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Gene: TGFB2 |
Gene summary for TGFB2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TGFB2 | Gene ID | 7042 |
Gene name | transforming growth factor beta 2 | |
Gene Alias | G-TSF | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P61812 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7042 | TGFB2 | HCC2 | Human | Liver | HCC | 1.20e-24 | 8.34e-01 | 0.5341 |
7042 | TGFB2 | HCC5 | Human | Liver | HCC | 2.87e-30 | 1.03e+00 | 0.4932 |
7042 | TGFB2 | S014 | Human | Liver | HCC | 1.24e-07 | 5.76e-01 | 0.2254 |
7042 | TGFB2 | S016 | Human | Liver | HCC | 4.57e-05 | 4.60e-01 | 0.2243 |
7042 | TGFB2 | S028 | Human | Liver | HCC | 5.88e-08 | 5.46e-01 | 0.2503 |
7042 | TGFB2 | C04 | Human | Oral cavity | OSCC | 3.43e-05 | 4.13e-01 | 0.2633 |
7042 | TGFB2 | C30 | Human | Oral cavity | OSCC | 4.30e-08 | 5.33e-01 | 0.3055 |
7042 | TGFB2 | C09 | Human | Oral cavity | OSCC | 1.71e-17 | 5.78e-01 | 0.1431 |
7042 | TGFB2 | SYSMH3 | Human | Oral cavity | OSCC | 1.06e-03 | 2.44e-01 | 0.2442 |
7042 | TGFB2 | male-WTA | Human | Thyroid | PTC | 2.57e-05 | 8.51e-02 | 0.1037 |
7042 | TGFB2 | PTC01 | Human | Thyroid | PTC | 1.57e-02 | 9.07e-02 | 0.1899 |
7042 | TGFB2 | PTC05 | Human | Thyroid | PTC | 2.55e-02 | 2.04e-01 | 0.2065 |
7042 | TGFB2 | PTC06 | Human | Thyroid | PTC | 2.44e-03 | 1.64e-01 | 0.2057 |
7042 | TGFB2 | PTC07 | Human | Thyroid | PTC | 1.02e-18 | 4.17e-01 | 0.2044 |
7042 | TGFB2 | ATC13 | Human | Thyroid | ATC | 6.16e-27 | 4.38e-01 | 0.34 |
7042 | TGFB2 | ATC2 | Human | Thyroid | ATC | 4.80e-21 | 1.61e+00 | 0.34 |
7042 | TGFB2 | ATC5 | Human | Thyroid | ATC | 1.93e-22 | 4.71e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000323111 | Thyroid | ATC | cardiac ventricle development | 58/6293 | 123/18723 | 1.23e-03 | 6.46e-03 | 58 |
GO:000320612 | Thyroid | ATC | cardiac chamber morphogenesis | 57/6293 | 121/18723 | 1.39e-03 | 7.20e-03 | 57 |
GO:000840613 | Thyroid | ATC | gonad development | 96/6293 | 221/18723 | 1.40e-03 | 7.25e-03 | 96 |
GO:004658012 | Thyroid | ATC | negative regulation of Ras protein signal transduction | 27/6293 | 49/18723 | 1.58e-03 | 7.99e-03 | 27 |
GO:005134629 | Thyroid | ATC | negative regulation of hydrolase activity | 155/6293 | 379/18723 | 1.64e-03 | 8.23e-03 | 155 |
GO:006041111 | Thyroid | ATC | cardiac septum morphogenesis | 35/6293 | 68/18723 | 1.76e-03 | 8.71e-03 | 35 |
GO:19048882 | Thyroid | ATC | cranial skeletal system development | 35/6293 | 68/18723 | 1.76e-03 | 8.71e-03 | 35 |
GO:00457657 | Thyroid | ATC | regulation of angiogenesis | 141/6293 | 342/18723 | 1.80e-03 | 8.85e-03 | 141 |
GO:00600211 | Thyroid | ATC | roof of mouth development | 42/6293 | 85/18723 | 1.83e-03 | 9.02e-03 | 42 |
GO:19013427 | Thyroid | ATC | regulation of vasculature development | 143/6293 | 348/18723 | 1.95e-03 | 9.44e-03 | 143 |
GO:00608401 | Thyroid | ATC | artery development | 48/6293 | 100/18723 | 1.97e-03 | 9.52e-03 | 48 |
GO:0003197 | Thyroid | ATC | endocardial cushion development | 25/6293 | 45/18723 | 2.00e-03 | 9.59e-03 | 25 |
GO:0003203 | Thyroid | ATC | endocardial cushion morphogenesis | 21/6293 | 36/18723 | 2.01e-03 | 9.59e-03 | 21 |
GO:0010934 | Thyroid | ATC | macrophage cytokine production | 12/6293 | 17/18723 | 2.02e-03 | 9.60e-03 | 12 |
GO:0010935 | Thyroid | ATC | regulation of macrophage cytokine production | 12/6293 | 17/18723 | 2.02e-03 | 9.60e-03 | 12 |
GO:003030719 | Thyroid | ATC | positive regulation of cell growth | 74/6293 | 166/18723 | 2.06e-03 | 9.73e-03 | 74 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:00351074 | Thyroid | ATC | appendage morphogenesis | 63/6293 | 138/18723 | 2.13e-03 | 1.00e-02 | 63 |
GO:00351084 | Thyroid | ATC | limb morphogenesis | 63/6293 | 138/18723 | 2.13e-03 | 1.00e-02 | 63 |
GO:003505111 | Thyroid | ATC | cardiocyte differentiation | 70/6293 | 156/18723 | 2.18e-03 | 1.02e-02 | 70 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa052258 | Liver | HCC | Hepatocellular carcinoma | 106/4020 | 168/8465 | 2.87e-05 | 1.85e-04 | 1.03e-04 | 106 |
hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa049334 | Liver | HCC | AGE-RAGE signaling pathway in diabetic complications | 62/4020 | 100/8465 | 2.35e-03 | 7.95e-03 | 4.42e-03 | 62 |
hsa05142 | Liver | HCC | Chagas disease | 61/4020 | 102/8465 | 8.04e-03 | 2.17e-02 | 1.21e-02 | 61 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0522511 | Liver | HCC | Hepatocellular carcinoma | 106/4020 | 168/8465 | 2.87e-05 | 1.85e-04 | 1.03e-04 | 106 |
hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0493311 | Liver | HCC | AGE-RAGE signaling pathway in diabetic complications | 62/4020 | 100/8465 | 2.35e-03 | 7.95e-03 | 4.42e-03 | 62 |
hsa051421 | Liver | HCC | Chagas disease | 61/4020 | 102/8465 | 8.04e-03 | 2.17e-02 | 1.21e-02 | 61 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa0421820 | Oral cavity | OSCC | Cellular senescence | 112/3704 | 156/8465 | 8.04e-13 | 1.42e-11 | 7.21e-12 | 112 |
hsa0521210 | Oral cavity | OSCC | Pancreatic cancer | 60/3704 | 76/8465 | 3.32e-10 | 4.45e-09 | 2.26e-09 | 60 |
hsa0521018 | Oral cavity | OSCC | Colorectal cancer | 66/3704 | 86/8465 | 3.99e-10 | 4.95e-09 | 2.52e-09 | 66 |
hsa0541529 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa0520526 | Oral cavity | OSCC | Proteoglycans in cancer | 128/3704 | 205/8465 | 4.00e-08 | 3.12e-07 | 1.59e-07 | 128 |
hsa0522018 | Oral cavity | OSCC | Chronic myeloid leukemia | 56/3704 | 76/8465 | 1.04e-07 | 7.43e-07 | 3.78e-07 | 56 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
TGFB2 | TGFbR1_R2 | TGFB2_TGFBR1_TGFBR2 | TGFb | Endometrium | ADJ |
TGFB2 | TGFbR1_R2 | TGFB2_TGFBR1_TGFBR2 | TGFb | Lung | AAH |
TGFB2 | TGFbR1_R2 | TGFB2_TGFBR1_TGFBR2 | TGFb | THCA | Cancer |
TGFB2 | ACVR1B_TGFbR2 | TGFB2_ACVR1B_TGFBR2 | TGFb | THCA | Cancer |
TGFB2 | ACVR1_TGFbR | TGFB2_ACVR1_TGFBR1 | TGFb | THCA | Cancer |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TGFB2 | SNV | Missense_Mutation | novel | c.613T>G | p.Leu205Val | p.L205V | P61812 | protein_coding | tolerated(0.5) | benign(0.009) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TGFB2 | SNV | Missense_Mutation | c.688G>A | p.Asp230Asn | p.D230N | P61812 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TGFB2 | insertion | Frame_Shift_Ins | novel | c.156_157insC | p.Glu55ArgfsTer5 | p.E55Rfs*5 | P61812 | protein_coding | TCGA-C5-A7CG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
TGFB2 | SNV | Missense_Mutation | c.915N>T | p.Lys305Asn | p.K305N | P61812 | protein_coding | tolerated(0.16) | benign(0.02) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD | |
TGFB2 | SNV | Missense_Mutation | c.403N>A | p.Gln135Lys | p.Q135K | P61812 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TGFB2 | SNV | Missense_Mutation | c.224G>T | p.Arg75Met | p.R75M | P61812 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TGFB2 | SNV | Missense_Mutation | rs766536496 | c.640G>A | p.Asp214Asn | p.D214N | P61812 | protein_coding | tolerated(0.29) | benign(0.021) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TGFB2 | SNV | Missense_Mutation | novel | c.1150N>G | p.Ser384Ala | p.S384A | P61812 | protein_coding | tolerated(1) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TGFB2 | SNV | Missense_Mutation | c.665N>A | p.Ala222Glu | p.A222E | P61812 | protein_coding | tolerated(0.21) | benign(0.025) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TGFB2 | SNV | Missense_Mutation | c.956T>C | p.Leu319Pro | p.L319P | P61812 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | FANG vaccine | |||
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | LERDELIMUMAB | LERDELIMUMAB | ||
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | TRABEDERSEN | TRABEDERSEN | ||
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | BELAGENPUMATUCEL-L | BELAGENPUMATUCEL-L | ||
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | antibody | FRESOLIMUMAB | FRESOLIMUMAB | |
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | AP12009 | |||
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | CHEMBL1743022 | FRESOLIMUMAB | |
7042 | TGFB2 | GROWTH FACTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | CHEMBL2108967 | LERDELIMUMAB |
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