Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/ACTG1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ACTG1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ACTG1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ACTG1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ACTG1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ACTG1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/ACTG1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ACTG1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ACTG1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ACTG1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ACTG1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ACTG1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ACTG1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004314913 | Lung | AIS | stress fiber assembly | 26/1849 | 106/18723 | 9.56e-06 | 4.06e-04 | 26 |
GO:000173811 | Lung | AIS | morphogenesis of a polarized epithelium | 24/1849 | 94/18723 | 1.00e-05 | 4.18e-04 | 24 |
GO:011005313 | Lung | AIS | regulation of actin filament organization | 50/1849 | 278/18723 | 2.13e-05 | 7.27e-04 | 50 |
GO:003223113 | Lung | AIS | regulation of actin filament bundle assembly | 25/1849 | 105/18723 | 2.43e-05 | 8.01e-04 | 25 |
GO:000704313 | Lung | AIS | cell-cell junction assembly | 31/1849 | 146/18723 | 3.18e-05 | 1.01e-03 | 31 |
GO:009950411 | Lung | AIS | synaptic vesicle cycle | 36/1849 | 181/18723 | 3.42e-05 | 1.05e-03 | 36 |
GO:005149213 | Lung | AIS | regulation of stress fiber assembly | 22/1849 | 91/18723 | 5.73e-05 | 1.60e-03 | 22 |
GO:004848811 | Lung | AIS | synaptic vesicle endocytosis | 17/1849 | 62/18723 | 7.32e-05 | 1.91e-03 | 17 |
GO:014023811 | Lung | AIS | presynaptic endocytosis | 17/1849 | 62/18723 | 7.32e-05 | 1.91e-03 | 17 |
GO:012019312 | Lung | AIS | tight junction organization | 20/1849 | 80/18723 | 7.41e-05 | 1.93e-03 | 20 |
GO:012019212 | Lung | AIS | tight junction assembly | 19/1849 | 74/18723 | 7.55e-05 | 1.94e-03 | 19 |
GO:011002013 | Lung | AIS | regulation of actomyosin structure organization | 23/1849 | 100/18723 | 8.99e-05 | 2.21e-03 | 23 |
GO:003646511 | Lung | AIS | synaptic vesicle recycling | 18/1849 | 75/18723 | 2.89e-04 | 5.40e-03 | 18 |
GO:009917311 | Lung | AIS | postsynapse organization | 31/1849 | 168/18723 | 4.67e-04 | 7.79e-03 | 31 |
GO:015010512 | Lung | AIS | protein localization to cell-cell junction | 8/1849 | 21/18723 | 5.58e-04 | 8.73e-03 | 8 |
GO:00426921 | Lung | AIS | muscle cell differentiation | 58/1849 | 384/18723 | 7.00e-04 | 1.03e-02 | 58 |
GO:005080811 | Lung | AIS | synapse organization | 63/1849 | 426/18723 | 7.39e-04 | 1.07e-02 | 63 |
GO:00508788 | Lung | AIS | regulation of body fluid levels | 57/1849 | 379/18723 | 8.60e-04 | 1.17e-02 | 57 |
GO:003563312 | Lung | AIS | maintenance of blood-brain barrier | 10/1849 | 35/18723 | 1.57e-03 | 1.83e-02 | 10 |
GO:000189412 | Lung | AIS | tissue homeostasis | 41/1849 | 268/18723 | 3.13e-03 | 3.01e-02 | 41 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTG1 | SNV | Missense_Mutation | novel | c.83G>T | p.Arg28Leu | p.R28L | P63261 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
ACTG1 | SNV | Missense_Mutation | novel | c.356N>C | p.Met119Thr | p.M119T | P63261 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.969) | TCGA-AC-A3QP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ACTG1 | SNV | Missense_Mutation | novel | c.242N>G | p.Asp81Gly | p.D81G | P63261 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-C8-A3M8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
ACTG1 | SNV | Missense_Mutation | | c.727C>G | p.Pro243Ala | p.P243A | P63261 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.951) | TCGA-D8-A146-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACTG1 | SNV | Missense_Mutation | | c.614N>G | p.Glu205Gly | p.E205G | P63261 | protein_coding | deleterious_low_confidence(0.01) | benign(0.201) | TCGA-E2-A1LS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cyclophosphamide | SD |
ACTG1 | insertion | Nonsense_Mutation | novel | c.170_171insTGCACACACCTCATGCTAGCCTCACGAAACT | p.Glu57AspfsTer7 | p.E57Dfs*7 | P63261 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACTG1 | insertion | Frame_Shift_Ins | novel | c.379_380insCCCCCACGCCATCCTGCGTCTG | p.Phe127SerfsTer76 | p.F127Sfs*76 | P63261 | protein_coding | | | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ACTG1 | insertion | Frame_Shift_Ins | novel | c.983_984insCGTGCTTGTGGAAGACAAGTCTGTGGCTT | p.Lys328AsnfsTer11 | p.K328Nfs*11 | P63261 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ACTG1 | SNV | Missense_Mutation | novel | c.965N>T | p.Pro322Leu | p.P322L | P63261 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.466) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACTG1 | SNV | Missense_Mutation | | c.757N>A | p.Glu253Lys | p.E253K | P63261 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.999) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |