Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/ENO1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ENO1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ENO1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ENO1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ENO1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ENO1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/ENO1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ENO1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ENO1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ENO1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ENO1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ENO1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ENO1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603114 | Endometrium | EEC | ADP metabolic process | 22/2168 | 90/18723 | 4.82e-04 | 4.94e-03 | 22 |
GO:190357816 | Endometrium | EEC | regulation of ATP metabolic process | 21/2168 | 87/18723 | 7.66e-04 | 7.16e-03 | 21 |
GO:00303081 | Endometrium | EEC | negative regulation of cell growth | 37/2168 | 188/18723 | 8.33e-04 | 7.67e-03 | 37 |
GO:000911716 | Endometrium | EEC | nucleotide metabolic process | 80/2168 | 489/18723 | 8.65e-04 | 7.95e-03 | 80 |
GO:000926015 | Endometrium | EEC | ribonucleotide biosynthetic process | 36/2168 | 182/18723 | 8.83e-04 | 8.03e-03 | 36 |
GO:004639015 | Endometrium | EEC | ribose phosphate biosynthetic process | 37/2168 | 190/18723 | 1.02e-03 | 8.98e-03 | 37 |
GO:000675315 | Endometrium | EEC | nucleoside phosphate metabolic process | 80/2168 | 497/18723 | 1.39e-03 | 1.14e-02 | 80 |
GO:00069361 | Endometrium | EEC | muscle contraction | 59/2168 | 347/18723 | 1.57e-03 | 1.26e-02 | 59 |
GO:007145314 | Endometrium | EEC | cellular response to oxygen levels | 34/2168 | 177/18723 | 2.02e-03 | 1.53e-02 | 34 |
GO:000616414 | Endometrium | EEC | purine nucleotide biosynthetic process | 36/2168 | 191/18723 | 2.14e-03 | 1.61e-02 | 36 |
GO:007252214 | Endometrium | EEC | purine-containing compound biosynthetic process | 37/2168 | 200/18723 | 2.62e-03 | 1.90e-02 | 37 |
GO:009025712 | Endometrium | EEC | regulation of muscle system process | 44/2168 | 252/18723 | 3.51e-03 | 2.36e-02 | 44 |
GO:000609014 | Endometrium | EEC | pyruvate metabolic process | 22/2168 | 106/18723 | 4.53e-03 | 2.92e-02 | 22 |
GO:003629414 | Endometrium | EEC | cellular response to decreased oxygen levels | 30/2168 | 161/18723 | 5.66e-03 | 3.40e-02 | 30 |
GO:000693711 | Endometrium | EEC | regulation of muscle contraction | 31/2168 | 169/18723 | 6.29e-03 | 3.71e-02 | 31 |
GO:00091656 | Endometrium | EEC | nucleotide biosynthetic process | 43/2168 | 254/18723 | 6.79e-03 | 3.95e-02 | 43 |
GO:19012936 | Endometrium | EEC | nucleoside phosphate biosynthetic process | 43/2168 | 256/18723 | 7.79e-03 | 4.34e-02 | 43 |
GO:00714567 | Endometrium | EEC | cellular response to hypoxia | 28/2168 | 151/18723 | 7.84e-03 | 4.36e-02 | 28 |
GO:004603427 | Esophagus | HGIN | ATP metabolic process | 101/2587 | 277/18723 | 1.53e-21 | 1.02e-18 | 101 |
GO:000609120 | Esophagus | HGIN | generation of precursor metabolites and energy | 145/2587 | 490/18723 | 3.41e-20 | 2.04e-17 | 145 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENO1 | SNV | Missense_Mutation | | c.689C>A | p.Ala230Asp | p.A230D | P06733 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.988) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
ENO1 | SNV | Missense_Mutation | rs750183904 | c.466N>A | p.Gly156Ser | p.G156S | P06733 | protein_coding | deleterious_low_confidence(0.05) | possibly_damaging(0.594) | TCGA-E9-A22H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ENO1 | insertion | Nonsense_Mutation | novel | c.945_946insATTTTATTTTTATTTTTTTGAGAGGGATCTCACTC | p.Val316IlefsTer7 | p.V316Ifs*7 | P06733 | protein_coding | | | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
ENO1 | SNV | Missense_Mutation | | c.1240G>A | p.Glu414Lys | p.E414K | P06733 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.984) | TCGA-C5-A7CH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | | SD |
ENO1 | SNV | Missense_Mutation | rs527568599 | c.452N>G | p.Asn151Ser | p.N151S | P06733 | protein_coding | deleterious_low_confidence(0.05) | benign(0.083) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENO1 | SNV | Missense_Mutation | novel | c.628N>A | p.Glu210Lys | p.E210K | P06733 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.796) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENO1 | insertion | Frame_Shift_Ins | novel | c.1081dupC | p.Gln361ProfsTer17 | p.Q361Pfs*17 | P06733 | protein_coding | | | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENO1 | SNV | Missense_Mutation | novel | c.97G>C | p.Ala33Pro | p.A33P | P06733 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
ENO1 | SNV | Missense_Mutation | | c.223C>G | p.Pro75Ala | p.P75A | P06733 | protein_coding | deleterious_low_confidence(0.03) | benign(0.046) | TCGA-AD-6965-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
ENO1 | SNV | Missense_Mutation | | c.1286G>A | p.Arg429Lys | p.R429K | P06733 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.861) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |