Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DNM1

Gene summary for DNM1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DNM1

Gene ID

1759

Gene namedynamin 1
Gene AliasDEE31
Cytomap9q34.11
Gene Typeprotein-coding
GO ID

GO:0002029

UniProtAcc

Q05193


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1759DNM1HCC1_MengHumanLiverHCC1.94e-03-3.73e-030.0246
1759DNM1HCC1HumanLiverHCC2.52e-021.43e+000.5336
1759DNM1S014HumanLiverHCC5.82e-331.01e+000.2254
1759DNM1S015HumanLiverHCC5.65e-288.58e-010.2375
1759DNM1S016HumanLiverHCC2.09e-371.01e+000.2243
1759DNM1S027HumanLiverHCC4.78e-095.42e-010.2446
1759DNM1S028HumanLiverHCC3.43e-185.17e-010.2503
1759DNM1S029HumanLiverHCC7.71e-114.00e-010.2581
1759DNM1ATC09HumanThyroidATC1.12e-052.16e-010.2871
1759DNM1ATC12HumanThyroidATC5.13e-224.26e-010.34
1759DNM1ATC13HumanThyroidATC1.51e-531.06e+000.34
1759DNM1ATC1HumanThyroidATC8.73e-062.51e-010.2878
1759DNM1ATC4HumanThyroidATC3.45e-275.05e-010.34
1759DNM1ATC5HumanThyroidATC1.60e-621.12e+000.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000183625ThyroidPTCrelease of cytochrome c from mitochondria32/596859/187233.06e-042.14e-0332
GO:00507752ThyroidPTCpositive regulation of dendrite morphogenesis22/596837/187234.92e-043.23e-0322
GO:003210316ThyroidPTCpositive regulation of response to external stimulus167/5968427/187238.31e-045.13e-03167
GO:00482855ThyroidPTCorganelle fission188/5968488/187239.64e-045.77e-03188
GO:00902006ThyroidPTCpositive regulation of release of cytochrome c from mitochondria17/596828/187231.55e-038.63e-0317
GO:005092115ThyroidPTCpositive regulation of chemotaxis62/5968141/187231.67e-039.16e-0362
GO:00995325ThyroidPTCsynaptic vesicle endosomal processing8/596810/187232.46e-031.27e-028
GO:009019910ThyroidPTCregulation of release of cytochrome c from mitochondria25/596848/187232.86e-031.42e-0225
GO:001082318ThyroidPTCnegative regulation of mitochondrion organization25/596849/187234.09e-031.95e-0225
GO:007058410ThyroidPTCmitochondrion morphogenesis13/596821/187234.41e-032.08e-0213
GO:00488144ThyroidPTCregulation of dendrite morphogenesis32/596867/187234.75e-032.22e-0232
GO:00508089ThyroidPTCsynapse organization161/5968426/187235.11e-032.36e-02161
GO:000269015ThyroidPTCpositive regulation of leukocyte chemotaxis42/596894/187236.16e-032.74e-0242
GO:000268718ThyroidPTCpositive regulation of leukocyte migration57/5968135/187237.15e-033.07e-0257
GO:00507735ThyroidPTCregulation of dendrite development45/5968103/187237.70e-033.27e-0245
GO:00508074ThyroidPTCregulation of synapse organization84/5968211/187238.72e-033.64e-0284
GO:007169216ThyroidPTCprotein localization to extracellular region139/5968368/187238.95e-033.72e-02139
GO:00080534ThyroidPTCmitochondrial fusion15/596827/187239.19e-033.79e-0215
GO:00702656ThyroidPTCnecrotic cell death29/596862/187239.96e-034.07e-0229
GO:00901402ThyroidPTCregulation of mitochondrial fission17/596832/187231.02e-024.11e-0217
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0414422LiverHCCEndocytosis178/4020251/84652.03e-145.22e-132.91e-13178
hsa0510022LiverHCCBacterial invasion of epithelial cells51/402077/84656.67e-042.72e-031.52e-0351
hsa0414432LiverHCCEndocytosis178/4020251/84652.03e-145.22e-132.91e-13178
hsa0510032LiverHCCBacterial invasion of epithelial cells51/402077/84656.67e-042.72e-031.52e-0351
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DNM1SNVMissense_Mutationnovelc.370G>Tp.Val124Phep.V124FQ05193protein_codingdeleterious(0)probably_damaging(1)TCGA-A2-A04T-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
DNM1SNVMissense_Mutationrs755327329c.1319N>Ap.Arg440Lysp.R440KQ05193protein_codingtolerated(0.19)benign(0.09)TCGA-A2-A0CX-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
DNM1SNVMissense_Mutationnovelc.536C>Tp.Ser179Phep.S179FQ05193protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AC-A5XS-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
DNM1SNVMissense_Mutationc.767G>Tp.Arg256Leup.R256LQ05193protein_codingdeleterious(0.01)probably_damaging(0.992)TCGA-AO-A0J9-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamidePD
DNM1SNVMissense_Mutationc.1978G>Cp.Glu660Glnp.E660QQ05193protein_codingdeleterious(0.02)probably_damaging(0.988)TCGA-B6-A1KF-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
DNM1SNVMissense_Mutationrs773857861c.1394N>Ap.Arg465Glnp.R465QQ05193protein_codingdeleterious(0.03)possibly_damaging(0.788)TCGA-C8-A1HG-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
DNM1SNVMissense_Mutationnovelc.623N>Gp.Asp208Glyp.D208GQ05193protein_codingdeleterious(0)probably_damaging(0.988)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
DNM1SNVMissense_Mutationc.1564N>Tp.Arg522Cysp.R522CQ05193protein_codingdeleterious(0.05)probably_damaging(0.954)TCGA-E2-A1LA-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
DNM1SNVMissense_Mutationc.2001N>Ap.Asp667Glup.D667EQ05193protein_codingtolerated(0.1)probably_damaging(0.989)TCGA-E2-A1LS-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificCyclophosphamideSD
DNM1SNVMissense_Mutationnovelc.634G>Ap.Glu212Lysp.E212KQ05193protein_codingdeleterious(0.04)probably_damaging(0.97)TCGA-E9-A2JT-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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