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Gene: HNRNPD |
Gene summary for HNRNPD |
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Gene information | Species | Human | Gene symbol | HNRNPD | Gene ID | 3184 |
Gene name | heterogeneous nuclear ribonucleoprotein D | |
Gene Alias | AUF1 | |
Cytomap | 4q21.22 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q14103 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3184 | HNRNPD | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.14e-08 | -3.02e-01 | 0.0155 |
3184 | HNRNPD | HTA11_347_2000001011 | Human | Colorectum | AD | 1.61e-04 | 4.65e-01 | -0.1954 |
3184 | HNRNPD | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.92e-03 | 7.94e-01 | 0.0171 |
3184 | HNRNPD | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.24e-05 | 5.56e-01 | 0.294 |
3184 | HNRNPD | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.75e-07 | 1.11e+00 | 0.3487 |
3184 | HNRNPD | A001-C-207 | Human | Colorectum | FAP | 9.77e-03 | -4.71e-03 | 0.1278 |
3184 | HNRNPD | A015-C-203 | Human | Colorectum | FAP | 1.47e-33 | -3.58e-01 | -0.1294 |
3184 | HNRNPD | A015-C-204 | Human | Colorectum | FAP | 2.08e-07 | -3.21e-01 | -0.0228 |
3184 | HNRNPD | A014-C-040 | Human | Colorectum | FAP | 1.81e-06 | -4.96e-01 | -0.1184 |
3184 | HNRNPD | A002-C-201 | Human | Colorectum | FAP | 6.86e-17 | -3.51e-01 | 0.0324 |
3184 | HNRNPD | A002-C-203 | Human | Colorectum | FAP | 1.33e-05 | -2.20e-01 | 0.2786 |
3184 | HNRNPD | A001-C-119 | Human | Colorectum | FAP | 5.71e-05 | -2.05e-01 | -0.1557 |
3184 | HNRNPD | A001-C-108 | Human | Colorectum | FAP | 6.57e-16 | -2.46e-02 | -0.0272 |
3184 | HNRNPD | A002-C-205 | Human | Colorectum | FAP | 2.35e-22 | -1.28e-01 | -0.1236 |
3184 | HNRNPD | A001-C-104 | Human | Colorectum | FAP | 2.70e-03 | 2.69e-02 | 0.0184 |
3184 | HNRNPD | A015-C-005 | Human | Colorectum | FAP | 3.46e-02 | -8.34e-02 | -0.0336 |
3184 | HNRNPD | A015-C-006 | Human | Colorectum | FAP | 1.53e-17 | -2.17e-01 | -0.0994 |
3184 | HNRNPD | A015-C-106 | Human | Colorectum | FAP | 1.11e-19 | -3.13e-01 | -0.0511 |
3184 | HNRNPD | A002-C-114 | Human | Colorectum | FAP | 3.20e-20 | -2.67e-01 | -0.1561 |
3184 | HNRNPD | A015-C-104 | Human | Colorectum | FAP | 7.55e-35 | -1.35e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641726 | Oral cavity | EOLP | regulation of translation | 108/2218 | 468/18723 | 4.04e-12 | 7.34e-10 | 108 |
GO:004348823 | Oral cavity | EOLP | regulation of mRNA stability | 50/2218 | 158/18723 | 2.91e-11 | 4.15e-09 | 50 |
GO:004348723 | Oral cavity | EOLP | regulation of RNA stability | 51/2218 | 170/18723 | 1.63e-10 | 1.68e-08 | 51 |
GO:190331323 | Oral cavity | EOLP | positive regulation of mRNA metabolic process | 40/2218 | 118/18723 | 2.69e-10 | 2.45e-08 | 40 |
GO:003425024 | Oral cavity | EOLP | positive regulation of cellular amide metabolic process | 47/2218 | 162/18723 | 2.84e-09 | 1.77e-07 | 47 |
GO:003465523 | Oral cavity | EOLP | nucleobase-containing compound catabolic process | 89/2218 | 407/18723 | 5.47e-09 | 2.92e-07 | 89 |
GO:004572725 | Oral cavity | EOLP | positive regulation of translation | 41/2218 | 136/18723 | 8.44e-09 | 4.18e-07 | 41 |
GO:003133025 | Oral cavity | EOLP | negative regulation of cellular catabolic process | 64/2218 | 262/18723 | 9.72e-09 | 4.77e-07 | 64 |
GO:003304422 | Oral cavity | EOLP | regulation of chromosome organization | 50/2218 | 187/18723 | 1.80e-08 | 7.94e-07 | 50 |
GO:000989525 | Oral cavity | EOLP | negative regulation of catabolic process | 73/2218 | 320/18723 | 2.07e-08 | 8.84e-07 | 73 |
GO:004670023 | Oral cavity | EOLP | heterocycle catabolic process | 93/2218 | 445/18723 | 2.61e-08 | 1.08e-06 | 93 |
GO:004851117 | Oral cavity | EOLP | rhythmic process | 69/2218 | 298/18723 | 2.68e-08 | 1.11e-06 | 69 |
GO:190331225 | Oral cavity | EOLP | negative regulation of mRNA metabolic process | 31/2218 | 92/18723 | 3.14e-08 | 1.24e-06 | 31 |
GO:004427023 | Oral cavity | EOLP | cellular nitrogen compound catabolic process | 92/2218 | 451/18723 | 1.01e-07 | 3.45e-06 | 92 |
GO:006101423 | Oral cavity | EOLP | positive regulation of mRNA catabolic process | 28/2218 | 87/18723 | 4.26e-07 | 1.19e-05 | 28 |
GO:001943923 | Oral cavity | EOLP | aromatic compound catabolic process | 92/2218 | 467/18723 | 5.23e-07 | 1.40e-05 | 92 |
GO:005105222 | Oral cavity | EOLP | regulation of DNA metabolic process | 75/2218 | 359/18723 | 5.81e-07 | 1.53e-05 | 75 |
GO:000072322 | Oral cavity | EOLP | telomere maintenance | 36/2218 | 131/18723 | 8.39e-07 | 2.10e-05 | 36 |
GO:190136123 | Oral cavity | EOLP | organic cyclic compound catabolic process | 95/2218 | 495/18723 | 1.15e-06 | 2.80e-05 | 95 |
GO:190237310 | Oral cavity | EOLP | negative regulation of mRNA catabolic process | 22/2218 | 63/18723 | 1.55e-06 | 3.65e-05 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPD | SNV | Missense_Mutation | novel | c.103C>A | p.Gln35Lys | p.Q35K | Q14103 | protein_coding | tolerated_low_confidence(0.51) | benign(0) | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
HNRNPD | SNV | Missense_Mutation | c.995N>G | p.Tyr332Cys | p.Y332C | Q14103 | protein_coding | tolerated(0.05) | probably_damaging(0.926) | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
HNRNPD | SNV | Missense_Mutation | novel | c.766G>T | p.Val256Leu | p.V256L | Q14103 | protein_coding | tolerated(0.06) | benign(0.05) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HNRNPD | SNV | Missense_Mutation | novel | c.757N>A | p.Glu253Lys | p.E253K | Q14103 | protein_coding | deleterious(0.04) | possibly_damaging(0.842) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
HNRNPD | insertion | Frame_Shift_Ins | novel | c.793_794insT | p.Gln265LeufsTer8 | p.Q265Lfs*8 | Q14103 | protein_coding | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | ||
HNRNPD | SNV | Missense_Mutation | c.1052G>A | p.Ser351Asn | p.S351N | Q14103 | protein_coding | tolerated(1) | possibly_damaging(0.878) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPD | SNV | Missense_Mutation | novel | c.565N>A | p.Leu189Ile | p.L189I | Q14103 | protein_coding | deleterious(0.01) | possibly_damaging(0.759) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HNRNPD | SNV | Missense_Mutation | c.528N>C | p.Lys176Asn | p.K176N | Q14103 | protein_coding | deleterious(0.02) | possibly_damaging(0.824) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPD | SNV | Missense_Mutation | c.526A>C | p.Lys176Gln | p.K176Q | Q14103 | protein_coding | tolerated(0.05) | benign(0.254) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
HNRNPD | SNV | Missense_Mutation | c.464N>C | p.Met155Thr | p.M155T | Q14103 | protein_coding | deleterious(0.01) | benign(0.138) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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