltrombopag | ELTROMBOPAG | |
2153 | F5 | DRUGGABLE GENOME | | DROTRECOGIN ALFA | | |
2153 | F5 | DRUGGABLE GENOME | | hormonal contraceptives for systemic use | | 11532625,16113779,15208046,15946211,12869355,16301339,9459317,10073976,15467059,11859850,10943572,12069454,16769590,12138364,14551147,7968118 |
2153 | F5 | DRUGGABLE GENOME | inhibitor | CHEMBL2109065 | DROTRECOGIN ALFA (ACTIVATED) | |
2153 | F5 | DRUGGABLE GENOME | | THROMBIN | THROMBIN | |