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Gene: CHMP3 |
Gene summary for CHMP3 |
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Gene information | Species | Human | Gene symbol | CHMP3 | Gene ID | 51652 |
Gene name | charged multivesicular body protein 3 | |
Gene Alias | CGI-149 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9Y3E7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51652 | CHMP3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.05e-34 | 7.46e-01 | 0.0155 |
51652 | CHMP3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.00e-31 | 1.08e+00 | -0.1808 |
51652 | CHMP3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.69e-05 | 6.60e-01 | 0.0216 |
51652 | CHMP3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.72e-33 | 1.28e+00 | -0.0811 |
51652 | CHMP3 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.39e-32 | 1.23e+00 | -0.1088 |
51652 | CHMP3 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.07e-65 | 1.44e+00 | -0.1954 |
51652 | CHMP3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.06e-10 | 1.62e+00 | -0.2602 |
51652 | CHMP3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.10e-10 | 1.14e+00 | -0.2196 |
51652 | CHMP3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.00e-13 | 7.38e-01 | -0.1207 |
51652 | CHMP3 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.73e-22 | 1.19e+00 | -0.1526 |
51652 | CHMP3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.06e-52 | 9.70e-01 | -0.1464 |
51652 | CHMP3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.05e-36 | 7.79e-01 | -0.1001 |
51652 | CHMP3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.53e-38 | 1.20e+00 | -0.059 |
51652 | CHMP3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.13e-21 | 1.28e+00 | -0.1706 |
51652 | CHMP3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.27e-21 | 1.24e+00 | -0.2061 |
51652 | CHMP3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 5.68e-14 | 1.01e+00 | -0.1462 |
51652 | CHMP3 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.50e-17 | 9.44e-01 | -0.0842 |
51652 | CHMP3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.60e-04 | 7.17e-01 | -0.00410000000000005 |
51652 | CHMP3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.84e-11 | 7.75e-01 | -0.0179 |
51652 | CHMP3 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.36e-24 | 8.07e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003250916 | Thyroid | PTC | endosome transport via multivesicular body sorting pathway | 26/5968 | 31/18723 | 3.25e-09 | 8.76e-08 | 26 |
GO:00362579 | Thyroid | PTC | multivesicular body organization | 26/5968 | 31/18723 | 3.25e-09 | 8.76e-08 | 26 |
GO:00362588 | Thyroid | PTC | multivesicular body assembly | 25/5968 | 30/18723 | 8.60e-09 | 2.10e-07 | 25 |
GO:0052126113 | Thyroid | PTC | movement in host environment | 91/5968 | 175/18723 | 2.41e-08 | 5.43e-07 | 91 |
GO:0050792113 | Thyroid | PTC | regulation of viral process | 85/5968 | 164/18723 | 8.33e-08 | 1.70e-06 | 85 |
GO:004578718 | Thyroid | PTC | positive regulation of cell cycle | 144/5968 | 313/18723 | 9.93e-08 | 1.99e-06 | 144 |
GO:000704115 | Thyroid | PTC | lysosomal transport | 63/5968 | 114/18723 | 1.97e-07 | 3.54e-06 | 63 |
GO:00719858 | Thyroid | PTC | multivesicular body sorting pathway | 27/5968 | 37/18723 | 3.42e-07 | 5.75e-06 | 27 |
GO:000703210 | Thyroid | PTC | endosome organization | 48/5968 | 82/18723 | 5.65e-07 | 9.04e-06 | 48 |
GO:00002818 | Thyroid | PTC | mitotic cytokinesis | 43/5968 | 71/18723 | 5.93e-07 | 9.47e-06 | 43 |
GO:00482846 | Thyroid | PTC | organelle fusion | 71/5968 | 141/18723 | 3.68e-06 | 4.70e-05 | 71 |
GO:004532414 | Thyroid | PTC | late endosome to vacuole transport | 19/5968 | 25/18723 | 7.43e-06 | 8.65e-05 | 19 |
GO:001906816 | Thyroid | PTC | virion assembly | 24/5968 | 35/18723 | 9.08e-06 | 1.03e-04 | 24 |
GO:000091019 | Thyroid | PTC | cytokinesis | 82/5968 | 173/18723 | 1.37e-05 | 1.47e-04 | 82 |
GO:1903900113 | Thyroid | PTC | regulation of viral life cycle | 72/5968 | 148/18723 | 1.49e-05 | 1.58e-04 | 72 |
GO:00610256 | Thyroid | PTC | membrane fusion | 77/5968 | 163/18723 | 2.86e-05 | 2.78e-04 | 77 |
GO:00069065 | Thyroid | PTC | vesicle fusion | 54/5968 | 106/18723 | 3.39e-05 | 3.21e-04 | 54 |
GO:00325068 | Thyroid | PTC | cytokinetic process | 25/5968 | 39/18723 | 3.50e-05 | 3.30e-04 | 25 |
GO:00397029 | Thyroid | PTC | viral budding via host ESCRT complex | 16/5968 | 21/18723 | 3.87e-05 | 3.56e-04 | 16 |
GO:190241010 | Thyroid | PTC | mitotic cytokinetic process | 17/5968 | 23/18723 | 4.25e-05 | 3.87e-04 | 17 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP3 | SNV | Missense_Mutation | c.83N>A | p.Arg28Lys | p.R28K | Q9Y3E7 | protein_coding | deleterious(0.02) | benign(0.146) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
CHMP3 | insertion | In_Frame_Ins | novel | c.11_12insCCCACATCTCAGCTCTGTGATCTC | p.Phe4_Gly5insProHisLeuSerSerValIleSer | p.F4_G5insPHLSSVIS | Q9Y3E7 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
CHMP3 | SNV | Missense_Mutation | c.83N>A | p.Arg28Lys | p.R28K | Q9Y3E7 | protein_coding | deleterious(0.02) | benign(0.146) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CHMP3 | SNV | Missense_Mutation | rs368950086 | c.287N>T | p.Ala96Val | p.A96V | Q9Y3E7 | protein_coding | deleterious(0.03) | possibly_damaging(0.858) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHMP3 | SNV | Missense_Mutation | novel | c.554C>A | p.Thr185Asn | p.T185N | Q9Y3E7 | protein_coding | deleterious(0.04) | possibly_damaging(0.817) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP3 | SNV | Missense_Mutation | novel | c.63N>T | p.Leu21Phe | p.L21F | Q9Y3E7 | protein_coding | tolerated(0.7) | benign(0.138) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP3 | SNV | Missense_Mutation | c.466N>A | p.Glu156Lys | p.E156K | Q9Y3E7 | protein_coding | deleterious(0.04) | benign(0.195) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CHMP3 | SNV | Missense_Mutation | novel | c.201N>T | p.Met67Ile | p.M67I | Q9Y3E7 | protein_coding | tolerated(1) | benign(0.003) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP3 | SNV | Missense_Mutation | novel | c.337N>A | p.Ala113Thr | p.A113T | Q9Y3E7 | protein_coding | tolerated(0.05) | benign(0.222) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP3 | SNV | Missense_Mutation | novel | c.578C>A | p.Pro193His | p.P193H | Q9Y3E7 | protein_coding | deleterious(0.03) | benign(0.379) | TCGA-56-8629-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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