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Gene: TTL |
Gene summary for TTL |
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Gene information | Species | Human | Gene symbol | TTL | Gene ID | 150465 |
Gene name | tubulin tyrosine ligase | |
Gene Alias | TTL | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8NG68 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150465 | TTL | HCC1_Meng | Human | Liver | HCC | 2.30e-18 | 1.76e-02 | 0.0246 |
150465 | TTL | HCC2 | Human | Liver | HCC | 9.58e-20 | 3.89e+00 | 0.5341 |
150465 | TTL | Pt14.a | Human | Liver | HCC | 2.24e-03 | 2.59e-01 | 0.0169 |
150465 | TTL | S014 | Human | Liver | HCC | 1.02e-03 | 2.53e-01 | 0.2254 |
150465 | TTL | S016 | Human | Liver | HCC | 1.25e-02 | 1.97e-01 | 0.2243 |
150465 | TTL | S028 | Human | Liver | HCC | 1.53e-16 | 5.89e-01 | 0.2503 |
150465 | TTL | S029 | Human | Liver | HCC | 2.40e-10 | 5.72e-01 | 0.2581 |
150465 | TTL | C04 | Human | Oral cavity | OSCC | 1.01e-08 | 6.21e-01 | 0.2633 |
150465 | TTL | C21 | Human | Oral cavity | OSCC | 4.49e-08 | 3.48e-01 | 0.2678 |
150465 | TTL | C30 | Human | Oral cavity | OSCC | 6.89e-11 | 5.60e-01 | 0.3055 |
150465 | TTL | C38 | Human | Oral cavity | OSCC | 8.98e-05 | 5.37e-01 | 0.172 |
150465 | TTL | C46 | Human | Oral cavity | OSCC | 2.38e-02 | 1.46e-01 | 0.1673 |
150465 | TTL | C51 | Human | Oral cavity | OSCC | 8.78e-04 | 2.58e-01 | 0.2674 |
150465 | TTL | C09 | Human | Oral cavity | OSCC | 3.48e-02 | 9.74e-02 | 0.1431 |
150465 | TTL | SYSMH1 | Human | Oral cavity | OSCC | 5.30e-08 | 2.88e-01 | 0.1127 |
150465 | TTL | SYSMH2 | Human | Oral cavity | OSCC | 3.78e-09 | 3.36e-01 | 0.2326 |
150465 | TTL | SYSMH3 | Human | Oral cavity | OSCC | 3.60e-23 | 5.98e-01 | 0.2442 |
150465 | TTL | male-WTA | Human | Thyroid | PTC | 2.21e-14 | 1.64e-01 | 0.1037 |
150465 | TTL | PTC01 | Human | Thyroid | PTC | 1.95e-02 | 3.73e-02 | 0.1899 |
150465 | TTL | PTC04 | Human | Thyroid | PTC | 1.89e-05 | 1.61e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
GO:003424916 | Thyroid | PTC | negative regulation of cellular amide metabolic process | 122/5968 | 273/18723 | 5.50e-06 | 6.64e-05 | 122 |
GO:004858819 | Thyroid | PTC | developmental cell growth | 106/5968 | 234/18723 | 1.07e-05 | 1.19e-04 | 106 |
GO:006056018 | Thyroid | PTC | developmental growth involved in morphogenesis | 105/5968 | 234/18723 | 1.94e-05 | 1.98e-04 | 105 |
GO:199013817 | Thyroid | PTC | neuron projection extension | 81/5968 | 172/18723 | 2.07e-05 | 2.08e-04 | 81 |
GO:00070595 | Thyroid | PTC | chromosome segregation | 146/5968 | 346/18723 | 2.99e-05 | 2.87e-04 | 146 |
GO:001714815 | Thyroid | PTC | negative regulation of translation | 108/5968 | 245/18723 | 3.75e-05 | 3.48e-04 | 108 |
GO:000836115 | Thyroid | PTC | regulation of cell size | 83/5968 | 181/18723 | 5.45e-05 | 4.84e-04 | 83 |
GO:009872710 | Thyroid | PTC | maintenance of cell number | 63/5968 | 134/18723 | 1.73e-04 | 1.32e-03 | 63 |
GO:00305167 | Thyroid | PTC | regulation of axon extension | 47/5968 | 95/18723 | 2.60e-04 | 1.86e-03 | 47 |
GO:00198279 | Thyroid | PTC | stem cell population maintenance | 61/5968 | 131/18723 | 3.01e-04 | 2.12e-03 | 61 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:00613873 | Thyroid | PTC | regulation of extent of cell growth | 52/5968 | 110/18723 | 5.20e-04 | 3.37e-03 | 52 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
GO:00988135 | Thyroid | PTC | nuclear chromosome segregation | 114/5968 | 281/18723 | 1.21e-03 | 6.94e-03 | 114 |
GO:004206315 | Thyroid | PTC | gliogenesis | 121/5968 | 301/18723 | 1.30e-03 | 7.41e-03 | 121 |
GO:00500005 | Thyroid | PTC | chromosome localization | 39/5968 | 82/18723 | 2.14e-03 | 1.14e-02 | 39 |
GO:00513035 | Thyroid | PTC | establishment of chromosome localization | 38/5968 | 80/18723 | 2.49e-03 | 1.29e-02 | 38 |
GO:00513105 | Thyroid | PTC | metaphase plate congression | 32/5968 | 65/18723 | 2.62e-03 | 1.34e-02 | 32 |
GO:004886318 | Thyroid | PTC | stem cell differentiation | 85/5968 | 206/18723 | 2.71e-03 | 1.36e-02 | 85 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTL | SNV | Missense_Mutation | c.971N>G | p.Glu324Gly | p.E324G | Q8NG68 | protein_coding | tolerated(0.16) | benign(0.026) | TCGA-B6-A0IC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTL | SNV | Missense_Mutation | novel | c.131G>T | p.Arg44Met | p.R44M | Q8NG68 | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TTL | SNV | Missense_Mutation | novel | c.968A>G | p.Glu323Gly | p.E323G | Q8NG68 | protein_coding | deleterious(0.04) | benign(0.093) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TTL | SNV | Missense_Mutation | rs746535633 | c.279N>T | p.Trp93Cys | p.W93C | Q8NG68 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TTL | SNV | Missense_Mutation | c.217N>T | p.Arg73Cys | p.R73C | Q8NG68 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TTL | SNV | Missense_Mutation | c.414G>T | p.Lys138Asn | p.K138N | Q8NG68 | protein_coding | tolerated(0.13) | benign(0.163) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TTL | SNV | Missense_Mutation | novel | c.661N>A | p.Leu221Ile | p.L221I | Q8NG68 | protein_coding | deleterious(0.03) | possibly_damaging(0.883) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TTL | SNV | Missense_Mutation | c.170N>T | p.Gly57Val | p.G57V | Q8NG68 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTL | SNV | Missense_Mutation | c.679C>A | p.Pro227Thr | p.P227T | Q8NG68 | protein_coding | deleterious(0.02) | possibly_damaging(0.575) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTL | SNV | Missense_Mutation | rs780073175 | c.218N>A | p.Arg73His | p.R73H | Q8NG68 | protein_coding | deleterious(0.02) | probably_damaging(0.925) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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